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NLE1 (notchless homolog 1)

Identity

Alias (NCBI)NLE
HGNC (Hugo) NLE1
HGNC Alias symbFLJ10458
HGNC Alias nameNotchless gene homolog, (Drosophila)
HGNC Previous nameNLE
HGNC Previous namenotchless homolog (Drosophila)
LocusID (NCBI) 54475
Atlas_Id 46937
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 35128731 and ends at 35142303 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NF1 (17q11.2) / NLE1 (17q12)NLE1 (17q12) / BAIAP2 (17q25.3)NLE1 (17q12) / FNDC8 (17q12)
NF1 17q11.2 / NLE1 17q12NLE1 17q12 / BAIAP2 17q25.3NLE1 17q12 / FNDC8 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NLE1   19889
Cards
Entrez_Gene (NCBI)NLE1    notchless homolog 1
AliasesNLE
GeneCards (Weizmann)NLE1
Ensembl hg19 (Hinxton)ENSG00000073536 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073536 [Gene_View]  ENSG00000073536 [Sequence]  chr17:35128731-35142303 [Contig_View]  NLE1 [Vega]
ICGC DataPortalENSG00000073536
TCGA cBioPortalNLE1
AceView (NCBI)NLE1
Genatlas (Paris)NLE1
SOURCE (Princeton)NLE1
Genetics Home Reference (NIH)NLE1
Genomic and cartography
GoldenPath hg38 (UCSC)NLE1  -     chr17:35128731-35142303 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLE1  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathNLE1 - 17q12 [CytoView hg19]  NLE1 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000073536
Genome Data Viewer NCBINLE1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB209111 AJ005257 AK001320 AK303253 AK304508
RefSeq transcript (Entrez)NM_001014445 NM_018096
Consensus coding sequences : CCDS (NCBI)NLE1
Gene ExpressionNLE1 [ NCBI-GEO ]   NLE1 [ EBI - ARRAY_EXPRESS ]   NLE1 [ SEEK ]   NLE1 [ MEM ]
Gene Expression Viewer (FireBrowse)NLE1 [ Firebrowse - Broad ]
GenevisibleExpression of NLE1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54475
GTEX Portal (Tissue expression)NLE1
Human Protein AtlasENSG00000073536-NLE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVX2
PhosPhoSitePlusQ9NVX2
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    NLE    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)NLE (PF08154)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08154    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)NLE1
PDB (RSDB)6WAJ   
PDB Europe6WAJ   
PDB (PDBSum)6WAJ   
PDB (IMB)6WAJ   
Structural Biology KnowledgeBase6WAJ   
SCOP (Structural Classification of Proteins)6WAJ   
CATH (Classification of proteins structures)6WAJ   
SuperfamilyQ9NVX2
AlphaFold pdb e-kbQ9NVX2   
Human Protein Atlas [tissue]ENSG00000073536-NLE1 [tissue]
HPRD16903
Protein Interaction databases
DIP (DOE-UCLA)Q9NVX2
IntAct (EBI)Q9NVX2
BioGRIDNLE1
STRING (EMBL)NLE1
ZODIACNLE1
Ontologies - Pathways
QuickGOQ9NVX2
Ontology : AmiGOribosomal large subunit assembly  somitogenesis  kidney development  inner cell mass cell differentiation  nucleoplasm  nucleolus  nucleolus  Notch signaling pathway  negative regulation of mitotic cell cycle  skeletal system morphogenesis  hematopoietic stem cell homeostasis  positive regulation of canonical Wnt signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBIribosomal large subunit assembly  somitogenesis  kidney development  inner cell mass cell differentiation  nucleoplasm  nucleolus  nucleolus  Notch signaling pathway  negative regulation of mitotic cell cycle  skeletal system morphogenesis  hematopoietic stem cell homeostasis  positive regulation of canonical Wnt signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
NDEx NetworkNLE1
Atlas of Cancer Signalling NetworkNLE1
Wikipedia pathwaysNLE1
Orthology - Evolution
OrthoDB54475
GeneTree (enSembl)ENSG00000073536
Phylogenetic Trees/Animal Genes : TreeFamNLE1
Homologs : HomoloGeneNLE1
Homology/Alignments : Family Browser (UCSC)NLE1
Gene fusions - Rearrangements
Fusion : MitelmanNF1/NLE1 [17q11.2/17q12]  
Fusion : MitelmanNLE1/BAIAP2 [17q12/17q25.3]  
Fusion : QuiverNLE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLE1
dbVarNLE1
ClinVarNLE1
MonarchNLE1
1000_GenomesNLE1 
Exome Variant ServerNLE1
GNOMAD BrowserENSG00000073536
Varsome BrowserNLE1
ACMGNLE1 variants
VarityQ9NVX2
Genomic Variants (DGV)NLE1 [DGVbeta]
DECIPHERNLE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLE1 
Mutations
ICGC Data PortalNLE1 
TCGA Data PortalNLE1 
Broad Tumor PortalNLE1
OASIS PortalNLE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLE1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLE1
Mutations and Diseases : HGMDNLE1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNLE1
DgiDB (Drug Gene Interaction Database)NLE1
DoCM (Curated mutations)NLE1
CIViC (Clinical Interpretations of Variants in Cancer)NLE1
Cancer3DNLE1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETNLE1
MedgenNLE1
Genetic Testing Registry NLE1
NextProtQ9NVX2 [Medical]
GENETestsNLE1
Target ValidationNLE1
Huge Navigator NLE1 [HugePedia]
ClinGenNLE1
Clinical trials, drugs, therapy
MyCancerGenomeNLE1
Protein Interactions : CTDNLE1
Pharm GKB GenePA142671263
PharosQ9NVX2
Clinical trialNLE1
Miscellaneous
canSAR (ICR)NLE1
HarmonizomeNLE1
DataMed IndexNLE1
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNLE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:51 CEST 2021

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