Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NKX6-1 (NK6 homeobox 1)

Identity

Alias_namesNKX6A
NK homeobox (Drosophila), family 6, A
NK6 transcription factor related, locus 1 (Drosophila)
Alias_symbol (synonym)Nkx6.1
Other aliasNKX6.1
HGNC (Hugo) NKX6-1
LocusID (NCBI) 4825
Atlas_Id 41542
Location 4q21.23  [Link to chromosome band 4q21]
Location_base_pair Starts at 84493283 and ends at 84498234 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NKX6-1   7839
Cards
Entrez_Gene (NCBI)NKX6-1  4825  NK6 homeobox 1
AliasesNKX6.1; NKX6A
GeneCards (Weizmann)NKX6-1
Ensembl hg19 (Hinxton)ENSG00000163623 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163623 [Gene_View]  chr4:84493283-84498234 [Contig_View]  NKX6-1 [Vega]
ICGC DataPortalENSG00000163623
TCGA cBioPortalNKX6-1
AceView (NCBI)NKX6-1
Genatlas (Paris)NKX6-1
WikiGenes4825
SOURCE (Princeton)NKX6-1
Genetics Home Reference (NIH)NKX6-1
Genomic and cartography
GoldenPath hg38 (UCSC)NKX6-1  -     chr4:84493283-84498234 -  4q21.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX6-1  -     4q21.23   [Description]    (hg19-Feb_2009)
EnsemblNKX6-1 - 4q21.23 [CytoView hg19]  NKX6-1 - 4q21.23 [CytoView hg38]
Mapping of homologs : NCBINKX6-1 [Mapview hg19]  NKX6-1 [Mapview hg38]
OMIM602563   
Gene and transcription
Genbank (Entrez)BC160030
RefSeq transcript (Entrez)NM_006168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX6-1
Cluster EST : UnigeneHs.546270 [ NCBI ]
CGAP (NCI)Hs.546270
Alternative Splicing GalleryENSG00000163623
Gene ExpressionNKX6-1 [ NCBI-GEO ]   NKX6-1 [ EBI - ARRAY_EXPRESS ]   NKX6-1 [ SEEK ]   NKX6-1 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX6-1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4825
GTEX Portal (Tissue expression)NKX6-1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78426   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78426  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78426
Splice isoforms : SwissVarP78426
PhosPhoSitePlusP78426
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif    NKX-6.1   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX6-1
DMDM Disease mutations4825
Blocks (Seattle)NKX6-1
SuperfamilyP78426
Human Protein AtlasENSG00000163623
Peptide AtlasP78426
HPRD09092
IPIIPI00019774   IPI01022340   
Protein Interaction databases
DIP (DOE-UCLA)P78426
IntAct (EBI)P78426
FunCoupENSG00000163623
BioGRIDNKX6-1
STRING (EMBL)NKX6-1
ZODIACNKX6-1
Ontologies - Pathways
QuickGOP78426
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  neuron migration  chromatin binding  nucleus  transcription from RNA polymerase II promoter  smoothened signaling pathway  animal organ morphogenesis  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification  regulation of axon extension  pancreas development  positive regulation of insulin secretion  response to nicotine  response to drug  type B pancreatic cell proliferation  positive regulation of neuron differentiation  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  positive regulation of transcription from RNA polymerase II promoter  oligodendrocyte differentiation  positive regulation of sequence-specific DNA binding transcription factor activity  detection of glucose  extracellular exosome  cellular response to cytokine stimulus  cellular response to peptide hormone stimulus  type B pancreatic cell maturation  positive regulation of type B pancreatic cell development  regulation of neuron migration  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  neuron migration  chromatin binding  nucleus  transcription from RNA polymerase II promoter  smoothened signaling pathway  animal organ morphogenesis  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification  regulation of axon extension  pancreas development  positive regulation of insulin secretion  response to nicotine  response to drug  type B pancreatic cell proliferation  positive regulation of neuron differentiation  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  positive regulation of transcription from RNA polymerase II promoter  oligodendrocyte differentiation  positive regulation of sequence-specific DNA binding transcription factor activity  detection of glucose  extracellular exosome  cellular response to cytokine stimulus  cellular response to peptide hormone stimulus  type B pancreatic cell maturation  positive regulation of type B pancreatic cell development  regulation of neuron migration  
Pathways : KEGGMaturity onset diabetes of the young   
NDEx NetworkNKX6-1
Atlas of Cancer Signalling NetworkNKX6-1
Wikipedia pathwaysNKX6-1
Orthology - Evolution
OrthoDB4825
GeneTree (enSembl)ENSG00000163623
Phylogenetic Trees/Animal Genes : TreeFamNKX6-1
HOVERGENP78426
HOGENOMP78426
Homologs : HomoloGeneNKX6-1
Homology/Alignments : Family Browser (UCSC)NKX6-1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX6-1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX6-1
dbVarNKX6-1
ClinVarNKX6-1
1000_GenomesNKX6-1 
Exome Variant ServerNKX6-1
ExAC (Exome Aggregation Consortium)NKX6-1 (select the gene name)
Genetic variants : HAPMAP4825
Genomic Variants (DGV)NKX6-1 [DGVbeta]
DECIPHERNKX6-1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX6-1 
Mutations
ICGC Data PortalNKX6-1 
TCGA Data PortalNKX6-1 
Broad Tumor PortalNKX6-1
OASIS PortalNKX6-1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX6-1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX6-1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX6-1
DgiDB (Drug Gene Interaction Database)NKX6-1
DoCM (Curated mutations)NKX6-1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX6-1 (select a term)
intoGenNKX6-1
Cancer3DNKX6-1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602563   
Orphanet
MedgenNKX6-1
Genetic Testing Registry NKX6-1
NextProtP78426 [Medical]
TSGene4825
GENETestsNKX6-1
Target ValidationNKX6-1
Huge Navigator NKX6-1 [HugePedia]
snp3D : Map Gene to Disease4825
BioCentury BCIQNKX6-1
ClinGenNKX6-1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4825
Chemical/Pharm GKB GenePA31646
Clinical trialNKX6-1
Miscellaneous
canSAR (ICR)NKX6-1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX6-1
EVEXNKX6-1
GoPubMedNKX6-1
iHOPNKX6-1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:22:14 CEST 2017

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