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NKX1-2 (NK1 homeobox 2)

Identity

Alias (NCBI)C10orf121
NKX-1.1
bB238F13.2
HGNC (Hugo) NKX1-2
HGNC Alias symbbB238F13.2
HGNC Previous nameC10orf121
HGNC Previous namechromosome 10 open reading frame 121
 NK1 transcription factor related, locus 2 (Drosophila)
LocusID (NCBI) 390010
Atlas_Id 70855
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 124445244 and ends at 124450035 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NKX1-2   31652
Cards
Entrez_Gene (NCBI)NKX1-2    NK1 homeobox 2
AliasesC10orf121; NKX-1.1; bB238F13.2
GeneCards (Weizmann)NKX1-2
Ensembl hg19 (Hinxton)ENSG00000229544 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000229544 [Gene_View]  ENSG00000229544 [Sequence]  chr10:124445244-124450035 [Contig_View]  NKX1-2 [Vega]
ICGC DataPortalENSG00000229544
TCGA cBioPortalNKX1-2
AceView (NCBI)NKX1-2
Genatlas (Paris)NKX1-2
SOURCE (Princeton)NKX1-2
Genetics Home Reference (NIH)NKX1-2
Genomic and cartography
GoldenPath hg38 (UCSC)NKX1-2  -     chr10:124445244-124450035 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX1-2  -     10q26.13   [Description]    (hg19-Feb_2009)
GoldenPathNKX1-2 - 10q26.13 [CytoView hg19]  NKX1-2 - 10q26.13 [CytoView hg38]
ImmunoBaseENSG00000229544
Genome Data Viewer NCBINKX1-2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)BX092002
RefSeq transcript (Entrez)NM_001146340
Consensus coding sequences : CCDS (NCBI)NKX1-2
Gene ExpressionNKX1-2 [ NCBI-GEO ]   NKX1-2 [ EBI - ARRAY_EXPRESS ]   NKX1-2 [ SEEK ]   NKX1-2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX1-2 [ Firebrowse - Broad ]
GenevisibleExpression of NKX1-2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)390010
GTEX Portal (Tissue expression)NKX1-2
Human Protein AtlasENSG00000229544-NKX1-2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UD57   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UD57  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UD57
PhosPhoSitePlusQ9UD57
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX1-2
SuperfamilyQ9UD57
AlphaFold pdb e-kbQ9UD57   
Human Protein Atlas [tissue]ENSG00000229544-NKX1-2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9UD57
IntAct (EBI)Q9UD57
BioGRIDNKX1-2
STRING (EMBL)NKX1-2
ZODIACNKX1-2
Ontologies - Pathways
QuickGOQ9UD57
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  multicellular organism development  cell differentiation  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  multicellular organism development  cell differentiation  
NDEx NetworkNKX1-2
Atlas of Cancer Signalling NetworkNKX1-2
Wikipedia pathwaysNKX1-2
Orthology - Evolution
OrthoDB390010
GeneTree (enSembl)ENSG00000229544
Phylogenetic Trees/Animal Genes : TreeFamNKX1-2
Homologs : HomoloGeneNKX1-2
Homology/Alignments : Family Browser (UCSC)NKX1-2
Gene fusions - Rearrangements
Fusion : QuiverNKX1-2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX1-2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX1-2
dbVarNKX1-2
ClinVarNKX1-2
MonarchNKX1-2
1000_GenomesNKX1-2 
Exome Variant ServerNKX1-2
GNOMAD BrowserENSG00000229544
Varsome BrowserNKX1-2
ACMGNKX1-2 variants
VarityQ9UD57
Genomic Variants (DGV)NKX1-2 [DGVbeta]
DECIPHERNKX1-2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX1-2 
Mutations
ICGC Data PortalNKX1-2 
TCGA Data PortalNKX1-2 
Broad Tumor PortalNKX1-2
OASIS PortalNKX1-2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX1-2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNKX1-2
Mutations and Diseases : HGMDNKX1-2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNKX1-2
DgiDB (Drug Gene Interaction Database)NKX1-2
DoCM (Curated mutations)NKX1-2
CIViC (Clinical Interpretations of Variants in Cancer)NKX1-2
Cancer3DNKX1-2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETNKX1-2
MedgenNKX1-2
Genetic Testing Registry NKX1-2
NextProtQ9UD57 [Medical]
GENETestsNKX1-2
Target ValidationNKX1-2
Huge Navigator NKX1-2 [HugePedia]
ClinGenNKX1-2
Clinical trials, drugs, therapy
MyCancerGenomeNKX1-2
Protein Interactions : CTDNKX1-2
Pharm GKB GenePA134977174
PharosQ9UD57
Clinical trialNKX1-2
Miscellaneous
canSAR (ICR)NKX1-2
HarmonizomeNKX1-2
DataMed IndexNKX1-2
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNKX1-2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:47 CEST 2021

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