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NHP2 (NHP2 ribonucleoprotein)

Identity

Other namesDKCB2
NHP2P
NOLA2
HGNC (Hugo) NHP2
LocusID (NCBI) 55651
Atlas_Id 50417
Location 5q35.3
Location_base_pair Starts at 177576465 and ends at 177580961 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NHP2 (5q35.3) / UBXN6 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Dyskeratosis congenita (DKC)

External links

Nomenclature
HGNC (Hugo)NHP2   14377
Cards
Entrez_Gene (NCBI)NHP2  55651  NHP2 ribonucleoprotein
GeneCards (Weizmann)NHP2
Ensembl hg19 (Hinxton)ENSG00000145912 [Gene_View]  chr5:177576465-177580961 [Contig_View]  NHP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145912 [Gene_View]  chr5:177576465-177580961 [Contig_View]  NHP2 [Vega]
ICGC DataPortalENSG00000145912
TCGA cBioPortalNHP2
AceView (NCBI)NHP2
Genatlas (Paris)NHP2
WikiGenes55651
SOURCE (Princeton)NHP2
Genomic and cartography
GoldenPath hg19 (UCSC)NHP2  -     chr5:177576465-177580961 -  5q35.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NHP2  -     5q35.3   [Description]    (hg38-Dec_2013)
EnsemblNHP2 - 5q35.3 [CytoView hg19]  NHP2 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBINHP2 [Mapview hg19]  NHP2 [Mapview hg38]
OMIM224230   606470   613987   
Gene and transcription
Genbank (Entrez)AF161404 AF401217 AF401219 AJ293309 AK000486
RefSeq transcript (Entrez)NM_001034833 NM_017838
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_011765 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)NHP2
Cluster EST : UnigeneHs.744074 [ NCBI ]
CGAP (NCI)Hs.744074
Alternative Splicing GalleryENSG00000145912
Gene ExpressionNHP2 [ NCBI-GEO ]   NHP2 [ EBI - ARRAY_EXPRESS ]   NHP2 [ SEEK ]   NHP2 [ MEM ]
Gene Expression Viewer (FireBrowse)NHP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55651
GTEX Portal (Tissue expression)NHP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NX24 (Uniprot)
NextProtQ9NX24  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NX24
Splice isoforms : SwissVarQ9NX24 (Swissvar)
PhosPhoSitePlusQ9NX24
Domains : Interpro (EBI)H/ACA_rnp_Nhp2_euk    L30e-like    Ribosomal_L7Ae/L30e/S12e/Gad45    Ribosomal_L7Ae/L8/Nhp2   
Domain families : Pfam (Sanger)Ribosomal_L7Ae (PF01248)   
Domain families : Pfam (NCBI)pfam01248   
DMDM Disease mutations55651
Blocks (Seattle)NHP2
SuperfamilyQ9NX24
Human Protein AtlasENSG00000145912
Peptide AtlasQ9NX24
HPRD07570
IPIIPI00041325   IPI00654617   IPI00968276   IPI00966700   IPI00983095   
Protein Interaction databases
DIP (DOE-UCLA)Q9NX24
IntAct (EBI)Q9NX24
FunCoupENSG00000145912
BioGRIDNHP2
STRING (EMBL)NHP2
ZODIACNHP2
Ontologies - Pathways
QuickGOQ9NX24
Ontology : AmiGOnuclear chromosome, telomeric region  protein binding  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  telomerase holoenzyme complex  small nucleolar ribonucleoprotein complex  cytoplasm  telomere maintenance via telomerase  snoRNA binding  rRNA pseudouridine synthesis  rRNA pseudouridine synthesis  box H/ACA snoRNP complex  box H/ACA snoRNP complex  box H/ACA snoRNA binding  poly(A) RNA binding  telomerase RNA binding  box H/ACA scaRNP complex  box H/ACA telomerase RNP complex  box H/ACA telomerase RNP complex  positive regulation of telomerase RNA localization to Cajal body  
Ontology : EGO-EBInuclear chromosome, telomeric region  protein binding  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  telomerase holoenzyme complex  small nucleolar ribonucleoprotein complex  cytoplasm  telomere maintenance via telomerase  snoRNA binding  rRNA pseudouridine synthesis  rRNA pseudouridine synthesis  box H/ACA snoRNP complex  box H/ACA snoRNP complex  box H/ACA snoRNA binding  poly(A) RNA binding  telomerase RNA binding  box H/ACA scaRNP complex  box H/ACA telomerase RNP complex  box H/ACA telomerase RNP complex  positive regulation of telomerase RNA localization to Cajal body  
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx Network
Atlas of Cancer Signalling NetworkNHP2
Wikipedia pathwaysNHP2
Orthology - Evolution
OrthoDB55651
GeneTree (enSembl)ENSG00000145912
Phylogenetic Trees/Animal Genes : TreeFamNHP2
Homologs : HomoloGeneNHP2
Homology/Alignments : Family Browser (UCSC)NHP2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerNHP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NHP2
dbVarNHP2
ClinVarNHP2
1000_GenomesNHP2 
Exome Variant ServerNHP2
ExAC (Exome Aggregation Consortium)NHP2 (select the gene name)
Genetic variants : HAPMAP55651
Genomic Variants (DGV)NHP2 [DGVbeta]
Mutations
ICGC Data PortalNHP2 
TCGA Data PortalNHP2 
Broad Tumor PortalNHP2
OASIS PortalNHP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNHP2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch NHP2
DgiDB (Drug Gene Interaction Database)NHP2
DoCM (Curated mutations)NHP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NHP2 (select a term)
intoGenNHP2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:177576465-177580961  ENSG00000145912
CONAN: Copy Number AnalysisNHP2 
Mutations and Diseases : HGMDNHP2
OMIM224230    606470    613987   
MedgenNHP2
Genetic Testing Registry NHP2
NextProtQ9NX24 [Medical]
TSGene55651
GENETestsNHP2
Huge Navigator NHP2 [HugePedia]
snp3D : Map Gene to Disease55651
BioCentury BCIQNHP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55651
Chemical/Pharm GKB GenePA164723898
Clinical trialNHP2
Miscellaneous
canSAR (ICR)NHP2 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNHP2
EVEXNHP2
GoPubMedNHP2
iHOPNHP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:58:03 CEST 2016

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