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NLE1 (notchless homolog 1 (Drosophila))

Identity

Alias_names(Drosophila)
Alias_symbol (synonym)FLJ10458
Other aliasNle
HGNC (Hugo) NLE1
LocusID (NCBI) 54475
Atlas_Id 46937
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 33458341 and ends at 33469270 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NF1 (17q11.2) / NLE1 (17q12)NLE1 (17q12) / BAIAP2 (17q25.3)NLE1 (17q12) / FNDC8 (17q12)
NF1 17q11.2 / NLE1 17q12NLE1 17q12 / BAIAP2 17q25.3NLE1 17q12 / FNDC8 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLE1   19889
Cards
Entrez_Gene (NCBI)NLE1  54475  notchless homolog 1 (Drosophila)
AliasesNle
GeneCards (Weizmann)NLE1
Ensembl hg19 (Hinxton)ENSG00000073536 [Gene_View]  chr17:33458341-33469270 [Contig_View]  NLE1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000073536 [Gene_View]  chr17:33458341-33469270 [Contig_View]  NLE1 [Vega]
ICGC DataPortalENSG00000073536
TCGA cBioPortalNLE1
AceView (NCBI)NLE1
Genatlas (Paris)NLE1
WikiGenes54475
SOURCE (Princeton)NLE1
Genetics Home Reference (NIH)NLE1
Genomic and cartography
GoldenPath hg19 (UCSC)NLE1  -     chr17:33458341-33469270 -  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NLE1  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblNLE1 - 17q12 [CytoView hg19]  NLE1 - 17q12 [CytoView hg38]
Mapping of homologs : NCBINLE1 [Mapview hg19]  NLE1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB209111 AJ005257 AK001320 AK303253 AK304508
RefSeq transcript (Entrez)NM_001014445 NM_018096
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NLE1
Cluster EST : UnigeneHs.85570 [ NCBI ]
CGAP (NCI)Hs.85570
Alternative Splicing GalleryENSG00000073536
Gene ExpressionNLE1 [ NCBI-GEO ]   NLE1 [ EBI - ARRAY_EXPRESS ]   NLE1 [ SEEK ]   NLE1 [ MEM ]
Gene Expression Viewer (FireBrowse)NLE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54475
GTEX Portal (Tissue expression)NLE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVX2
Splice isoforms : SwissVarQ9NVX2
PhosPhoSitePlusQ9NVX2
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    NLE    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)NLE (PF08154)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08154    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)NLE1
DMDM Disease mutations54475
Blocks (Seattle)NLE1
SuperfamilyQ9NVX2
Human Protein AtlasENSG00000073536
Peptide AtlasQ9NVX2
HPRD16903
IPIIPI00018196   IPI00556116   IPI00939419   IPI00797721   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVX2
IntAct (EBI)Q9NVX2
FunCoupENSG00000073536
BioGRIDNLE1
STRING (EMBL)NLE1
ZODIACNLE1
Ontologies - Pathways
QuickGOQ9NVX2
Ontology : AmiGOsomitogenesis  kidney development  inner cell mass cell differentiation  nucleus  nucleolus  Notch signaling pathway  ribosomal large subunit biogenesis  negative regulation of mitotic cell cycle  skeletal system morphogenesis  hematopoietic stem cell homeostasis  positive regulation of canonical Wnt signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBIsomitogenesis  kidney development  inner cell mass cell differentiation  nucleus  nucleolus  Notch signaling pathway  ribosomal large subunit biogenesis  negative regulation of mitotic cell cycle  skeletal system morphogenesis  hematopoietic stem cell homeostasis  positive regulation of canonical Wnt signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
NDEx NetworkNLE1
Atlas of Cancer Signalling NetworkNLE1
Wikipedia pathwaysNLE1
Orthology - Evolution
OrthoDB54475
GeneTree (enSembl)ENSG00000073536
Phylogenetic Trees/Animal Genes : TreeFamNLE1
HOVERGENQ9NVX2
HOGENOMQ9NVX2
Homologs : HomoloGeneNLE1
Homology/Alignments : Family Browser (UCSC)NLE1
Gene fusions - Rearrangements
Fusion : MitelmanNF1/NLE1 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanNLE1/BAIAP2 [17q12/17q25.3]  [t(17;17)(q12;q25)]  
Fusion: TCGANF1 17q11.2 NLE1 17q12 BRCA
Fusion: TCGANLE1 17q12 BAIAP2 17q25.3 BRCA
Fusion: TCGANLE1 17q12 FNDC8 17q12 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLE1
dbVarNLE1
ClinVarNLE1
1000_GenomesNLE1 
Exome Variant ServerNLE1
ExAC (Exome Aggregation Consortium)NLE1 (select the gene name)
Genetic variants : HAPMAP54475
Genomic Variants (DGV)NLE1 [DGVbeta]
DECIPHER (Syndromes)17:33458341-33469270  ENSG00000073536
CONAN: Copy Number AnalysisNLE1 
Mutations
ICGC Data PortalNLE1 
TCGA Data PortalNLE1 
Broad Tumor PortalNLE1
OASIS PortalNLE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLE1
DgiDB (Drug Gene Interaction Database)NLE1
DoCM (Curated mutations)NLE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLE1 (select a term)
intoGenNLE1
Cancer3DNLE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenNLE1
Genetic Testing Registry NLE1
NextProtQ9NVX2 [Medical]
TSGene54475
GENETestsNLE1
Huge Navigator NLE1 [HugePedia]
snp3D : Map Gene to Disease54475
BioCentury BCIQNLE1
ClinGenNLE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54475
Chemical/Pharm GKB GenePA142671263
Clinical trialNLE1
Miscellaneous
canSAR (ICR)NLE1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLE1
EVEXNLE1
GoPubMedNLE1
iHOPNLE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:18:55 CET 2017

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