Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NKX3-2 (NK3 homeobox 2)

Identity

Other aliasBAPX1
NKX3.2
NKX3B
SMMD
HGNC (Hugo) NKX3-2
LocusID (NCBI) 579
Atlas_Id 57013
Location 4p15.33  [Link to chromosome band 4p15]
Location_base_pair Starts at 13540830 and ends at 13544490 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NKX3-2   951
Cards
Entrez_Gene (NCBI)NKX3-2  579  NK3 homeobox 2
AliasesBAPX1; NKX3.2; NKX3B; SMMD
GeneCards (Weizmann)NKX3-2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:13540830-13544490 [Contig_View]  NKX3-2 [Vega]
TCGA cBioPortalNKX3-2
AceView (NCBI)NKX3-2
Genatlas (Paris)NKX3-2
WikiGenes579
SOURCE (Princeton)NKX3-2
Genetics Home Reference (NIH)NKX3-2
Genomic and cartography
GoldenPath hg38 (UCSC)NKX3-2  -     chr4:13540830-13544490 -  4p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX3-2  -     4p15.33   [Description]    (hg19-Feb_2009)
EnsemblNKX3-2 - 4p15.33 [CytoView hg19]  NKX3-2 - 4p15.33 [CytoView hg38]
Mapping of homologs : NCBINKX3-2 [Mapview hg19]  NKX3-2 [Mapview hg38]
OMIM602183   613330   
Gene and transcription
Genbank (Entrez)AF009801 BC111966
RefSeq transcript (Entrez)NM_001189
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX3-2
Cluster EST : UnigeneHs.590927 [ NCBI ]
CGAP (NCI)Hs.590927
Gene ExpressionNKX3-2 [ NCBI-GEO ]   NKX3-2 [ EBI - ARRAY_EXPRESS ]   NKX3-2 [ SEEK ]   NKX3-2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX3-2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)579
GTEX Portal (Tissue expression)NKX3-2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78367   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78367  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78367
Splice isoforms : SwissVarP78367
PhosPhoSitePlusP78367
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX3-2
DMDM Disease mutations579
Blocks (Seattle)NKX3-2
SuperfamilyP78367
Peptide AtlasP78367
IPIIPI00019228   
Protein Interaction databases
DIP (DOE-UCLA)P78367
IntAct (EBI)P78367
BioGRIDNKX3-2
STRING (EMBL)NKX3-2
ZODIACNKX3-2
Ontologies - Pathways
QuickGOP78367
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  skeletal system development  nucleus  transcription by RNA polymerase II  determination of left/right symmetry  pancreas development  negative regulation of chondrocyte differentiation  middle ear morphogenesis  negative regulation of apoptotic process  spleen development  animal organ formation  skeletal system morphogenesis  embryonic skeletal system development  intestinal epithelial cell development  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  skeletal system development  nucleus  transcription by RNA polymerase II  determination of left/right symmetry  pancreas development  negative regulation of chondrocyte differentiation  middle ear morphogenesis  negative regulation of apoptotic process  spleen development  animal organ formation  skeletal system morphogenesis  embryonic skeletal system development  intestinal epithelial cell development  
NDEx NetworkNKX3-2
Atlas of Cancer Signalling NetworkNKX3-2
Wikipedia pathwaysNKX3-2
Orthology - Evolution
OrthoDB579
Phylogenetic Trees/Animal Genes : TreeFamNKX3-2
HOVERGENP78367
HOGENOMP78367
Homologs : HomoloGeneNKX3-2
Homology/Alignments : Family Browser (UCSC)NKX3-2
Gene fusions - Rearrangements
Fusion : QuiverNKX3-2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX3-2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX3-2
dbVarNKX3-2
ClinVarNKX3-2
1000_GenomesNKX3-2 
Exome Variant ServerNKX3-2
Genetic variants : HAPMAP579
Genomic Variants (DGV)NKX3-2 [DGVbeta]
DECIPHERNKX3-2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX3-2 
Mutations
ICGC Data PortalNKX3-2 
TCGA Data PortalNKX3-2 
Broad Tumor PortalNKX3-2
OASIS PortalNKX3-2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX3-2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX3-2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX3-2
DgiDB (Drug Gene Interaction Database)NKX3-2
DoCM (Curated mutations)NKX3-2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX3-2 (select a term)
intoGenNKX3-2
Cancer3DNKX3-2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602183    613330   
Orphanet
DisGeNETNKX3-2
MedgenNKX3-2
Genetic Testing Registry NKX3-2
NextProtP78367 [Medical]
TSGene579
GENETestsNKX3-2
Target ValidationNKX3-2
Huge Navigator NKX3-2 [HugePedia]
snp3D : Map Gene to Disease579
BioCentury BCIQNKX3-2
ClinGenNKX3-2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD579
Chemical/Pharm GKB GenePA162397617
Clinical trialNKX3-2
Miscellaneous
canSAR (ICR)NKX3-2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX3-2
EVEXNKX3-2
GoPubMedNKX3-2
iHOPNKX3-2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Feb 28 13:27:50 CET 2018
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