Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NHLH2 (nescient helix-loop-helix 2)

Identity

Alias_namesHEN2
nescient helix loop helix 2
Alias_symbol (synonym)NSCL2
bHLHa34
Other alias
HGNC (Hugo) NHLH2
LocusID (NCBI) 4808
Atlas_Id 41537
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 115836378 and ends at 115840712 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NHLH2   7818
Cards
Entrez_Gene (NCBI)NHLH2  4808  nescient helix-loop-helix 2
AliasesHEN2; NSCL2; bHLHa34
GeneCards (Weizmann)NHLH2
Ensembl hg19 (Hinxton)ENSG00000177551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177551 [Gene_View]  chr1:115836378-115840712 [Contig_View]  NHLH2 [Vega]
ICGC DataPortalENSG00000177551
TCGA cBioPortalNHLH2
AceView (NCBI)NHLH2
Genatlas (Paris)NHLH2
WikiGenes4808
SOURCE (Princeton)NHLH2
Genetics Home Reference (NIH)NHLH2
Genomic and cartography
GoldenPath hg38 (UCSC)NHLH2  -     chr1:115836378-115840712 -  1p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NHLH2  -     1p13.1   [Description]    (hg19-Feb_2009)
EnsemblNHLH2 - 1p13.1 [CytoView hg19]  NHLH2 - 1p13.1 [CytoView hg38]
Mapping of homologs : NCBINHLH2 [Mapview hg19]  NHLH2 [Mapview hg38]
OMIM162361   
Gene and transcription
Genbank (Entrez)AA166895 AB007959 AK056621 AK307156 AK312849
RefSeq transcript (Entrez)NM_001111061 NM_005599
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NHLH2
Cluster EST : UnigeneHs.46296 [ NCBI ]
CGAP (NCI)Hs.46296
Alternative Splicing GalleryENSG00000177551
Gene ExpressionNHLH2 [ NCBI-GEO ]   NHLH2 [ EBI - ARRAY_EXPRESS ]   NHLH2 [ SEEK ]   NHLH2 [ MEM ]
Gene Expression Viewer (FireBrowse)NHLH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4808
GTEX Portal (Tissue expression)NHLH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02577   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02577  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02577
Splice isoforms : SwissVarQ02577
PhosPhoSitePlusQ02577
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)NHLH2
DMDM Disease mutations4808
Blocks (Seattle)NHLH2
SuperfamilyQ02577
Human Protein AtlasENSG00000177551
Peptide AtlasQ02577
HPRD01213
IPIIPI00026246   IPI00742729   IPI00853619   
Protein Interaction databases
DIP (DOE-UCLA)Q02577
IntAct (EBI)Q02577
FunCoupENSG00000177551
BioGRIDNHLH2
STRING (EMBL)NHLH2
ZODIACNHLH2
Ontologies - Pathways
QuickGOQ02577
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  central nervous system development  mating behavior  cell differentiation  ovulation cycle  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  central nervous system development  mating behavior  cell differentiation  ovulation cycle  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  
NDEx NetworkNHLH2
Atlas of Cancer Signalling NetworkNHLH2
Wikipedia pathwaysNHLH2
Orthology - Evolution
OrthoDB4808
GeneTree (enSembl)ENSG00000177551
Phylogenetic Trees/Animal Genes : TreeFamNHLH2
HOVERGENQ02577
HOGENOMQ02577
Homologs : HomoloGeneNHLH2
Homology/Alignments : Family Browser (UCSC)NHLH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNHLH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NHLH2
dbVarNHLH2
ClinVarNHLH2
1000_GenomesNHLH2 
Exome Variant ServerNHLH2
ExAC (Exome Aggregation Consortium)NHLH2 (select the gene name)
Genetic variants : HAPMAP4808
Genomic Variants (DGV)NHLH2 [DGVbeta]
DECIPHERNHLH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNHLH2 
Mutations
ICGC Data PortalNHLH2 
TCGA Data PortalNHLH2 
Broad Tumor PortalNHLH2
OASIS PortalNHLH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNHLH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNHLH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NHLH2
DgiDB (Drug Gene Interaction Database)NHLH2
DoCM (Curated mutations)NHLH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NHLH2 (select a term)
intoGenNHLH2
Cancer3DNHLH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162361   
Orphanet
MedgenNHLH2
Genetic Testing Registry NHLH2
NextProtQ02577 [Medical]
TSGene4808
GENETestsNHLH2
Target ValidationNHLH2
Huge Navigator NHLH2 [HugePedia]
snp3D : Map Gene to Disease4808
BioCentury BCIQNHLH2
ClinGenNHLH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4808
Chemical/Pharm GKB GenePA31620
Clinical trialNHLH2
Miscellaneous
canSAR (ICR)NHLH2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNHLH2
EVEXNHLH2
GoPubMedNHLH2
iHOPNHLH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:22:08 CEST 2017

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