Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NKX2-6 (NK2 homeobox 6)

Identity

Alias_namesNK2 transcription factor related
Alias_symbol (synonym)CSX2
NKX4-2
Other aliasCTHM
NKX2F
HGNC (Hugo) NKX2-6
LocusID (NCBI) 137814
Atlas_Id 56158
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 23702451 and ends at 23706598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NKX2-6   32940
Cards
Entrez_Gene (NCBI)NKX2-6  137814  NK2 homeobox 6
AliasesCSX2; CTHM; NKX2F; NKX4-2
GeneCards (Weizmann)NKX2-6
Ensembl hg19 (Hinxton)ENSG00000180053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180053 [Gene_View]  chr8:23702451-23706598 [Contig_View]  NKX2-6 [Vega]
ICGC DataPortalENSG00000180053
TCGA cBioPortalNKX2-6
AceView (NCBI)NKX2-6
Genatlas (Paris)NKX2-6
WikiGenes137814
SOURCE (Princeton)NKX2-6
Genetics Home Reference (NIH)NKX2-6
Genomic and cartography
GoldenPath hg38 (UCSC)NKX2-6  -     chr8:23702451-23706598 -  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX2-6  -     8p21.2   [Description]    (hg19-Feb_2009)
EnsemblNKX2-6 - 8p21.2 [CytoView hg19]  NKX2-6 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBINKX2-6 [Mapview hg19]  NKX2-6 [Mapview hg38]
OMIM217095   611770   
Gene and transcription
Genbank (Entrez)AB464642 CN272646
RefSeq transcript (Entrez)NM_001136271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX2-6
Cluster EST : UnigeneHs.532654 [ NCBI ]
CGAP (NCI)Hs.532654
Alternative Splicing GalleryENSG00000180053
Gene ExpressionNKX2-6 [ NCBI-GEO ]   NKX2-6 [ EBI - ARRAY_EXPRESS ]   NKX2-6 [ SEEK ]   NKX2-6 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX2-6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137814
GTEX Portal (Tissue expression)NKX2-6
Human Protein AtlasENSG00000180053-NKX2-6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NCS4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NCS4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NCS4
Splice isoforms : SwissVarA6NCS4
PhosPhoSitePlusA6NCS4
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX2-6
DMDM Disease mutations137814
Blocks (Seattle)NKX2-6
SuperfamilyA6NCS4
Human Protein Atlas [tissue]ENSG00000180053-NKX2-6 [tissue]
Peptide AtlasA6NCS4
IPIIPI00887927   IPI00939893   
Protein Interaction databases
DIP (DOE-UCLA)A6NCS4
IntAct (EBI)A6NCS4
FunCoupENSG00000180053
BioGRIDNKX2-6
STRING (EMBL)NKX2-6
ZODIACNKX2-6
Ontologies - Pathways
QuickGOA6NCS4
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  positive regulation of cell proliferation  hypothalamus development  cell differentiation  embryonic heart tube development  embryonic heart tube development  negative regulation of apoptotic process  sequence-specific DNA binding  tongue development  digestive tract development  atrial cardiac muscle cell development  ventricular cardiac muscle cell development  pharyngeal system development  pericardium development  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  positive regulation of cell proliferation  hypothalamus development  cell differentiation  embryonic heart tube development  embryonic heart tube development  negative regulation of apoptotic process  sequence-specific DNA binding  tongue development  digestive tract development  atrial cardiac muscle cell development  ventricular cardiac muscle cell development  pharyngeal system development  pericardium development  
NDEx NetworkNKX2-6
Atlas of Cancer Signalling NetworkNKX2-6
Wikipedia pathwaysNKX2-6
Orthology - Evolution
OrthoDB137814
GeneTree (enSembl)ENSG00000180053
Phylogenetic Trees/Animal Genes : TreeFamNKX2-6
HOVERGENA6NCS4
HOGENOMA6NCS4
Homologs : HomoloGeneNKX2-6
Homology/Alignments : Family Browser (UCSC)NKX2-6
Gene fusions - Rearrangements
Tumor Fusion PortalNKX2-6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX2-6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX2-6
dbVarNKX2-6
ClinVarNKX2-6
1000_GenomesNKX2-6 
Exome Variant ServerNKX2-6
ExAC (Exome Aggregation Consortium)ENSG00000180053
GNOMAD BrowserENSG00000180053
Genetic variants : HAPMAP137814
Genomic Variants (DGV)NKX2-6 [DGVbeta]
DECIPHERNKX2-6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX2-6 
Mutations
ICGC Data PortalNKX2-6 
TCGA Data PortalNKX2-6 
Broad Tumor PortalNKX2-6
OASIS PortalNKX2-6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX2-6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX2-6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX2-6
DgiDB (Drug Gene Interaction Database)NKX2-6
DoCM (Curated mutations)NKX2-6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX2-6 (select a term)
intoGenNKX2-6
Cancer3DNKX2-6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM217095    611770   
Orphanet820    2997    8592    14114   
DisGeNETNKX2-6
MedgenNKX2-6
Genetic Testing Registry NKX2-6
NextProtA6NCS4 [Medical]
TSGene137814
GENETestsNKX2-6
Target ValidationNKX2-6
Huge Navigator NKX2-6 [HugePedia]
snp3D : Map Gene to Disease137814
BioCentury BCIQNKX2-6
ClinGenNKX2-6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137814
Chemical/Pharm GKB GenePA145148392
Clinical trialNKX2-6
Miscellaneous
canSAR (ICR)NKX2-6 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX2-6
EVEXNKX2-6
GoPubMedNKX2-6
iHOPNKX2-6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:26:19 CET 2017

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