Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NKX2-6 (NK2 homeobox 6)

Identity

Alias_namesNK2 transcription factor related
Alias_symbol (synonym)CSX2
NKX4-2
Other aliasCTHM
NKX2F
HGNC (Hugo) NKX2-6
LocusID (NCBI) 137814
Atlas_Id 56158
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 23702451 and ends at 23706598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NKX2-6   32940
Cards
Entrez_Gene (NCBI)NKX2-6  137814  NK2 homeobox 6
AliasesCSX2; CTHM; NKX2F; NKX4-2
GeneCards (Weizmann)NKX2-6
Ensembl hg19 (Hinxton)ENSG00000180053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180053 [Gene_View]  ENSG00000180053 [Sequence]  chr8:23702451-23706598 [Contig_View]  NKX2-6 [Vega]
ICGC DataPortalENSG00000180053
TCGA cBioPortalNKX2-6
AceView (NCBI)NKX2-6
Genatlas (Paris)NKX2-6
WikiGenes137814
SOURCE (Princeton)NKX2-6
Genetics Home Reference (NIH)NKX2-6
Genomic and cartography
GoldenPath hg38 (UCSC)NKX2-6  -     chr8:23702451-23706598 -  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX2-6  -     8p21.2   [Description]    (hg19-Feb_2009)
NKX2-6 - 8p21.2 [CytoView hg19]  NKX2-6 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBINKX2-6 [Mapview hg19]  NKX2-6 [Mapview hg38]
OMIM217095   611770   
Gene and transcription
Genbank (Entrez)CN272646
RefSeq transcript (Entrez)NM_001136271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX2-6
Cluster EST : UnigeneHs.532654 [ NCBI ]
CGAP (NCI)Hs.532654
Alternative Splicing GalleryENSG00000180053
Gene ExpressionNKX2-6 [ NCBI-GEO ]   NKX2-6 [ EBI - ARRAY_EXPRESS ]   NKX2-6 [ SEEK ]   NKX2-6 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX2-6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137814
GTEX Portal (Tissue expression)NKX2-6
Human Protein AtlasENSG00000180053-NKX2-6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NCS4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NCS4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NCS4
Splice isoforms : SwissVarA6NCS4
PhosPhoSitePlusA6NCS4
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX2-6
DMDM Disease mutations137814
Blocks (Seattle)NKX2-6
SuperfamilyA6NCS4
Human Protein Atlas [tissue]ENSG00000180053-NKX2-6 [tissue]
Peptide AtlasA6NCS4
IPIIPI00887927   IPI00939893   
Protein Interaction databases
DIP (DOE-UCLA)A6NCS4
IntAct (EBI)A6NCS4
FunCoupENSG00000180053
BioGRIDNKX2-6
STRING (EMBL)NKX2-6
ZODIACNKX2-6
Ontologies - Pathways
QuickGOA6NCS4
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  positive regulation of cell proliferation  hypothalamus development  cell differentiation  cell differentiation  embryonic heart tube development  embryonic heart tube development  negative regulation of apoptotic process  sequence-specific DNA binding  tongue development  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  digestive tract development  atrial cardiac muscle cell development  ventricular cardiac muscle cell development  pharyngeal system development  pericardium development  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  positive regulation of cell proliferation  hypothalamus development  cell differentiation  cell differentiation  embryonic heart tube development  embryonic heart tube development  negative regulation of apoptotic process  sequence-specific DNA binding  tongue development  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  digestive tract development  atrial cardiac muscle cell development  ventricular cardiac muscle cell development  pharyngeal system development  pericardium development  
NDEx NetworkNKX2-6
Atlas of Cancer Signalling NetworkNKX2-6
Wikipedia pathwaysNKX2-6
Orthology - Evolution
OrthoDB137814
GeneTree (enSembl)ENSG00000180053
Phylogenetic Trees/Animal Genes : TreeFamNKX2-6
HOGENOMA6NCS4
Homologs : HomoloGeneNKX2-6
Homology/Alignments : Family Browser (UCSC)NKX2-6
Gene fusions - Rearrangements
Fusion : QuiverNKX2-6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX2-6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX2-6
dbVarNKX2-6
ClinVarNKX2-6
1000_GenomesNKX2-6 
Exome Variant ServerNKX2-6
ExAC (Exome Aggregation Consortium)ENSG00000180053
GNOMAD BrowserENSG00000180053
Varsome BrowserNKX2-6
Genetic variants : HAPMAP137814
Genomic Variants (DGV)NKX2-6 [DGVbeta]
DECIPHERNKX2-6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX2-6 
Mutations
ICGC Data PortalNKX2-6 
TCGA Data PortalNKX2-6 
Broad Tumor PortalNKX2-6
OASIS PortalNKX2-6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX2-6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX2-6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX2-6
DgiDB (Drug Gene Interaction Database)NKX2-6
DoCM (Curated mutations)NKX2-6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX2-6 (select a term)
intoGenNKX2-6
Cancer3DNKX2-6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM217095    611770   
Orphanet820    2997    8592    14114   
DisGeNETNKX2-6
MedgenNKX2-6
Genetic Testing Registry NKX2-6
NextProtA6NCS4 [Medical]
TSGene137814
GENETestsNKX2-6
Target ValidationNKX2-6
Huge Navigator NKX2-6 [HugePedia]
snp3D : Map Gene to Disease137814
BioCentury BCIQNKX2-6
ClinGenNKX2-6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137814
Chemical/Pharm GKB GenePA145148392
Clinical trialNKX2-6
Miscellaneous
canSAR (ICR)NKX2-6 (select the gene name)
DataMed IndexNKX2-6
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX2-6
EVEXNKX2-6
GoPubMedNKX2-6
iHOPNKX2-6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu May 2 13:01:56 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.