NISCH (nischarin)

2011-12-01  

Identity

HGNC
NISCH
LOCATION
3p21.1
LOCUSID
11188
ALIAS
I-1,IR1,IRAS,hIRAS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11188
MIM: 615507
HGNC: 18006
Ensembl: ENSG00000010322

Variants:

dbSNP: 11188
ClinVar: 11188
TCGA: ENSG00000010322
COSMIC: NISCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010322ENST00000345716Q9Y2I1
ENSG00000010322ENST00000420808Q9Y2I1
ENSG00000010322ENST00000479054Q9Y2I1
ENSG00000010322ENST00000488380C9J715

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
209356292010Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.396
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
219176052011Molecular characterization of the tumor-suppressive function of nischarin in breast cancer.20
119121942002Insulin receptor substrate 4 associates with the protein IRAS.11
154753482004Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
235725242013Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.10
165987782006Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein.6
294157252018Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells.5
120215822002Imidazoline receptors in the heart: characterization, distribution, and regulation.4

Citation

Dessen P

NISCH (nischarin)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52509/nisch