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NIT2 (nitrilase family member 2)

Identity

Alias_namesnitrilase family
Other aliasHEL-S-8a
HGNC (Hugo) NIT2
LocusID (NCBI) 56954
Atlas_Id 41538
Location 3q12.2  [Link to chromosome band 3q12]
Location_base_pair Starts at 100053562 and ends at 100074478 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAP1GAP (1p36.12) / NIT2 (3q12.2)RAP1GAP 1p36.12 / NIT2 3q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NIT2   29878
Cards
Entrez_Gene (NCBI)NIT2  56954  nitrilase family member 2
AliasesHEL-S-8a
GeneCards (Weizmann)NIT2
Ensembl hg19 (Hinxton)ENSG00000114021 [Gene_View]  chr3:100053562-100074478 [Contig_View]  NIT2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114021 [Gene_View]  chr3:100053562-100074478 [Contig_View]  NIT2 [Vega]
ICGC DataPortalENSG00000114021
TCGA cBioPortalNIT2
AceView (NCBI)NIT2
Genatlas (Paris)NIT2
WikiGenes56954
SOURCE (Princeton)NIT2
Genetics Home Reference (NIH)NIT2
Genomic and cartography
GoldenPath hg19 (UCSC)NIT2  -     chr3:100053562-100074478 +  3q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NIT2  -     3q12.2   [Description]    (hg38-Dec_2013)
EnsemblNIT2 - 3q12.2 [CytoView hg19]  NIT2 - 3q12.2 [CytoView hg38]
Mapping of homologs : NCBINIT2 [Mapview hg19]  NIT2 [Mapview hg38]
OMIM616769   
Gene and transcription
Genbank (Entrez)AF260334 AF284574 AK225979 AK294010 AK295835
RefSeq transcript (Entrez)NM_020202
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)NIT2
Cluster EST : UnigeneHs.439152 [ NCBI ]
CGAP (NCI)Hs.439152
Alternative Splicing GalleryENSG00000114021
Gene ExpressionNIT2 [ NCBI-GEO ]   NIT2 [ EBI - ARRAY_EXPRESS ]   NIT2 [ SEEK ]   NIT2 [ MEM ]
Gene Expression Viewer (FireBrowse)NIT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56954
GTEX Portal (Tissue expression)NIT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQR4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQR4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQR4
Splice isoforms : SwissVarQ9NQR4
Catalytic activity : Enzyme3.5.1.3 [ Enzyme-Expasy ]   3.5.1.33.5.1.3 [ IntEnz-EBI ]   3.5.1.3 [ BRENDA ]   3.5.1.3 [ KEGG ]   
PhosPhoSitePlusQ9NQR4
Domaine pattern : Prosite (Expaxy)CN_HYDROLASE (PS50263)   
Domains : Interpro (EBI)C-N_Hydrolase   
Domain families : Pfam (Sanger)CN_hydrolase (PF00795)   
Domain families : Pfam (NCBI)pfam00795   
Conserved Domain (NCBI)NIT2
DMDM Disease mutations56954
Blocks (Seattle)NIT2
SuperfamilyQ9NQR4
Human Protein AtlasENSG00000114021
Peptide AtlasQ9NQR4
HPRD17634
IPIIPI00549467   IPI00945908   IPI00945724   IPI00790618   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQR4
IntAct (EBI)Q9NQR4
FunCoupENSG00000114021
BioGRIDNIT2
STRING (EMBL)NIT2
ZODIACNIT2
Ontologies - Pathways
QuickGOQ9NQR4
Ontology : AmiGOcytoplasm  mitochondrion  centrosome  oxaloacetate metabolic process  asparagine metabolic process  glutamine metabolic process  omega-amidase activity  extracellular exosome  
Ontology : EGO-EBIcytoplasm  mitochondrion  centrosome  oxaloacetate metabolic process  asparagine metabolic process  glutamine metabolic process  omega-amidase activity  extracellular exosome  
Pathways : KEGGAlanine, aspartate and glutamate metabolism   
NDEx NetworkNIT2
Atlas of Cancer Signalling NetworkNIT2
Wikipedia pathwaysNIT2
Orthology - Evolution
OrthoDB56954
GeneTree (enSembl)ENSG00000114021
Phylogenetic Trees/Animal Genes : TreeFamNIT2
HOVERGENQ9NQR4
HOGENOMQ9NQR4
Homologs : HomoloGeneNIT2
Homology/Alignments : Family Browser (UCSC)NIT2
Gene fusions - Rearrangements
Fusion : MitelmanRAP1GAP/NIT2 [1p36.12/3q12.2]  [t(1;3)(p36;q12)]  
Fusion: TCGARAP1GAP 1p36.12 NIT2 3q12.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNIT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NIT2
dbVarNIT2
ClinVarNIT2
1000_GenomesNIT2 
Exome Variant ServerNIT2
ExAC (Exome Aggregation Consortium)NIT2 (select the gene name)
Genetic variants : HAPMAP56954
Genomic Variants (DGV)NIT2 [DGVbeta]
DECIPHER (Syndromes)3:100053562-100074478  ENSG00000114021
CONAN: Copy Number AnalysisNIT2 
Mutations
ICGC Data PortalNIT2 
TCGA Data PortalNIT2 
Broad Tumor PortalNIT2
OASIS PortalNIT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNIT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNIT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NIT2
DgiDB (Drug Gene Interaction Database)NIT2
DoCM (Curated mutations)NIT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NIT2 (select a term)
intoGenNIT2
Cancer3DNIT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616769   
Orphanet
MedgenNIT2
Genetic Testing Registry NIT2
NextProtQ9NQR4 [Medical]
TSGene56954
GENETestsNIT2
Huge Navigator NIT2 [HugePedia]
snp3D : Map Gene to Disease56954
BioCentury BCIQNIT2
ClinGenNIT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56954
Chemical/Pharm GKB GenePA134882857
Clinical trialNIT2
Miscellaneous
canSAR (ICR)NIT2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNIT2
EVEXNIT2
GoPubMedNIT2
iHOPNIT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:17 CEST 2017

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