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NLGN4Y (neuroligin 4 Y-linked)

Identity

Other aliasHNL4Y
HGNC (Hugo) NLGN4Y
LocusID (NCBI) 22829
Atlas_Id 57485
Location Yq11.221  [Link to chromosome band Yq11]
Location_base_pair Starts at 14523746 and ends at 14843968 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NLGN4Y (Yq11.221) / TXLNGY (Yq11.222)RUNX1 (21q22.12) / NLGN4Y (Yq11.221)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  NLGN4Y/TXLNGY (Yq11)


External links

Nomenclature
HGNC (Hugo)NLGN4Y   15529
Cards
Entrez_Gene (NCBI)NLGN4Y  22829  neuroligin 4 Y-linked
AliasesHNL4Y
GeneCards (Weizmann)NLGN4Y
Ensembl hg19 (Hinxton)ENSG00000165246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165246 [Gene_View]  ENSG00000165246 [Sequence]  chrY:14523746-14843968 [Contig_View]  NLGN4Y [Vega]
ICGC DataPortalENSG00000165246
TCGA cBioPortalNLGN4Y
AceView (NCBI)NLGN4Y
Genatlas (Paris)NLGN4Y
WikiGenes22829
SOURCE (Princeton)NLGN4Y
Genetics Home Reference (NIH)NLGN4Y
Genomic and cartography
GoldenPath hg38 (UCSC)NLGN4Y  -     chrY:14523746-14843968 +  Yq11.221   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLGN4Y  -     Yq11.221   [Description]    (hg19-Feb_2009)
EnsemblNLGN4Y - Yq11.221 [CytoView hg19]  NLGN4Y - Yq11.221 [CytoView hg38]
Mapping of homologs : NCBINLGN4Y [Mapview hg19]  NLGN4Y [Mapview hg38]
OMIM400028   
Gene and transcription
Genbank (Entrez)AA558153 AB023168 AF376804 AK295117 AX773941
RefSeq transcript (Entrez)NM_001164238 NM_001206850 NM_001365584 NM_001365586 NM_001365588 NM_001365590 NM_001365591 NM_001365592 NM_001365593 NM_014893
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLGN4Y
Cluster EST : UnigeneHs.694600 [ NCBI ]
CGAP (NCI)Hs.694600
Alternative Splicing GalleryENSG00000165246
Gene ExpressionNLGN4Y [ NCBI-GEO ]   NLGN4Y [ EBI - ARRAY_EXPRESS ]   NLGN4Y [ SEEK ]   NLGN4Y [ MEM ]
Gene Expression Viewer (FireBrowse)NLGN4Y [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22829
GTEX Portal (Tissue expression)NLGN4Y
Human Protein AtlasENSG00000165246-NLGN4Y [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ3
Splice isoforms : SwissVarQ8NFZ3
PhosPhoSitePlusQ8NFZ3
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_CS    Nlgn    NLGN4   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)NLGN4Y
DMDM Disease mutations22829
Blocks (Seattle)NLGN4Y
SuperfamilyQ8NFZ3
Human Protein Atlas [tissue]ENSG00000165246-NLGN4Y [tissue]
Peptide AtlasQ8NFZ3
IPIIPI00171705   IPI00240784   IPI00374695   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ3
IntAct (EBI)Q8NFZ3
FunCoupENSG00000165246
BioGRIDNLGN4Y
STRING (EMBL)NLGN4Y
ZODIACNLGN4Y
Ontologies - Pathways
QuickGOQ8NFZ3
Ontology : AmiGOprotein binding  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neuron cell-cell adhesion  learning  cell surface  postsynaptic density  cell junction  social behavior  signaling receptor activity  neurexin family protein binding  synapse  postsynaptic membrane  synaptic vesicle endocytosis  modulation of chemical synaptic transmission  cell adhesion molecule binding  vocalization behavior  spanning component of membrane  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  presynapse  symmetric, GABA-ergic, inhibitory synapse  asymmetric, glutamatergic, excitatory synapse  presynapse assembly  
Ontology : EGO-EBIprotein binding  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neuron cell-cell adhesion  learning  cell surface  postsynaptic density  cell junction  social behavior  signaling receptor activity  neurexin family protein binding  synapse  postsynaptic membrane  synaptic vesicle endocytosis  modulation of chemical synaptic transmission  cell adhesion molecule binding  vocalization behavior  spanning component of membrane  postsynaptic membrane assembly  presynaptic membrane assembly  scaffold protein binding  presynapse  symmetric, GABA-ergic, inhibitory synapse  asymmetric, glutamatergic, excitatory synapse  presynapse assembly  
NDEx NetworkNLGN4Y
Atlas of Cancer Signalling NetworkNLGN4Y
Wikipedia pathwaysNLGN4Y
Orthology - Evolution
OrthoDB22829
GeneTree (enSembl)ENSG00000165246
Phylogenetic Trees/Animal Genes : TreeFamNLGN4Y
HOVERGENQ8NFZ3
HOGENOMQ8NFZ3
Homologs : HomoloGeneNLGN4Y
Homology/Alignments : Family Browser (UCSC)NLGN4Y
Gene fusions - Rearrangements
Fusion : QuiverNLGN4Y
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLGN4Y [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLGN4Y
dbVarNLGN4Y
ClinVarNLGN4Y
1000_GenomesNLGN4Y 
Exome Variant ServerNLGN4Y
ExAC (Exome Aggregation Consortium)ENSG00000165246
GNOMAD BrowserENSG00000165246
Varsome BrowserNLGN4Y
Genetic variants : HAPMAP22829
Genomic Variants (DGV)NLGN4Y [DGVbeta]
DECIPHERNLGN4Y [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLGN4Y 
Mutations
ICGC Data PortalNLGN4Y 
TCGA Data PortalNLGN4Y 
Broad Tumor PortalNLGN4Y
OASIS PortalNLGN4Y [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLGN4Y  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLGN4Y
BioMutasearch NLGN4Y
DgiDB (Drug Gene Interaction Database)NLGN4Y
DoCM (Curated mutations)NLGN4Y (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLGN4Y (select a term)
intoGenNLGN4Y
Cancer3DNLGN4Y(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM400028   
Orphanet
DisGeNETNLGN4Y
MedgenNLGN4Y
Genetic Testing Registry NLGN4Y
NextProtQ8NFZ3 [Medical]
TSGene22829
GENETestsNLGN4Y
Target ValidationNLGN4Y
Huge Navigator NLGN4Y [HugePedia]
snp3D : Map Gene to Disease22829
BioCentury BCIQNLGN4Y
ClinGenNLGN4Y
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22829
Chemical/Pharm GKB GenePA38386
Clinical trialNLGN4Y
Miscellaneous
canSAR (ICR)NLGN4Y (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLGN4Y
EVEXNLGN4Y
GoPubMedNLGN4Y
iHOPNLGN4Y
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:26:21 CET 2018

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