NHLH2 (nescient helix-loop-helix 2)

2003-02-01  

Identity

HGNC
LOCATION
1p13.1
LOCUSID
ALIAS
HEN2,NSCL2,bHLHa34

Other Information

Locus ID:

NCBI: 4808
MIM: 162361
HGNC: 7818
Ensembl: ENSG00000177551

Variants:

dbSNP: 4808
ClinVar: 4808
TCGA: ENSG00000177551
COSMIC: NHLH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177551ENST00000320238Q02577
ENSG00000177551ENST00000320238A0A024R0I7
ENSG00000177551ENST00000369506Q02577
ENSG00000177551ENST00000369506A0A024R0I7
ENSG00000177551ENST00000429731A6PVY9

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
159302762005LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.43
215732142011Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.23
188154872008Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.14
244861922014Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).5
261968642015A Genetic Basis for Motivated Exercise.5
230262122013Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.2

Citation

Dessen P

NHLH2 (nescient helix-loop-helix 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41537/nhlh2