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NKX6-2 (NK6 homeobox 2)

Identity

Alias (NCBI)GTX
NKX6.2
NKX6B
SPAX8
HGNC (Hugo) NKX6-2
HGNC Alias symbNKX6B
GTX
NKX6.1
HGNC Previous nameNK6 transcription factor related, locus 2 (Drosophila)
LocusID (NCBI) 84504
Atlas_Id 70860
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 132783181 and ends at 132786147 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NKX6-2   19321
Cards
Entrez_Gene (NCBI)NKX6-2    NK6 homeobox 2
AliasesGTX; NKX6.2; NKX6B; SPAX8
GeneCards (Weizmann)NKX6-2
Ensembl hg19 (Hinxton)ENSG00000148826 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148826 [Gene_View]  ENSG00000148826 [Sequence]  chr10:132783181-132786147 [Contig_View]  NKX6-2 [Vega]
ICGC DataPortalENSG00000148826
TCGA cBioPortalNKX6-2
AceView (NCBI)NKX6-2
Genatlas (Paris)NKX6-2
SOURCE (Princeton)NKX6-2
Genetics Home Reference (NIH)NKX6-2
Genomic and cartography
GoldenPath hg38 (UCSC)NKX6-2  -     chr10:132783181-132786147 -  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX6-2  -     10q26.3   [Description]    (hg19-Feb_2009)
GoldenPathNKX6-2 - 10q26.3 [CytoView hg19]  NKX6-2 - 10q26.3 [CytoView hg38]
ImmunoBaseENSG00000148826
Genome Data Viewer NCBINKX6-2 [Mapview hg19]  
OMIM605955   617560   
Gene and transcription
Genbank (Entrez)BC101635 BC104823 BF509028
RefSeq transcript (Entrez)NM_177400
Consensus coding sequences : CCDS (NCBI)NKX6-2
Gene ExpressionNKX6-2 [ NCBI-GEO ]   NKX6-2 [ EBI - ARRAY_EXPRESS ]   NKX6-2 [ SEEK ]   NKX6-2 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX6-2 [ Firebrowse - Broad ]
GenevisibleExpression of NKX6-2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84504
GTEX Portal (Tissue expression)NKX6-2
Human Protein AtlasENSG00000148826-NKX6-2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C056   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C056  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C056
PhosPhoSitePlusQ9C056
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX6-2
SuperfamilyQ9C056
AlphaFold pdb e-kbQ9C056   
Human Protein Atlas [tissue]ENSG00000148826-NKX6-2 [tissue]
HPRD09336
Protein Interaction databases
DIP (DOE-UCLA)Q9C056
IntAct (EBI)Q9C056
BioGRIDNKX6-2
STRING (EMBL)NKX6-2
ZODIACNKX6-2
Ontologies - Pathways
QuickGOQ9C056
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  nucleus  nucleus  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  negative regulation of cell fate commitment  positive regulation of cell fate commitment  central nervous system myelination  cell differentiation  endocrine pancreas development  regulation of myelination  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  negative regulation of transcription, DNA-templated  neuromuscular process controlling balance  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  nucleus  nucleus  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  negative regulation of cell fate commitment  positive regulation of cell fate commitment  central nervous system myelination  cell differentiation  endocrine pancreas development  regulation of myelination  negative regulation of glial cell differentiation  positive regulation of glial cell differentiation  negative regulation of transcription, DNA-templated  neuromuscular process controlling balance  sequence-specific double-stranded DNA binding  
NDEx NetworkNKX6-2
Atlas of Cancer Signalling NetworkNKX6-2
Wikipedia pathwaysNKX6-2
Orthology - Evolution
OrthoDB84504
GeneTree (enSembl)ENSG00000148826
Phylogenetic Trees/Animal Genes : TreeFamNKX6-2
Homologs : HomoloGeneNKX6-2
Homology/Alignments : Family Browser (UCSC)NKX6-2
Gene fusions - Rearrangements
Fusion : QuiverNKX6-2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX6-2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX6-2
dbVarNKX6-2
ClinVarNKX6-2
MonarchNKX6-2
1000_GenomesNKX6-2 
Exome Variant ServerNKX6-2
GNOMAD BrowserENSG00000148826
Varsome BrowserNKX6-2
ACMGNKX6-2 variants
VarityQ9C056
Genomic Variants (DGV)NKX6-2 [DGVbeta]
DECIPHERNKX6-2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX6-2 
Mutations
ICGC Data PortalNKX6-2 
TCGA Data PortalNKX6-2 
Broad Tumor PortalNKX6-2
OASIS PortalNKX6-2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX6-2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNKX6-2
Mutations and Diseases : HGMDNKX6-2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNKX6-2
DgiDB (Drug Gene Interaction Database)NKX6-2
DoCM (Curated mutations)NKX6-2
CIViC (Clinical Interpretations of Variants in Cancer)NKX6-2
Cancer3DNKX6-2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605955    617560   
Orphanet
DisGeNETNKX6-2
MedgenNKX6-2
Genetic Testing Registry NKX6-2
NextProtQ9C056 [Medical]
GENETestsNKX6-2
Target ValidationNKX6-2
Huge Navigator NKX6-2 [HugePedia]
ClinGenNKX6-2
Clinical trials, drugs, therapy
MyCancerGenomeNKX6-2
Protein Interactions : CTDNKX6-2
Pharm GKB GenePA134896334
PharosQ9C056
Clinical trialNKX6-2
Miscellaneous
canSAR (ICR)NKX6-2
HarmonizomeNKX6-2
DataMed IndexNKX6-2
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNKX6-2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:48 CEST 2021

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