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NLGN1 (neuroligin 1)

Identity

Alias_symbol (synonym)KIAA1070
Other aliasNL1
HGNC (Hugo) NLGN1
LocusID (NCBI) 22871
Atlas_Id 41543
Location 3q26.31  [Link to chromosome band 3q26]
Location_base_pair Starts at 173116238 and ends at 174001139 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FNDC3B (3q26.31) / NLGN1 (3q26.31)NAALADL2 (3q26.31) / NLGN1 (3q26.31)NLGN1 (3q26.31) / CCDC155 (19q13.33)
NLGN1 (3q26.31) / KCNC3 (19q13.33)NLGN1 (3q26.31) / NCAM1 (11q23.2)RSRC1 (3q25.32) / NLGN1 (3q26.31)
FNDC3B 3q26.31 / NLGN1 3q26.31NAALADL2 3q26.31 / NLGN1 3q26.31RSRC1 3q25.32 / NLGN1 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLGN1   14291
Cards
Entrez_Gene (NCBI)NLGN1  22871  neuroligin 1
AliasesNL1
GeneCards (Weizmann)NLGN1
Ensembl hg19 (Hinxton)ENSG00000169760 [Gene_View]  chr3:173116238-174001139 [Contig_View]  NLGN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169760 [Gene_View]  chr3:173116238-174001139 [Contig_View]  NLGN1 [Vega]
ICGC DataPortalENSG00000169760
TCGA cBioPortalNLGN1
AceView (NCBI)NLGN1
Genatlas (Paris)NLGN1
WikiGenes22871
SOURCE (Princeton)NLGN1
Genetics Home Reference (NIH)NLGN1
Genomic and cartography
GoldenPath hg19 (UCSC)NLGN1  -     chr3:173116238-174001139 +  3q26.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NLGN1  -     3q26.31   [Description]    (hg38-Dec_2013)
EnsemblNLGN1 - 3q26.31 [CytoView hg19]  NLGN1 - 3q26.31 [CytoView hg38]
Mapping of homologs : NCBINLGN1 [Mapview hg19]  NLGN1 [Mapview hg38]
OMIM600568   
Gene and transcription
Genbank (Entrez)AB028993 AF086015 AK074522 AK129874 AK307813
RefSeq transcript (Entrez)NM_014932
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)NLGN1
Cluster EST : UnigeneHs.732502 [ NCBI ]
CGAP (NCI)Hs.732502
Alternative Splicing GalleryENSG00000169760
Gene ExpressionNLGN1 [ NCBI-GEO ]   NLGN1 [ EBI - ARRAY_EXPRESS ]   NLGN1 [ SEEK ]   NLGN1 [ MEM ]
Gene Expression Viewer (FireBrowse)NLGN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22871
GTEX Portal (Tissue expression)NLGN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2Q7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2Q7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2Q7
Splice isoforms : SwissVarQ8N2Q7
PhosPhoSitePlusQ8N2Q7
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_CS    Nlgn    NLGN1   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)NLGN1
DMDM Disease mutations22871
Blocks (Seattle)NLGN1
SuperfamilyQ8N2Q7
Human Protein AtlasENSG00000169760
Peptide AtlasQ8N2Q7
HPRD07195
IPIIPI00903001   IPI00927327   IPI00926914   IPI00926708   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2Q7
IntAct (EBI)Q8N2Q7
FunCoupENSG00000169760
BioGRIDNLGN1
STRING (EMBL)NLGN1
ZODIACNLGN1
Ontologies - Pathways
QuickGOQ8N2Q7
Ontology : AmiGOregulation of respiratory gaseous exchange by neurological system process  receptor activity  receptor activity  extracellular space  Golgi apparatus  cytosol  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein targeting  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  neuron cell-cell adhesion  neuron cell-cell adhesion  nervous system development  synapse assembly  external side of plasma membrane  cell surface  cell surface  positive regulation of circadian sleep/wake cycle, wakefulness  postsynaptic density  synaptic vesicle targeting  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  NMDA selective glutamate receptor complex  neuronal signal transduction  cell junction  PDZ domain binding  dendrite  neuron projection development  positive regulation of synaptic transmission, GABAergic  filopodium tip  protein localization to synapse  neurexin family protein binding  neurexin family protein binding  dendritic spine  dendritic shaft  establishment of protein localization  synapse  postsynaptic membrane  regulation of neuron differentiation  protein dimerization activity  rhythmic process  cytoskeletal matrix organization at active zone  cell adhesion molecule binding  protein homooligomerization  protein heterotetramerization  positive regulation of filopodium assembly  positive regulation of synapse assembly  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  long-term synaptic potentiation  positive regulation of dendritic spine development  positive regulation of dendritic spine development  negative regulation of dendritic spine morphogenesis  terminal button organization  synaptic vesicle clustering  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  AMPA glutamate receptor clustering  NMDA glutamate receptor clustering  neurexin clustering involved in presynaptic membrane assembly  postsynaptic density protein 95 clustering  receptor localization to synapse  neuronal postsynaptic density  presynapse  presynapse  positive regulation of ruffle assembly  positive regulation of synaptic vesicle endocytosis  positive regulation of protein localization to synapse  positive regulation of intracellular signal transduction  positive regulation of synaptic vesicle exocytosis  regulation of N-methyl-D-aspartate selective glutamate receptor activity  regulation of N-methyl-D-aspartate selective glutamate receptor activity  regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  
