NINL (ninein like)

2009-05-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
NLP
FUSION GENES

Other Information

Locus ID:

NCBI: 22981
MIM: 609580
HGNC: 29163
Ensembl: ENSG00000101004

Variants:

dbSNP: 22981
ClinVar: 22981
TCGA: ENSG00000101004
COSMIC: NINL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101004ENST00000278886Q9Y2I6
ENSG00000101004ENST00000336104H0Y2V7
ENSG00000101004ENST00000422516Q9Y2I6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162542472005Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.34
264856452015The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.26
188269612009Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein.18
200937782010Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice.16
174036702007Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.13
185388322008Increased expression of Nlp, a potential oncogene in ovarian cancer, and its implication in carcinogenesis.9
195093002009BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression.9
197248572009Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to cancer growth and resistance to apoptosis.8
208645402010Aurora B interaction of centrosomal Nlp regulates cytokinesis.5
215054542011The role of centrosomal Nlp in the control of mitotic progression and tumourigenesis.5

Citation

Dessen P

NINL (ninein like)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50859/ninl