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NKAIN2 (sodium/potassium transporting ATPase interacting 2)

Identity

Alias_namesTCBA1
T-cell lymphoma breakpoint associated target 1
Alias_symbol (synonym)FAM77B
Other aliasNKAIP2
TCBA
HGNC (Hugo) NKAIN2
LocusID (NCBI) 154215
Atlas_Id 42488
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 123803846 and ends at 124825640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / NKAIN2 (6q22.31)MAP3K5 (6q23.3) / NKAIN2 (6q22.31)MTHFD1L (6q25.1) / NKAIN2 (6q22.31)
NCOA7 (6q22.32) / NKAIN2 (6q22.31)NKAIN2 (6q22.31) / ETV6 (12p13.2)NKAIN2 (6q22.31) / MS4A12 (11q12.2)
NKAIN2 (6q22.31) / MYOT (5q31.2)NKAIN2 (6q22.31) / NEK1 (4q33)NKAIN2 (6q22.31) / RNF217 (6q22.31)
NKAIN2 (6q22.31) / SENP6 (6q14.1)SENP6 (6q14.1) / NKAIN2 (6q22.31)SNX14 (6q14.3) / NKAIN2 (6q22.31)
SRSF5 (14q24.2) / NKAIN2 (6q22.31)MAP3K5 6q23.3 / NKAIN2 6q22.31NKAIN2 6q22.31 / MS4A12 11q12.2
SNX14 6q14.3 / NKAIN2 6q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q21) SENP6/NKAIN2


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;6)(q14;q21) SNX14/NKAIN2
t(6;6)(q21;q23) MAP3K5/NKAIN2
t(6;11)(q21;q12) NKAIN2/MS4A12


External links

Nomenclature
HGNC (Hugo)NKAIN2   16443
Cards
Entrez_Gene (NCBI)NKAIN2  154215  sodium/potassium transporting ATPase interacting 2
AliasesFAM77B; NKAIP2; TCBA; TCBA1
GeneCards (Weizmann)NKAIN2
Ensembl hg19 (Hinxton)ENSG00000188580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188580 [Gene_View]  ENSG00000188580 [Sequence]  chr6:123803846-124825640 [Contig_View]  NKAIN2 [Vega]
ICGC DataPortalENSG00000188580
TCGA cBioPortalNKAIN2
AceView (NCBI)NKAIN2
Genatlas (Paris)NKAIN2
WikiGenes154215
SOURCE (Princeton)NKAIN2
Genetics Home Reference (NIH)NKAIN2
Genomic and cartography
GoldenPath hg38 (UCSC)NKAIN2  -     chr6:123803846-124825640 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKAIN2  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblNKAIN2 - 6q22.31 [CytoView hg19]  NKAIN2 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBINKAIN2 [Mapview hg19]  NKAIN2 [Mapview hg38]
OMIM609758   
Gene and transcription
Genbank (Entrez)AB070452 AK055326 AK308927 AK309385 AK309407
RefSeq transcript (Entrez)NM_001040214 NM_001300737 NM_001300738 NM_001300740 NM_153355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKAIN2
Cluster EST : UnigeneHs.656604 [ NCBI ]
CGAP (NCI)Hs.656604
Alternative Splicing GalleryENSG00000188580
Gene ExpressionNKAIN2 [ NCBI-GEO ]   NKAIN2 [ EBI - ARRAY_EXPRESS ]   NKAIN2 [ SEEK ]   NKAIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKAIN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154215
GTEX Portal (Tissue expression)NKAIN2
Human Protein AtlasENSG00000188580-NKAIN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VXU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VXU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VXU1
Splice isoforms : SwissVarQ5VXU1
PhosPhoSitePlusQ5VXU1
Domains : Interpro (EBI)Na/K-Atpase_Interacting   
Domain families : Pfam (Sanger)NKAIN (PF05640)   
Domain families : Pfam (NCBI)pfam05640   
Conserved Domain (NCBI)NKAIN2
DMDM Disease mutations154215
Blocks (Seattle)NKAIN2
SuperfamilyQ5VXU1
Human Protein Atlas [tissue]ENSG00000188580-NKAIN2 [tissue]
Peptide AtlasQ5VXU1
HPRD18168
IPIIPI00217845   IPI00479584   IPI00872155   IPI01014917   IPI00967131   
Protein Interaction databases
DIP (DOE-UCLA)Q5VXU1
IntAct (EBI)Q5VXU1
FunCoupENSG00000188580
BioGRIDNKAIN2
STRING (EMBL)NKAIN2
ZODIACNKAIN2
Ontologies - Pathways
QuickGOQ5VXU1
Ontology : AmiGOregulation of sodium ion transport  plasma membrane  integral component of membrane  
Ontology : EGO-EBIregulation of sodium ion transport  plasma membrane  integral component of membrane  
NDEx NetworkNKAIN2
Atlas of Cancer Signalling NetworkNKAIN2
Wikipedia pathwaysNKAIN2
Orthology - Evolution
OrthoDB154215
GeneTree (enSembl)ENSG00000188580
Phylogenetic Trees/Animal Genes : TreeFamNKAIN2
HOVERGENQ5VXU1
HOGENOMQ5VXU1
Homologs : HomoloGeneNKAIN2
Homology/Alignments : Family Browser (UCSC)NKAIN2
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K5/NKAIN2 [6q23.3/6q22.31]  [t(6;6)(q21;q23)]  
Fusion : MitelmanNKAIN2/MS4A12 [6q22.31/11q12.2]  [t(6;11)(q21;q12)]  
Fusion : MitelmanSENP6/NKAIN2 [6q14.1/6q22.31]  [t(6;6)(q14;q21)]  
Fusion : MitelmanSNX14/NKAIN2 [6q14.3/6q22.31]  [t(6;6)(q14;q21)]  
Fusion PortalMAP3K5 6q23.3 NKAIN2 6q22.31 LUSC
Fusion PortalNKAIN2 6q22.31 MS4A12 11q12.2 LUSC
Fusion PortalSNX14 6q14.3 NKAIN2 6q22.31 BRCA
Fusion : QuiverNKAIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKAIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKAIN2
dbVarNKAIN2
ClinVarNKAIN2
1000_GenomesNKAIN2 
Exome Variant ServerNKAIN2
ExAC (Exome Aggregation Consortium)ENSG00000188580
GNOMAD BrowserENSG00000188580
Varsome BrowserNKAIN2
Genetic variants : HAPMAP154215
Genomic Variants (DGV)NKAIN2 [DGVbeta]
DECIPHERNKAIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKAIN2 
Mutations
ICGC Data PortalNKAIN2 
TCGA Data PortalNKAIN2 
Broad Tumor PortalNKAIN2
OASIS PortalNKAIN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKAIN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKAIN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKAIN2
DgiDB (Drug Gene Interaction Database)NKAIN2
DoCM (Curated mutations)NKAIN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKAIN2 (select a term)
intoGenNKAIN2
Cancer3DNKAIN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609758   
Orphanet
DisGeNETNKAIN2
MedgenNKAIN2
Genetic Testing Registry NKAIN2
NextProtQ5VXU1 [Medical]
TSGene154215
GENETestsNKAIN2
Target ValidationNKAIN2
Huge Navigator NKAIN2 [HugePedia]
snp3D : Map Gene to Disease154215
BioCentury BCIQNKAIN2
ClinGenNKAIN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD154215
Chemical/Pharm GKB GenePA162397563
Clinical trialNKAIN2
Miscellaneous
canSAR (ICR)NKAIN2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKAIN2
EVEXNKAIN2
GoPubMedNKAIN2
iHOPNKAIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:26:16 CET 2018

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