Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NKX2-8 (NK2 homeobox 8)

Identity

Alias_namesNKX2H
NK-2 homolog H (Drosophila)
NK2 transcription factor related, locus 8 (Drosophila)
Alias_symbol (synonym)NKX2.8
Nkx2-9
Other alias
HGNC (Hugo) NKX2-8
LocusID (NCBI) 26257
Atlas_Id 50867
Location 14q13.3  [Link to chromosome band 14q13]
Location_base_pair Starts at 36580011 and ends at 36582614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NKX2-8   16364
Cards
Entrez_Gene (NCBI)NKX2-8  26257  NK2 homeobox 8
AliasesNKX2.8; NKX2H; Nkx2-9
GeneCards (Weizmann)NKX2-8
Ensembl hg19 (Hinxton)ENSG00000136327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136327 [Gene_View]  ENSG00000136327 [Sequence]  chr14:36580011-36582614 [Contig_View]  NKX2-8 [Vega]
ICGC DataPortalENSG00000136327
TCGA cBioPortalNKX2-8
AceView (NCBI)NKX2-8
Genatlas (Paris)NKX2-8
WikiGenes26257
SOURCE (Princeton)NKX2-8
Genetics Home Reference (NIH)NKX2-8
Genomic and cartography
GoldenPath hg38 (UCSC)NKX2-8  -     chr14:36580011-36582614 -  14q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX2-8  -     14q13.3   [Description]    (hg19-Feb_2009)
EnsemblNKX2-8 - 14q13.3 [CytoView hg19]  NKX2-8 - 14q13.3 [CytoView hg38]
Mapping of homologs : NCBINKX2-8 [Mapview hg19]  NKX2-8 [Mapview hg38]
OMIM603245   
Gene and transcription
Genbank (Entrez)AF000295 AK313537 BC041090 DA438523
RefSeq transcript (Entrez)NM_014360
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX2-8
Cluster EST : UnigeneHs.234763 [ NCBI ]
CGAP (NCI)Hs.234763
Alternative Splicing GalleryENSG00000136327
Gene ExpressionNKX2-8 [ NCBI-GEO ]   NKX2-8 [ EBI - ARRAY_EXPRESS ]   NKX2-8 [ SEEK ]   NKX2-8 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX2-8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26257
GTEX Portal (Tissue expression)NKX2-8
Human Protein AtlasENSG00000136327-NKX2-8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15522   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15522  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15522
Splice isoforms : SwissVarO15522
PhosPhoSitePlusO15522
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX2-8
DMDM Disease mutations26257
Blocks (Seattle)NKX2-8
SuperfamilyO15522
Human Protein Atlas [tissue]ENSG00000136327-NKX2-8 [tissue]
Peptide AtlasO15522
HPRD04456
IPIIPI00007308   
Protein Interaction databases
DIP (DOE-UCLA)O15522
IntAct (EBI)O15522
FunCoupENSG00000136327
BioGRIDNKX2-8
STRING (EMBL)NKX2-8
ZODIACNKX2-8
Ontologies - Pathways
QuickGOO15522
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  double-stranded DNA binding  DNA-binding transcription factor activity  cellular_component  nucleus  transcription, DNA-templated  transcription by RNA polymerase II  axonogenesis  lung development  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  negative regulation of epithelial cell proliferation  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  double-stranded DNA binding  DNA-binding transcription factor activity  cellular_component  nucleus  transcription, DNA-templated  transcription by RNA polymerase II  axonogenesis  lung development  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  negative regulation of epithelial cell proliferation  
NDEx NetworkNKX2-8
Atlas of Cancer Signalling NetworkNKX2-8
Wikipedia pathwaysNKX2-8
Orthology - Evolution
OrthoDB26257
GeneTree (enSembl)ENSG00000136327
Phylogenetic Trees/Animal Genes : TreeFamNKX2-8
HOVERGENO15522
HOGENOMO15522
Homologs : HomoloGeneNKX2-8
Homology/Alignments : Family Browser (UCSC)NKX2-8
Gene fusions - Rearrangements
Fusion : QuiverNKX2-8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX2-8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX2-8
dbVarNKX2-8
ClinVarNKX2-8
1000_GenomesNKX2-8 
Exome Variant ServerNKX2-8
ExAC (Exome Aggregation Consortium)ENSG00000136327
GNOMAD BrowserENSG00000136327
Varsome BrowserNKX2-8
Genetic variants : HAPMAP26257
Genomic Variants (DGV)NKX2-8 [DGVbeta]
DECIPHERNKX2-8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX2-8 
Mutations
ICGC Data PortalNKX2-8 
TCGA Data PortalNKX2-8 
Broad Tumor PortalNKX2-8
OASIS PortalNKX2-8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX2-8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX2-8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX2-8
DgiDB (Drug Gene Interaction Database)NKX2-8
DoCM (Curated mutations)NKX2-8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX2-8 (select a term)
intoGenNKX2-8
Cancer3DNKX2-8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603245   
Orphanet
DisGeNETNKX2-8
MedgenNKX2-8
Genetic Testing Registry NKX2-8
NextProtO15522 [Medical]
TSGene26257
GENETestsNKX2-8
Target ValidationNKX2-8
Huge Navigator NKX2-8 [HugePedia]
snp3D : Map Gene to Disease26257
BioCentury BCIQNKX2-8
ClinGenNKX2-8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26257
Chemical/Pharm GKB GenePA38402
Clinical trialNKX2-8
Miscellaneous
canSAR (ICR)NKX2-8 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX2-8
EVEXNKX2-8
GoPubMedNKX2-8
iHOPNKX2-8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 11:26:19 CET 2018
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