Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NKAIN2 (sodium/potassium transporting ATPase interacting 2)

Identity

Alias (NCBI)FAM77B
NKAIP2
TCBA
TCBA1
HGNC (Hugo) NKAIN2
HGNC Alias symbFAM77B
HGNC Previous nameTCBA1
HGNC Previous nameT-cell lymphoma breakpoint associated target 1
 Na+/K+ transporting ATPase interacting 2
LocusID (NCBI) 154215
Atlas_Id 42488
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 123803846 and ends at 124825640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / NKAIN2 (6q22.31)MAP3K5 (6q23.3) / NKAIN2 (6q22.31)MTHFD1L (6q25.1) / NKAIN2 (6q22.31)
NCOA7 (6q22.32) / NKAIN2 (6q22.31)NKAIN2 (6q22.31) / ETV6 (12p13.2)NKAIN2 (6q22.31) / MS4A12 (11q12.2)
NKAIN2 (6q22.31) / MYOT (5q31.2)NKAIN2 (6q22.31) / NEK1 (4q33)NKAIN2 (6q22.31) / RNF217 (6q22.31)
NKAIN2 (6q22.31) / SENP6 (6q14.1)SENP6 (6q14.1) / NKAIN2 (6q22.31)SNX14 (6q14.3) / NKAIN2 (6q22.31)
SRSF5 (14q24.2) / NKAIN2 (6q22.31)MAP3K5 6q23.3 / NKAIN2 6q22.31NKAIN2 6q22.31 / MS4A12 11q12.2
SNX14 6q14.3 / NKAIN2 6q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q21) SENP6/NKAIN2


External links

 

Nomenclature
HGNC (Hugo)NKAIN2   16443
Cards
Entrez_Gene (NCBI)NKAIN2    sodium/potassium transporting ATPase interacting 2
AliasesFAM77B; NKAIP2; TCBA; TCBA1
GeneCards (Weizmann)NKAIN2
Ensembl hg19 (Hinxton)ENSG00000188580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188580 [Gene_View]  ENSG00000188580 [Sequence]  chr6:123803846-124825640 [Contig_View]  NKAIN2 [Vega]
ICGC DataPortalENSG00000188580
TCGA cBioPortalNKAIN2
AceView (NCBI)NKAIN2
Genatlas (Paris)NKAIN2
SOURCE (Princeton)NKAIN2
Genetics Home Reference (NIH)NKAIN2
Genomic and cartography
GoldenPath hg38 (UCSC)NKAIN2  -     chr6:123803846-124825640 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKAIN2  -     6q22.31   [Description]    (hg19-Feb_2009)
GoldenPathNKAIN2 - 6q22.31 [CytoView hg19]  NKAIN2 - 6q22.31 [CytoView hg38]
ImmunoBaseENSG00000188580
Genome Data Viewer NCBINKAIN2 [Mapview hg19]  
OMIM609758   
Gene and transcription
Genbank (Entrez)AB070452 AK055326 AK308927 AK309385 AK309407
RefSeq transcript (Entrez)NM_001040214 NM_001300737 NM_001300738 NM_001300740 NM_153355
Consensus coding sequences : CCDS (NCBI)NKAIN2
Gene ExpressionNKAIN2 [ NCBI-GEO ]   NKAIN2 [ EBI - ARRAY_EXPRESS ]   NKAIN2 [ SEEK ]   NKAIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKAIN2 [ Firebrowse - Broad ]
GenevisibleExpression of NKAIN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154215
GTEX Portal (Tissue expression)NKAIN2
Human Protein AtlasENSG00000188580-NKAIN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VXU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VXU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VXU1
PhosPhoSitePlusQ5VXU1
Domains : Interpro (EBI)Na/K-Atpase_Interacting   
Domain families : Pfam (Sanger)NKAIN (PF05640)   
Domain families : Pfam (NCBI)pfam05640   
Conserved Domain (NCBI)NKAIN2
SuperfamilyQ5VXU1
AlphaFold pdb e-kbQ5VXU1   
Human Protein Atlas [tissue]ENSG00000188580-NKAIN2 [tissue]
HPRD18168
Protein Interaction databases
DIP (DOE-UCLA)Q5VXU1
IntAct (EBI)Q5VXU1
BioGRIDNKAIN2
STRING (EMBL)NKAIN2
ZODIACNKAIN2
Ontologies - Pathways
QuickGOQ5VXU1
Ontology : AmiGOregulation of sodium ion transport  plasma membrane  integral component of membrane  
Ontology : EGO-EBIregulation of sodium ion transport  plasma membrane  integral component of membrane  
NDEx NetworkNKAIN2
Atlas of Cancer Signalling NetworkNKAIN2
Wikipedia pathwaysNKAIN2
Orthology - Evolution
OrthoDB154215
GeneTree (enSembl)ENSG00000188580
Phylogenetic Trees/Animal Genes : TreeFamNKAIN2
Homologs : HomoloGeneNKAIN2
Homology/Alignments : Family Browser (UCSC)NKAIN2
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K5/NKAIN2 [6q23.3/6q22.31]  
Fusion : MitelmanNKAIN2/MS4A12 [6q22.31/11q12.2]  
Fusion : MitelmanSENP6/NKAIN2 [6q14.1/6q22.31]  
Fusion : MitelmanSNX14/NKAIN2 [6q14.3/6q22.31]  
Fusion : QuiverNKAIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKAIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKAIN2
dbVarNKAIN2
ClinVarNKAIN2
MonarchNKAIN2
1000_GenomesNKAIN2 
Exome Variant ServerNKAIN2
GNOMAD BrowserENSG00000188580
Varsome BrowserNKAIN2
ACMGNKAIN2 variants
VarityQ5VXU1
Genomic Variants (DGV)NKAIN2 [DGVbeta]
DECIPHERNKAIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKAIN2 
Mutations
ICGC Data PortalNKAIN2 
TCGA Data PortalNKAIN2 
Broad Tumor PortalNKAIN2
OASIS PortalNKAIN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKAIN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNKAIN2
Mutations and Diseases : HGMDNKAIN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNKAIN2
DgiDB (Drug Gene Interaction Database)NKAIN2
DoCM (Curated mutations)NKAIN2
CIViC (Clinical Interpretations of Variants in Cancer)NKAIN2
Cancer3DNKAIN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609758   
Orphanet
DisGeNETNKAIN2
MedgenNKAIN2
Genetic Testing Registry NKAIN2
NextProtQ5VXU1 [Medical]
GENETestsNKAIN2
Target ValidationNKAIN2
Huge Navigator NKAIN2 [HugePedia]
ClinGenNKAIN2
Clinical trials, drugs, therapy
MyCancerGenomeNKAIN2
Protein Interactions : CTDNKAIN2
Pharm GKB GenePA162397563
PharosQ5VXU1
Clinical trialNKAIN2
Miscellaneous
canSAR (ICR)NKAIN2
HarmonizomeNKAIN2
DataMed IndexNKAIN2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNKAIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:22:49 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.