Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NLGN4X (neuroligin 4, X-linked)

Identity

Alias_namesNLGN4
neuroligin 4
Alias_symbol (synonym)KIAA1260
NLGN
HLNX
Other aliasASPGX2
AUTSX2
HNL4X
HGNC (Hugo) NLGN4X
LocusID (NCBI) 57502
Atlas_Id 55987
Location Xp22.32  [Link to chromosome band Xp22]
Location_base_pair Starts at 5890026 and ends at 6228882 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NLGN4X (Xp22.32) / RPS23 (5q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLGN4X   14287
Cards
Entrez_Gene (NCBI)NLGN4X  57502  neuroligin 4, X-linked
AliasesASPGX2; AUTSX2; HLNX; HNL4X; 
NLGN4
GeneCards (Weizmann)NLGN4X
Ensembl hg19 (Hinxton)ENSG00000146938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146938 [Gene_View]  chrX:5890026-6228882 [Contig_View]  NLGN4X [Vega]
ICGC DataPortalENSG00000146938
TCGA cBioPortalNLGN4X
AceView (NCBI)NLGN4X
Genatlas (Paris)NLGN4X
WikiGenes57502
SOURCE (Princeton)NLGN4X
Genetics Home Reference (NIH)NLGN4X
Genomic and cartography
GoldenPath hg38 (UCSC)NLGN4X  -     chrX:5890026-6228882 -  Xp22.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLGN4X  -     Xp22.32   [Description]    (hg19-Feb_2009)
EnsemblNLGN4X - Xp22.32 [CytoView hg19]  NLGN4X - Xp22.32 [CytoView hg38]
Mapping of homologs : NCBINLGN4X [Mapview hg19]  NLGN4X [Mapview hg38]
OMIM300427   300495   300497   
Gene and transcription
Genbank (Entrez)AB033086 AF376803 AK022621 AK055471 AK291036
RefSeq transcript (Entrez)NM_001282145 NM_001282146 NM_020742 NM_181332
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLGN4X
Cluster EST : UnigeneHs.21107 [ NCBI ]
CGAP (NCI)Hs.21107
Alternative Splicing GalleryENSG00000146938
Gene ExpressionNLGN4X [ NCBI-GEO ]   NLGN4X [ EBI - ARRAY_EXPRESS ]   NLGN4X [ SEEK ]   NLGN4X [ MEM ]
Gene Expression Viewer (FireBrowse)NLGN4X [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57502
GTEX Portal (Tissue expression)NLGN4X
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N0W4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N0W4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N0W4
Splice isoforms : SwissVarQ8N0W4
PhosPhoSitePlusQ8N0W4
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_CS    Nlgn    NLGN4   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)NLGN4X
DMDM Disease mutations57502
Blocks (Seattle)NLGN4X
PDB (SRS)2WQZ    2XB6    3BE8   
PDB (PDBSum)2WQZ    2XB6    3BE8   
PDB (IMB)2WQZ    2XB6    3BE8   
PDB (RSDB)2WQZ    2XB6    3BE8   
Structural Biology KnowledgeBase2WQZ    2XB6    3BE8   
SCOP (Structural Classification of Proteins)2WQZ    2XB6    3BE8   
CATH (Classification of proteins structures)2WQZ    2XB6    3BE8   
SuperfamilyQ8N0W4
Human Protein AtlasENSG00000146938
Peptide AtlasQ8N0W4
HPRD02336
IPIIPI00643159   
Protein Interaction databases
DIP (DOE-UCLA)Q8N0W4
IntAct (EBI)Q8N0W4
FunCoupENSG00000146938
BioGRIDNLGN4X
STRING (EMBL)NLGN4X
ZODIACNLGN4X
Ontologies - Pathways
QuickGOQ8N0W4
Ontology : AmiGObrainstem development  receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  learning  cell surface  postsynaptic density  integral component of membrane  cerebellum development  cell junction  neuron differentiation  dendrite  adult behavior  chloride ion binding  social behavior  organ growth  neurexin family protein binding  neurexin family protein binding  protein homodimerization activity  synapse  postsynaptic membrane  cell-cell junction organization  synapse organization  synapse organization  cell adhesion molecule binding  carboxylic ester hydrolase activity  excitatory synapse  vocalization behavior  vocalization behavior  negative regulation of excitatory postsynaptic potential  presynaptic membrane assembly  scaffold protein binding  
Ontology : EGO-EBIbrainstem development  receptor activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  learning  cell surface  postsynaptic density  integral component of membrane  cerebellum development  cell junction  neuron differentiation  dendrite  adult behavior  chloride ion binding  social behavior  organ growth  neurexin family protein binding  neurexin family protein binding  protein homodimerization activity  synapse  postsynaptic membrane  cell-cell junction organization  synapse organization  synapse organization  cell adhesion molecule binding  carboxylic ester hydrolase activity  excitatory synapse  vocalization behavior  vocalization behavior  negative regulation of excitatory postsynaptic potential  presynaptic membrane assembly  scaffold protein binding  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNLGN4X
Atlas of Cancer Signalling NetworkNLGN4X
Wikipedia pathwaysNLGN4X
Orthology - Evolution
OrthoDB57502
GeneTree (enSembl)ENSG00000146938
Phylogenetic Trees/Animal Genes : TreeFamNLGN4X
HOVERGENQ8N0W4
HOGENOMQ8N0W4
Homologs : HomoloGeneNLGN4X
Homology/Alignments : Family Browser (UCSC)NLGN4X
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLGN4X [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLGN4X
dbVarNLGN4X
ClinVarNLGN4X
1000_GenomesNLGN4X 
Exome Variant ServerNLGN4X
ExAC (Exome Aggregation Consortium)NLGN4X (select the gene name)
Genetic variants : HAPMAP57502
Genomic Variants (DGV)NLGN4X [DGVbeta]
DECIPHERNLGN4X [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLGN4X 
Mutations
ICGC Data PortalNLGN4X 
TCGA Data PortalNLGN4X 
Broad Tumor PortalNLGN4X
OASIS PortalNLGN4X [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLGN4X  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLGN4X
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch NLGN4X
DgiDB (Drug Gene Interaction Database)NLGN4X
DoCM (Curated mutations)NLGN4X (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLGN4X (select a term)
intoGenNLGN4X
Cancer3DNLGN4X(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300427    300495    300497   
Orphanet
MedgenNLGN4X
Genetic Testing Registry NLGN4X
NextProtQ8N0W4 [Medical]
TSGene57502
GENETestsNLGN4X
Target ValidationNLGN4X
Huge Navigator NLGN4X [HugePedia]
snp3D : Map Gene to Disease57502
BioCentury BCIQNLGN4X
ClinGenNLGN4X
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57502
Chemical/Pharm GKB GenePA31650
Clinical trialNLGN4X
Miscellaneous
canSAR (ICR)NLGN4X (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLGN4X
EVEXNLGN4X
GoPubMedNLGN4X
iHOPNLGN4X
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:22:15 CEST 2017

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