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NLGN2 (neuroligin 2)

Identity

Alias_symbol (synonym)KIAA1366
Other alias-
HGNC (Hugo) NLGN2
LocusID (NCBI) 57555
Atlas_Id 70863
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7408183 and ends at 7419864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NLGN2 (17p13.1) / NLGN2 (17p13.1)PLCB1 (20p12.3) / NLGN2 (17p13.1)ULK1 (12q24.33) / NLGN2 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLGN2   14290
Cards
Entrez_Gene (NCBI)NLGN2  57555  neuroligin 2
Aliases
GeneCards (Weizmann)NLGN2
Ensembl hg19 (Hinxton)ENSG00000169992 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169992 [Gene_View]  chr17:7408183-7419864 [Contig_View]  NLGN2 [Vega]
ICGC DataPortalENSG00000169992
TCGA cBioPortalNLGN2
AceView (NCBI)NLGN2
Genatlas (Paris)NLGN2
WikiGenes57555
SOURCE (Princeton)NLGN2
Genetics Home Reference (NIH)NLGN2
Genomic and cartography
GoldenPath hg38 (UCSC)NLGN2  -     chr17:7408183-7419864 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLGN2  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblNLGN2 - 17p13.1 [CytoView hg19]  NLGN2 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBINLGN2 [Mapview hg19]  NLGN2 [Mapview hg38]
OMIM606479   
Gene and transcription
Genbank (Entrez)AA447769 AB037787 AF376802 AI613237 BC069217
RefSeq transcript (Entrez)NM_020795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLGN2
Cluster EST : UnigeneHs.26229 [ NCBI ]
CGAP (NCI)Hs.26229
Alternative Splicing GalleryENSG00000169992
Gene ExpressionNLGN2 [ NCBI-GEO ]   NLGN2 [ EBI - ARRAY_EXPRESS ]   NLGN2 [ SEEK ]   NLGN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NLGN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57555
GTEX Portal (Tissue expression)NLGN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ4
Splice isoforms : SwissVarQ8NFZ4
PhosPhoSitePlusQ8NFZ4
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_CS    Nlgn    NLGN2   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)NLGN2
DMDM Disease mutations57555
Blocks (Seattle)NLGN2
SuperfamilyQ8NFZ4
Human Protein AtlasENSG00000169992
Peptide AtlasQ8NFZ4
HPRD07348
IPIIPI00176424   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ4
IntAct (EBI)Q8NFZ4
FunCoupENSG00000169992
BioGRIDNLGN2
STRING (EMBL)NLGN2
ZODIACNLGN2
Ontologies - Pathways
QuickGOQ8NFZ4
Ontology : AmiGOregulation of respiratory gaseous exchange by neurological system process  receptor activity  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neuron cell-cell adhesion  synapse assembly  synapse assembly  synapse assembly  cell surface  cell surface  membrane  single organismal cell-cell adhesion  sensory perception of pain  cell junction  positive regulation of insulin secretion  positive regulation of synaptic transmission, GABAergic  protein localization to synapse  locomotory exploration behavior  neurexin family protein binding  neurexin family protein binding  neurexin family protein binding  presynaptic membrane  synapse  synapse  postsynaptic membrane  cell-cell junction maintenance  modulation of synaptic transmission  modulation of synaptic transmission  synapse organization  cell adhesion molecule binding  neuromuscular process controlling balance  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  inhibitory synapse  terminal button organization  postsynaptic membrane assembly  presynaptic membrane assembly  gephyrin clustering involved in postsynaptic density assembly  postsynaptic density protein 95 clustering  positive regulation of inhibitory postsynaptic potential  integral component of postsynaptic membrane  positive regulation of protein localization to synapse  inhibitory synapse assembly  regulation of AMPA receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  
Ontology : EGO-EBIregulation of respiratory gaseous exchange by neurological system process  receptor activity  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neuron cell-cell adhesion  synapse assembly  synapse assembly  synapse assembly  cell surface  cell surface  membrane  single organismal cell-cell adhesion  sensory perception of pain  cell junction  positive regulation of insulin secretion  positive regulation of synaptic transmission, GABAergic  protein localization to synapse  locomotory exploration behavior  neurexin family protein binding  neurexin family protein binding  neurexin family protein binding  presynaptic membrane  synapse  synapse  postsynaptic membrane  cell-cell junction maintenance  modulation of synaptic transmission  modulation of synaptic transmission  synapse organization  cell adhesion molecule binding  neuromuscular process controlling balance  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  inhibitory synapse  terminal button organization  postsynaptic membrane assembly  presynaptic membrane assembly  gephyrin clustering involved in postsynaptic density assembly  postsynaptic density protein 95 clustering  positive regulation of inhibitory postsynaptic potential  integral component of postsynaptic membrane  positive regulation of protein localization to synapse  inhibitory synapse assembly  regulation of AMPA receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNLGN2
Atlas of Cancer Signalling NetworkNLGN2
Wikipedia pathwaysNLGN2
Orthology - Evolution
OrthoDB57555
GeneTree (enSembl)ENSG00000169992
Phylogenetic Trees/Animal Genes : TreeFamNLGN2
HOVERGENQ8NFZ4
HOGENOMQ8NFZ4
Homologs : HomoloGeneNLGN2
Homology/Alignments : Family Browser (UCSC)NLGN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLGN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLGN2
dbVarNLGN2
ClinVarNLGN2
1000_GenomesNLGN2 
Exome Variant ServerNLGN2
ExAC (Exome Aggregation Consortium)NLGN2 (select the gene name)
Genetic variants : HAPMAP57555
Genomic Variants (DGV)NLGN2 [DGVbeta]
DECIPHERNLGN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLGN2 
Mutations
ICGC Data PortalNLGN2 
TCGA Data PortalNLGN2 
Broad Tumor PortalNLGN2
OASIS PortalNLGN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLGN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLGN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLGN2
DgiDB (Drug Gene Interaction Database)NLGN2
DoCM (Curated mutations)NLGN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLGN2 (select a term)
intoGenNLGN2
Cancer3DNLGN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606479   
Orphanet
MedgenNLGN2
Genetic Testing Registry NLGN2
NextProtQ8NFZ4 [Medical]
TSGene57555
GENETestsNLGN2
Target ValidationNLGN2
Huge Navigator NLGN2 [HugePedia]
snp3D : Map Gene to Disease57555
BioCentury BCIQNLGN2
ClinGenNLGN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57555
Chemical/Pharm GKB GenePA31648
Clinical trialNLGN2
Miscellaneous
canSAR (ICR)NLGN2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLGN2
EVEXNLGN2
GoPubMedNLGN2
iHOPNLGN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:45 CEST 2017

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