| Nomenclature |
|---|
| HGNC (Hugo) | NKX3-2 951 |
| Cards |
|---|
| Entrez_Gene (NCBI) | NKX3-2 579 NK3 homeobox 2 |
| Aliases | BAPX1; NKX3.2; NKX3B; SMMD |
| GeneCards (Weizmann) | NKX3-2 |
| Ensembl hg19 (Hinxton) | ENSG00000109705 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000109705 [Gene_View] ENSG00000109705 [Sequence] chr4:13540830-13544490 [Contig_View] NKX3-2 [Vega] |
| ICGC DataPortal | ENSG00000109705 |
| TCGA cBioPortal | NKX3-2 |
| AceView (NCBI) | NKX3-2 |
| Genatlas (Paris) | NKX3-2 |
| WikiGenes | 579 |
| SOURCE (Princeton) | NKX3-2 |
| Genetics Home Reference (NIH) | NKX3-2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | NKX3-2 - chr4:13540830-13544490 - 4p15.33 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | NKX3-2 - 4p15.33 [Description] (hg19-Feb_2009) |
| Ensembl | NKX3-2 - 4p15.33 [CytoView hg19] NKX3-2 - 4p15.33 [CytoView hg38] |
| Mapping of homologs : NCBI | NKX3-2 [Mapview hg19] NKX3-2 [Mapview hg38] |
| OMIM | 602183 613330 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF009801 BC111966 |
| RefSeq transcript (Entrez) | NM_001189 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | NKX3-2 |
| Cluster EST : Unigene | Hs.590927 [ NCBI ] |
| CGAP (NCI) | Hs.590927 |
| Alternative Splicing Gallery | ENSG00000109705 |
| Gene Expression | NKX3-2 [ NCBI-GEO ] NKX3-2 [ EBI - ARRAY_EXPRESS ]
NKX3-2 [ SEEK ] NKX3-2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | NKX3-2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 579 |
| GTEX Portal (Tissue expression) | NKX3-2 |
| Human Protein Atlas | ENSG00000109705-NKX3-2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P78367 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P78367 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P78367 |
| Splice isoforms : SwissVar | P78367 |
| PhosPhoSitePlus | P78367 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Homeobox-like_sf Homeobox_CS Homeobox_dom Homeobox_metazoa |
| Domain families : Pfam (Sanger) | Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| Conserved Domain (NCBI) | NKX3-2 |
| DMDM Disease mutations | 579 |
| Blocks (Seattle) | NKX3-2 |
| Superfamily | P78367 |
| Human Protein Atlas [tissue] | ENSG00000109705-NKX3-2 [tissue] |
| Peptide Atlas | P78367 |
| IPI | IPI00019228 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P78367 |
| IntAct (EBI) | P78367 |
| FunCoup | ENSG00000109705 |
| BioGRID | NKX3-2 |
| STRING (EMBL) | NKX3-2 |
| ZODIAC | NKX3-2 |
| Ontologies - Pathways |
|---|
| QuickGO | P78367 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development nucleus transcription by RNA polymerase II determination of left/right symmetry pancreas development negative regulation of chondrocyte differentiation middle ear morphogenesis negative regulation of apoptotic process spleen development animal organ formation skeletal system morphogenesis embryonic skeletal system development intestinal epithelial cell development |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development nucleus transcription by RNA polymerase II determination of left/right symmetry pancreas development negative regulation of chondrocyte differentiation middle ear morphogenesis negative regulation of apoptotic process spleen development animal organ formation skeletal system morphogenesis embryonic skeletal system development intestinal epithelial cell development |
| NDEx Network | NKX3-2 |
| Atlas of Cancer Signalling Network | NKX3-2 |
| Wikipedia pathways | NKX3-2 |
| Orthology - Evolution |
|---|
| OrthoDB | 579 |
| GeneTree (enSembl) | ENSG00000109705 |
| Phylogenetic Trees/Animal Genes : TreeFam | NKX3-2 |
| HOVERGEN | P78367 |
| HOGENOM | P78367 |
| Homologs : HomoloGene | NKX3-2 |
| Homology/Alignments : Family Browser (UCSC) | NKX3-2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | NKX3-2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | NKX3-2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | NKX3-2 |
| dbVar | NKX3-2 |
| ClinVar | NKX3-2 |
| 1000_Genomes | NKX3-2 |
| Exome Variant Server | NKX3-2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000109705 |
| GNOMAD Browser | ENSG00000109705 |
| Varsome Browser | NKX3-2 |
| Genetic variants : HAPMAP | 579 |
| Genomic Variants (DGV) | NKX3-2 [DGVbeta] |
| DECIPHER | NKX3-2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | NKX3-2 |
| Mutations |
|---|
| ICGC Data Portal | NKX3-2 |
| TCGA Data Portal | NKX3-2 |
| Broad Tumor Portal | NKX3-2 |
| OASIS Portal | NKX3-2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | NKX3-2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | NKX3-2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search NKX3-2 |
| DgiDB (Drug Gene Interaction Database) | NKX3-2 |
| DoCM (Curated mutations) | NKX3-2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | NKX3-2 (select a term) |
| intoGen | NKX3-2 |
| Cancer3D | NKX3-2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602183 613330 |
| Orphanet | |
| DisGeNET | NKX3-2 |
| Medgen | NKX3-2 |
| Genetic Testing Registry | NKX3-2
|
| NextProt | P78367 [Medical] |
| TSGene | 579 |
| GENETests | NKX3-2 |
| Target Validation | NKX3-2 |
| Huge Navigator |
NKX3-2 [HugePedia] |
| snp3D : Map Gene to Disease | 579 |
| BioCentury BCIQ | NKX3-2 |
| ClinGen | NKX3-2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 579 |
| Chemical/Pharm GKB Gene | PA162397617 |
| Clinical trial | NKX3-2 |
| Miscellaneous |
|---|
| canSAR (ICR) | NKX3-2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 18 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | NKX3-2 |
| EVEX | NKX3-2 |
| GoPubMed | NKX3-2 |
| iHOP | NKX3-2 |
