NKX6-3 (NK6 homeobox 3)

2016-08-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
NKX6.3
FUSION GENES

Other Information

Locus ID:

NCBI: 157848
MIM: 610772
HGNC: 26328
Ensembl: ENSG00000165066

Variants:

dbSNP: 157848
ClinVar: 157848
TCGA: ENSG00000165066
COSMIC: NKX6-3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165066ENST00000518699A6NJ46
ENSG00000165066ENST00000524115A6NJ46

Expression (GTEx)

0
5
10
15

References

Pubmed IDYearTitleCitations
263149652015NKX6.3 controls gastric differentiation and tumorigenesis.6
273330452016NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.6
267434762016Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.5
285842432017NKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells.2
307100842019Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.2
305149532018Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis.1
306869012019NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.1

Citation

Dessen P

NKX6-3 (NK6 homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55907/nkx6-3