NIFK (nucleolar protein interacting with the FHA domain of MKI67)

2017-01-01  

Identity

HGNC
NIFK
LOCATION
2q14.3
LOCUSID
84365
ALIAS
MKI67IP,Nopp34
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84365
MIM: 611970
HGNC: 17838
Ensembl: ENSG00000155438

Variants:

dbSNP: 84365
ClinVar: 84365
TCGA: ENSG00000155438
COSMIC: NIFK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155438ENST00000285814Q9BYG3
ENSG00000155438ENST00000423105H7BZL0
ENSG00000155438ENST00000447132C9J808
ENSG00000155438ENST00000451734C9J6C5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146597642004Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.13
269842802016The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.12
258266592015The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.8
178910462007Human nasal turbinates as a viable source of respiratory epithelial cells using co-culture system versus dispase-dissociation technique.3
215397732011Direct observations of shifts in the β-sheet register of a protein-peptide complex using explicit solvent simulations.3

Citation

Dessen P

NIFK (nucleolar protein interacting with the FHA domain of MKI67)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56695/nifk