Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NLGN3 (neuroligin 3)

Identity

Alias_symbol (synonym)HNL3
KIAA1480
ASPGX1
AUTSX1
Other alias
HGNC (Hugo) NLGN3
LocusID (NCBI) 54413
Atlas_Id 55751
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 71144831 and ends at 71171201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NLGN3 (Xq13.1) / NLGN3 (Xq13.1)NLGN3 (Xq13.1) / TNKS1BP1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLGN3   14289
Cards
Entrez_Gene (NCBI)NLGN3  54413  neuroligin 3
AliasesHNL3
GeneCards (Weizmann)NLGN3
Ensembl hg19 (Hinxton)ENSG00000196338 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196338 [Gene_View]  chrX:71144831-71171201 [Contig_View]  NLGN3 [Vega]
ICGC DataPortalENSG00000196338
TCGA cBioPortalNLGN3
AceView (NCBI)NLGN3
Genatlas (Paris)NLGN3
WikiGenes54413
SOURCE (Princeton)NLGN3
Genetics Home Reference (NIH)NLGN3
Genomic and cartography
GoldenPath hg38 (UCSC)NLGN3  -     chrX:71144831-71171201 +  Xq13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLGN3  -     Xq13.1   [Description]    (hg19-Feb_2009)
EnsemblNLGN3 - Xq13.1 [CytoView hg19]  NLGN3 - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBINLGN3 [Mapview hg19]  NLGN3 [Mapview hg38]
OMIM300336   300425   300494   
Gene and transcription
Genbank (Entrez)AB040913 AF217411 AF217412 AK074814 AK296217
RefSeq transcript (Entrez)NM_001166660 NM_001321276 NM_018977 NM_181303
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLGN3
Cluster EST : UnigeneHs.438877 [ NCBI ]
CGAP (NCI)Hs.438877
Alternative Splicing GalleryENSG00000196338
Gene ExpressionNLGN3 [ NCBI-GEO ]   NLGN3 [ EBI - ARRAY_EXPRESS ]   NLGN3 [ SEEK ]   NLGN3 [ MEM ]
Gene Expression Viewer (FireBrowse)NLGN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54413
GTEX Portal (Tissue expression)NLGN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZ94   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZ94  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZ94
Splice isoforms : SwissVarQ9NZ94
PhosPhoSitePlusQ9NZ94
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_CS    Nlgn    NLGN3   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)NLGN3
DMDM Disease mutations54413
Blocks (Seattle)NLGN3
SuperfamilyQ9NZ94
Human Protein AtlasENSG00000196338
Peptide AtlasQ9NZ94
HPRD02275
IPIIPI00002307   IPI00184861   IPI00425941   IPI00644794   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZ94
IntAct (EBI)Q9NZ94
FunCoupENSG00000196338
BioGRIDNLGN3
STRING (EMBL)NLGN3
ZODIACNLGN3
Ontologies - Pathways
QuickGOQ9NZ94
Ontology : AmiGOregulation of respiratory gaseous exchange by neurological system process  receptor activity  receptor activity  protein binding  plasma membrane  integral component of plasma membrane  receptor-mediated endocytosis  neuron cell-cell adhesion  neuron cell-cell adhesion  synapse assembly  synapse assembly  learning  visual learning  cell surface  cell junction  endocytic vesicle  adult behavior  social behavior  neurexin family protein binding  neurexin family protein binding  synapse  axon extension  oligodendrocyte differentiation  modulation of synaptic transmission  modulation of synaptic transmission  synapse organization  cell adhesion molecule binding  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  rhythmic synaptic transmission  excitatory synapse  excitatory postsynaptic potential  inhibitory postsynaptic potential  long-term synaptic potentiation  negative regulation of dendritic spine morphogenesis  vocalization behavior  negative regulation of excitatory postsynaptic potential  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  integral component of postsynaptic membrane  regulation of long-term synaptic potentiation  regulation of NMDA receptor activity  regulation of terminal button organization  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  positive regulation of AMPA receptor activity  
Ontology : EGO-EBIregulation of respiratory gaseous exchange by neurological system process  receptor activity  receptor activity  protein binding  plasma membrane  integral component of plasma membrane  receptor-mediated endocytosis  neuron cell-cell adhesion  neuron cell-cell adhesion  synapse assembly  synapse assembly  learning  visual learning  cell surface  cell junction  endocytic vesicle  adult behavior  social behavior  neurexin family protein binding  neurexin family protein binding  synapse  axon extension  oligodendrocyte differentiation  modulation of synaptic transmission  modulation of synaptic transmission  synapse organization  cell adhesion molecule binding  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  carboxylic ester hydrolase activity  rhythmic synaptic transmission  excitatory synapse  excitatory postsynaptic potential  inhibitory postsynaptic potential  long-term synaptic potentiation  negative regulation of dendritic spine morphogenesis  vocalization behavior  negative regulation of excitatory postsynaptic potential  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  integral component of postsynaptic membrane  regulation of long-term synaptic potentiation  regulation of NMDA receptor activity  regulation of terminal button organization  positive regulation of excitatory postsynaptic potential  positive regulation of synaptic vesicle clustering  positive regulation of AMPA receptor activity  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNLGN3
Atlas of Cancer Signalling NetworkNLGN3
Wikipedia pathwaysNLGN3
Orthology - Evolution
OrthoDB54413
GeneTree (enSembl)ENSG00000196338
Phylogenetic Trees/Animal Genes : TreeFamNLGN3
HOVERGENQ9NZ94
HOGENOMQ9NZ94
Homologs : HomoloGeneNLGN3
Homology/Alignments : Family Browser (UCSC)NLGN3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLGN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLGN3
dbVarNLGN3
ClinVarNLGN3
1000_GenomesNLGN3 
Exome Variant ServerNLGN3
ExAC (Exome Aggregation Consortium)NLGN3 (select the gene name)
Genetic variants : HAPMAP54413
Genomic Variants (DGV)NLGN3 [DGVbeta]
DECIPHERNLGN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLGN3 
Mutations
ICGC Data PortalNLGN3 
TCGA Data PortalNLGN3 
Broad Tumor PortalNLGN3
OASIS PortalNLGN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLGN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLGN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch NLGN3
DgiDB (Drug Gene Interaction Database)NLGN3
DoCM (Curated mutations)NLGN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLGN3 (select a term)
intoGenNLGN3
Cancer3DNLGN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300336    300425    300494   
Orphanet
MedgenNLGN3
Genetic Testing Registry NLGN3
NextProtQ9NZ94 [Medical]
TSGene54413
GENETestsNLGN3
Target ValidationNLGN3
Huge Navigator NLGN3 [HugePedia]
snp3D : Map Gene to Disease54413
BioCentury BCIQNLGN3
ClinGenNLGN3 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54413
Chemical/Pharm GKB GenePA31649
Clinical trialNLGN3
Miscellaneous
canSAR (ICR)NLGN3 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLGN3
EVEXNLGN3
GoPubMedNLGN3
iHOPNLGN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:46:56 CEST 2017

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