Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NHLH2 (nescient helix-loop-helix 2)

Identity

Alias (NCBI)HEN2
NSCL2
bHLHa34
HGNC (Hugo) NHLH2
HGNC Alias symbNSCL2
bHLHa34
HGNC Previous nameHEN2
HGNC Previous namenescient helix loop helix 2
LocusID (NCBI) 4808
Atlas_Id 41537
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 115836378 and ends at 115841126 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)NHLH2   7818
Cards
Entrez_Gene (NCBI)NHLH2    nescient helix-loop-helix 2
AliasesHEN2; NSCL2; bHLHa34
GeneCards (Weizmann)NHLH2
Ensembl hg19 (Hinxton)ENSG00000177551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177551 [Gene_View]  ENSG00000177551 [Sequence]  chr1:115836378-115841126 [Contig_View]  NHLH2 [Vega]
ICGC DataPortalENSG00000177551
TCGA cBioPortalNHLH2
AceView (NCBI)NHLH2
Genatlas (Paris)NHLH2
SOURCE (Princeton)NHLH2
Genetics Home Reference (NIH)NHLH2
Genomic and cartography
GoldenPath hg38 (UCSC)NHLH2  -     chr1:115836378-115841126 -  1p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NHLH2  -     1p13.1   [Description]    (hg19-Feb_2009)
GoldenPathNHLH2 - 1p13.1 [CytoView hg19]  NHLH2 - 1p13.1 [CytoView hg38]
ImmunoBaseENSG00000177551
genome Data Viewer NCBINHLH2 [Mapview hg19]  
OMIM162361   
Gene and transcription
Genbank (Entrez)AA166895 AB007959 AK056621 AK307156 AK312849
RefSeq transcript (Entrez)NM_001111061 NM_005599
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NHLH2
Alternative Splicing GalleryENSG00000177551
Gene ExpressionNHLH2 [ NCBI-GEO ]   NHLH2 [ EBI - ARRAY_EXPRESS ]   NHLH2 [ SEEK ]   NHLH2 [ MEM ]
Gene Expression Viewer (FireBrowse)NHLH2 [ Firebrowse - Broad ]
GenevisibleExpression of NHLH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4808
GTEX Portal (Tissue expression)NHLH2
Human Protein AtlasENSG00000177551-NHLH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02577   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02577  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02577
Splice isoforms : SwissVarQ02577
PhosPhoSitePlusQ02577
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    HLH_DNA-bd_sf    TAL-like   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)NHLH2
Blocks (Seattle)NHLH2
SuperfamilyQ02577
Human Protein Atlas [tissue]ENSG00000177551-NHLH2 [tissue]
Peptide AtlasQ02577
HPRD01213
IPIIPI00026246   IPI00742729   IPI00853619   
Protein Interaction databases
DIP (DOE-UCLA)Q02577
IntAct (EBI)Q02577
BioGRIDNHLH2
STRING (EMBL)NHLH2
ZODIACNHLH2
Ontologies - Pathways
QuickGOQ02577
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  apoptotic process  central nervous system development  male gonad development  cell migration in hindbrain  cell differentiation  ovulation cycle  positive regulation of transcription by RNA polymerase II  protein dimerization activity  positive regulation of DNA-binding transcription factor activity  male mating behavior  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  apoptotic process  central nervous system development  male gonad development  cell migration in hindbrain  cell differentiation  ovulation cycle  positive regulation of transcription by RNA polymerase II  protein dimerization activity  positive regulation of DNA-binding transcription factor activity  male mating behavior  sequence-specific double-stranded DNA binding  
NDEx NetworkNHLH2
Atlas of Cancer Signalling NetworkNHLH2
Wikipedia pathwaysNHLH2
Orthology - Evolution
OrthoDB4808
GeneTree (enSembl)ENSG00000177551
Phylogenetic Trees/Animal Genes : TreeFamNHLH2
HOGENOMQ02577
Homologs : HomoloGeneNHLH2
Homology/Alignments : Family Browser (UCSC)NHLH2
Gene fusions - Rearrangements
Fusion : QuiverNHLH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNHLH2 [hg38]
dbVarNHLH2
ClinVarNHLH2
MonarchNHLH2
1000_GenomesNHLH2 
Exome Variant ServerNHLH2
GNOMAD BrowserENSG00000177551
Varsome BrowserNHLH2
Genomic Variants (DGV)NHLH2 [DGVbeta]
DECIPHERNHLH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNHLH2 
Mutations
ICGC Data PortalNHLH2 
TCGA Data PortalNHLH2 
Broad Tumor PortalNHLH2
OASIS PortalNHLH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNHLH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNHLH2
Mutations and Diseases : HGMDNHLH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NHLH2
DgiDB (Drug Gene Interaction Database)NHLH2
DoCM (Curated mutations)NHLH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NHLH2 (select a term)
intoGenNHLH2
Cancer3DNHLH2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162361   
Orphanet
DisGeNETNHLH2
MedgenNHLH2
Genetic Testing Registry NHLH2
NextProtQ02577 [Medical]
GENETestsNHLH2
Target ValidationNHLH2
Huge Navigator NHLH2 [HugePedia]
ClinGenNHLH2
Clinical trials, drugs, therapy
MyCancerGenomeNHLH2
Protein Interactions : CTD
Pharm GKB GenePA31620
PharosQ02577
Clinical trialNHLH2
Miscellaneous
canSAR (ICR)NHLH2 (select the gene name)
HarmonizomeNHLH2
DataMed IndexNHLH2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNHLH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:36:30 CET 2021

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