Ontology : EGO-EBIregulation of respiratory gaseous exchange by neurological system process  receptor activity  receptor activity  extracellular space  Golgi apparatus  cytosol  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein targeting  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  neuron cell-cell adhesion  neuron cell-cell adhesion  nervous system development  synapse assembly  external side of plasma membrane  cell surface  cell surface  positive regulation of circadian sleep/wake cycle, wakefulness  postsynaptic density  synaptic vesicle targeting  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  NMDA selective glutamate receptor complex  neuronal signal transduction  cell junction  PDZ domain binding  dendrite  neuron projection development  positive regulation of synaptic transmission, GABAergic  filopodium tip  protein localization to synapse  neurexin family protein binding  neurexin family protein binding  dendritic spine  dendritic shaft  establishment of protein localization  synapse  postsynaptic membrane  regulation of neuron differentiation  protein dimerization activity  rhythmic process  cytoskeletal matrix organization at active zone  cell adhesion molecule binding  protein homooligomerization  protein heterotetramerization  positive regulation of filopodium assembly  positive regulation of synapse assembly  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  long-term synaptic potentiation  positive regulation of dendritic spine development  positive regulation of dendritic spine development  negative regulation of dendritic spine morphogenesis  terminal button organization  synaptic vesicle clustering  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  AMPA glutamate receptor clustering  NMDA glutamate receptor clustering  neurexin clustering involved in presynaptic membrane assembly  postsynaptic density protein 95 clustering  receptor localization to synapse  neuronal postsynaptic density  presynapse  presynapse  positive regulation of ruffle assembly  positive regulation of synaptic vesicle endocytosis  positive regulation of protein localization to synapse  positive regulation of intracellular signal transduction  positive regulation of synaptic vesicle exocytosis  regulation of N-methyl-D-aspartate selective glutamate receptor activity  regulation of N-methyl-D-aspartate selective glutamate receptor activity  regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNLGN1
Atlas of Cancer Signalling NetworkNLGN1
Wikipedia pathwaysNLGN1
Orthology - Evolution
OrthoDB22871
GeneTree (enSembl)ENSG00000169760
Phylogenetic Trees/Animal Genes : TreeFamNLGN1
HOVERGENQ8N2Q7
HOGENOMQ8N2Q7
Homologs : HomoloGeneNLGN1
Homology/Alignments : Family Browser (UCSC)NLGN1
Gene fusions - Rearrangements
Fusion : MitelmanFNDC3B/NLGN1 [3q26.31/3q26.31]  [t(3;3)(q26;q26)]  
Fusion : MitelmanNAALADL2/NLGN1 [3q26.31/3q26.31]  [t(3;3)(q26;q26)]  
Fusion : MitelmanNLGN1/CCDC155 [3q26.31/19q13.33]  [t(3;19)(q26;q13)]  
Fusion : MitelmanRSRC1/NLGN1 [3q25.32/3q26.31]  [t(3;3)(q25;q26)]  
Fusion: TCGAFNDC3B 3q26.31 NLGN1 3q26.31 BRCA
Fusion: TCGANAALADL2 3q26.31 NLGN1 3q26.31 BRCA
Fusion: TCGARSRC1 3q25.32 NLGN1 3q26.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLGN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLGN1
dbVarNLGN1
ClinVarNLGN1
1000_GenomesNLGN1 
Exome Variant ServerNLGN1
ExAC (Exome Aggregation Consortium)NLGN1 (select the gene name)
Genetic variants : HAPMAP22871
Genomic Variants (DGV)NLGN1 [DGVbeta]
DECIPHER (Syndromes)3:173116238-174001139  ENSG00000169760
CONAN: Copy Number AnalysisNLGN1 
Mutations
ICGC Data PortalNLGN1 
TCGA Data PortalNLGN1 
Broad Tumor PortalNLGN1
OASIS PortalNLGN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLGN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLGN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLGN1
DgiDB (Drug Gene Interaction Database)NLGN1
DoCM (Curated mutations)NLGN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLGN1 (select a term)
intoGenNLGN1
Cancer3DNLGN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600568   
Orphanet
MedgenNLGN1
Genetic Testing Registry NLGN1
NextProtQ8N2Q7 [Medical]
TSGene22871
GENETestsNLGN1
Huge Navigator NLGN1 [HugePedia]
snp3D : Map Gene to Disease22871
BioCentury BCIQNLGN1
ClinGenNLGN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22871
Chemical/Pharm GKB GenePA31647
Clinical trialNLGN1
Miscellaneous
canSAR (ICR)NLGN1 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLGN1
EVEXNLGN1
GoPubMedNLGN1
iHOPNLGN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:18:55 CET 2017

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