| Nomenclature |
|---|
| HGNC (Hugo) | NKX3-2 951 |
| Cards |
|---|
| Entrez_Gene (NCBI) | NKX3-2 579 NK3 homeobox 2 |
| Aliases | BAPX1; NKX3.2; NKX3B; SMMD |
| GeneCards (Weizmann) | NKX3-2 |
| Ensembl hg19 (Hinxton) | ENSG00000109705 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000109705 [Gene_View] ENSG00000109705 [Sequence] chr4:13540830-13544490 [Contig_View] NKX3-2 [Vega] |
| ICGC DataPortal | ENSG00000109705 |
| TCGA cBioPortal | NKX3-2 |
| AceView (NCBI) | NKX3-2 |
| Genatlas (Paris) | NKX3-2 |
| WikiGenes | 579 |
| SOURCE (Princeton) | NKX3-2 |
| Genetics Home Reference (NIH) | NKX3-2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | NKX3-2 - chr4:13540830-13544490 - 4p15.33 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | NKX3-2 - 4p15.33 [Description] (hg19-Feb_2009) |
| Ensembl | NKX3-2 - 4p15.33 [CytoView hg19] NKX3-2 - 4p15.33 [CytoView hg38] |
| Mapping of homologs : NCBI | NKX3-2 [Mapview hg19] NKX3-2 [Mapview hg38] |
| OMIM | 602183 613330 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF009801 BC111966 |
| RefSeq transcript (Entrez) | NM_001189 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | NKX3-2 |
| Cluster EST : Unigene | Hs.590927 [ NCBI ] |
| CGAP (NCI) | Hs.590927 |
| Alternative Splicing Gallery | ENSG00000109705 |
| Gene Expression | NKX3-2 [ NCBI-GEO ] NKX3-2 [ EBI - ARRAY_EXPRESS ]
NKX3-2 [ SEEK ] NKX3-2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | NKX3-2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 579 |
| GTEX Portal (Tissue expression) | NKX3-2 |
| Human Protein Atlas | ENSG00000109705-NKX3-2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P78367 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P78367 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P78367 |
| Splice isoforms : SwissVar | P78367 |
| PhosPhoSitePlus | P78367 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Homeobox-like_sf Homeobox_CS Homeobox_dom Homeobox_metazoa |
| Domain families : Pfam (Sanger) | Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| Conserved Domain (NCBI) | NKX3-2 |
| DMDM Disease mutations | 579 |
| Blocks (Seattle) | NKX3-2 |
| Superfamily | P78367 |
| Human Protein Atlas [tissue] | ENSG00000109705-NKX3-2 [tissue] |
| Peptide Atlas | P78367 |
| IPI | IPI00019228 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P78367 |
| IntAct (EBI) | P78367 |
| FunCoup | ENSG00000109705 |
| BioGRID | NKX3-2 |
| STRING (EMBL) | NKX3-2 |
| ZODIAC | NKX3-2 |
| Ontologies - Pathways |
|---|
| QuickGO | P78367 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development DNA-binding transcription factor activity nucleus nucleus transcription by RNA polymerase II determination of left/right symmetry cell differentiation pancreas development negative regulation of chondrocyte differentiation middle ear morphogenesis negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II spleen development animal organ formation skeletal system morphogenesis embryonic skeletal system development intestinal epithelial cell development |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development DNA-binding transcription factor activity nucleus nucleus transcription by RNA polymerase II determination of left/right symmetry cell differentiation pancreas development negative regulation of chondrocyte differentiation middle ear morphogenesis negative regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II spleen development animal organ formation skeletal system morphogenesis embryonic skeletal system development intestinal epithelial cell development |
| NDEx Network | NKX3-2 |
| Atlas of Cancer Signalling Network | NKX3-2 |
| Wikipedia pathways | NKX3-2 |
| Orthology - Evolution |
|---|
| OrthoDB | 579 |
| GeneTree (enSembl) | ENSG00000109705 |
| Phylogenetic Trees/Animal Genes : TreeFam | NKX3-2 |
| HOGENOM | P78367 |
| Homologs : HomoloGene | NKX3-2 |
| Homology/Alignments : Family Browser (UCSC) | NKX3-2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | NKX3-2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | NKX3-2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | NKX3-2 |
| dbVar | NKX3-2 |
| ClinVar | NKX3-2 |
| 1000_Genomes | NKX3-2 |
| Exome Variant Server | NKX3-2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000109705 |
| GNOMAD Browser | ENSG00000109705 |
| Varsome Browser | NKX3-2 |
| Genetic variants : HAPMAP | 579 |
| Genomic Variants (DGV) | NKX3-2 [DGVbeta] |
| DECIPHER | NKX3-2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | NKX3-2 |
| Mutations |
|---|
| ICGC Data Portal | NKX3-2 |
| TCGA Data Portal | NKX3-2 |
| Broad Tumor Portal | NKX3-2 |
| OASIS Portal | NKX3-2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | NKX3-2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | NKX3-2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search NKX3-2 |
| DgiDB (Drug Gene Interaction Database) | NKX3-2 |
| DoCM (Curated mutations) | NKX3-2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | NKX3-2 (select a term) |
| intoGen | NKX3-2 |
| Cancer3D | NKX3-2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602183 613330 |
| Orphanet | |
| DisGeNET | NKX3-2 |
| Medgen | NKX3-2 |
| Genetic Testing Registry | NKX3-2
|
| NextProt | P78367 [Medical] |
| TSGene | 579 |
| GENETests | NKX3-2 |
| Target Validation | NKX3-2 |
| Huge Navigator |
NKX3-2 [HugePedia] |
| snp3D : Map Gene to Disease | 579 |
| BioCentury BCIQ | NKX3-2 |
| ClinGen | NKX3-2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 579 |
| Chemical/Pharm GKB Gene | PA162397617 |
| Clinical trial | NKX3-2 |
| Miscellaneous |
|---|
| canSAR (ICR) | NKX3-2 (select the gene name) |
| DataMed Index | NKX3-2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 19 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | NKX3-2 |
| EVEX | NKX3-2 |
| GoPubMed | NKX3-2 |
| iHOP | NKX3-2 |
