NKAPL (NFKB activating protein like)

2014-11-01  

Identity

HGNC
NKAPL
LOCATION
6p22.1
LOCUSID
222698
ALIAS
C6orf194,bA424I5.1

Other Information

Locus ID:

NCBI: 222698
HGNC: 21584
Ensembl: ENSG00000189134

Variants:

dbSNP: 222698
ClinVar: 222698
TCGA: ENSG00000189134
COSMIC: NKAPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189134ENST00000343684Q5M9Q1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
220375522011Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.95
249727562014Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia.5
232234222013Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.4
258750952015A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.4
280954832017Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese.3
262971232015Further evidence supporting the association of NKAPL with schizophrenia.2

Citation

Dessen P

NKAPL (NFKB activating protein like)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70849/nkapl