Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NKX6-3 (NK6 homeobox 3)

Identity

Alias_namesNK6 transcription factor related
Alias_symbol (synonym)FLJ25169
Other aliasNKX6.3
HGNC (Hugo) NKX6-3
LocusID (NCBI) 157848
Atlas_Id 55907
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 41645178 and ends at 41647359 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NKX6-3 (8p11.21) / NKX6-3 (8p11.21)NKX6-3 (8p11.21) / RNF185 (22q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NKX6-3   26328
Cards
Entrez_Gene (NCBI)NKX6-3  157848  NK6 homeobox 3
AliasesNKX6.3
GeneCards (Weizmann)NKX6-3
Ensembl hg19 (Hinxton)ENSG00000165066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165066 [Gene_View]  chr8:41645178-41647359 [Contig_View]  NKX6-3 [Vega]
ICGC DataPortalENSG00000165066
TCGA cBioPortalNKX6-3
AceView (NCBI)NKX6-3
Genatlas (Paris)NKX6-3
WikiGenes157848
SOURCE (Princeton)NKX6-3
Genetics Home Reference (NIH)NKX6-3
Genomic and cartography
GoldenPath hg38 (UCSC)NKX6-3  -     chr8:41645178-41647359 -  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKX6-3  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblNKX6-3 - 8p11.21 [CytoView hg19]  NKX6-3 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBINKX6-3 [Mapview hg19]  NKX6-3 [Mapview hg38]
OMIM610772   
Gene and transcription
Genbank (Entrez)AK057898 BC156229 BC157002
RefSeq transcript (Entrez)NM_152568
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKX6-3
Alternative Splicing GalleryENSG00000165066
Gene ExpressionNKX6-3 [ NCBI-GEO ]   NKX6-3 [ EBI - ARRAY_EXPRESS ]   NKX6-3 [ SEEK ]   NKX6-3 [ MEM ]
Gene Expression Viewer (FireBrowse)NKX6-3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)157848
GTEX Portal (Tissue expression)NKX6-3
Human Protein AtlasENSG00000165066-NKX6-3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NJ46   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NJ46  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NJ46
Splice isoforms : SwissVarA6NJ46
PhosPhoSitePlusA6NJ46
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)NKX6-3
DMDM Disease mutations157848
Blocks (Seattle)NKX6-3
SuperfamilyA6NJ46
Human Protein Atlas [tissue]ENSG00000165066-NKX6-3 [tissue]
Peptide AtlasA6NJ46
HPRD08053
IPIIPI00784472   IPI00065178   
Protein Interaction databases
DIP (DOE-UCLA)A6NJ46
IntAct (EBI)A6NJ46
FunCoupENSG00000165066
BioGRIDNKX6-3
STRING (EMBL)NKX6-3
ZODIACNKX6-3
Ontologies - Pathways
QuickGOA6NJ46
Ontology : AmiGOnucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  sequence-specific DNA binding  
Ontology : EGO-EBInucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  sequence-specific DNA binding  
NDEx NetworkNKX6-3
Atlas of Cancer Signalling NetworkNKX6-3
Wikipedia pathwaysNKX6-3
Orthology - Evolution
OrthoDB157848
GeneTree (enSembl)ENSG00000165066
Phylogenetic Trees/Animal Genes : TreeFamNKX6-3
HOVERGENA6NJ46
HOGENOMA6NJ46
Homologs : HomoloGeneNKX6-3
Homology/Alignments : Family Browser (UCSC)NKX6-3
Gene fusions - Rearrangements
Fusion: Tumor Portal NKX6-3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKX6-3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKX6-3
dbVarNKX6-3
ClinVarNKX6-3
1000_GenomesNKX6-3 
Exome Variant ServerNKX6-3
ExAC (Exome Aggregation Consortium)ENSG00000165066
GNOMAD BrowserENSG00000165066
Genetic variants : HAPMAP157848
Genomic Variants (DGV)NKX6-3 [DGVbeta]
DECIPHERNKX6-3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKX6-3 
Mutations
ICGC Data PortalNKX6-3 
TCGA Data PortalNKX6-3 
Broad Tumor PortalNKX6-3
OASIS PortalNKX6-3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKX6-3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNKX6-3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NKX6-3
DgiDB (Drug Gene Interaction Database)NKX6-3
DoCM (Curated mutations)NKX6-3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKX6-3 (select a term)
intoGenNKX6-3
Cancer3DNKX6-3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610772   
Orphanet
MedgenNKX6-3
Genetic Testing Registry NKX6-3
NextProtA6NJ46 [Medical]
TSGene157848
GENETestsNKX6-3
Target ValidationNKX6-3
Huge Navigator NKX6-3 [HugePedia]
snp3D : Map Gene to Disease157848
BioCentury BCIQNKX6-3
ClinGenNKX6-3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD157848
Chemical/Pharm GKB GenePA145148400
Clinical trialNKX6-3
Miscellaneous
canSAR (ICR)NKX6-3 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKX6-3
EVEXNKX6-3
GoPubMedNKX6-3
iHOPNKX6-3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:02:44 CET 2017

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