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NLK (nemo like kinase)

Identity

Alias (NCBI)-
HGNC (Hugo) NLK
HGNC Previous namenemo-like kinase
LocusID (NCBI) 51701
Atlas_Id 43380
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28042677 and ends at 28196378 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KHDC1 (6q13) / NLK (17q11.2)NLK (17q11.2) / BCAS3 (17q23.2)NLK (17q11.2) / DUSP14 (17q12)
NLK (17q11.2) / KALRN (3q21.2)NLK (17q11.2) / NF1 (17q11.2)NLK (17q11.2) / NLK (17q11.2)
NLK (17q11.2) / PPP1R1B (17q12)NLK (17q11.2) / RAD51D (17q12)TADA2A (17q12) / NLK (17q11.2)
USP32 (17q23.1) / NLK (17q11.2)WRB (21q22.2) / NLK (17q11.2)KHDC1 6q13 / NLK 17q11.2
NLK 17q11.2 / BCAS3 17q23.2NLK 17q11.2 / DUSP14 17q12NLK 17q11.2 / KALRN 3q21.2
NLK 17q11.2 / NF1 17q11.2NLK 17q11.2 / RAD51D 17q12TADA2A 17q12 / NLK 17q11.2
WRB 21q22.2 / NLK 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NLK   29858
Cards
Entrez_Gene (NCBI)NLK    nemo like kinase
Aliases
GeneCards (Weizmann)NLK
Ensembl hg19 (Hinxton)ENSG00000087095 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087095 [Gene_View]  ENSG00000087095 [Sequence]  chr17:28042677-28196378 [Contig_View]  NLK [Vega]
ICGC DataPortalENSG00000087095
TCGA cBioPortalNLK
AceView (NCBI)NLK
Genatlas (Paris)NLK
SOURCE (Princeton)NLK
Genetics Home Reference (NIH)NLK
Genomic and cartography
GoldenPath hg38 (UCSC)NLK  -     chr17:28042677-28196378 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLK  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathNLK - 17q11.2 [CytoView hg19]  NLK - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000087095
Genome Data Viewer NCBINLK [Mapview hg19]  
OMIM609476   
Gene and transcription
Genbank (Entrez)AF180819 AF197898 AK024686 AK315315 AL036279
RefSeq transcript (Entrez)NM_016231
Consensus coding sequences : CCDS (NCBI)NLK
Gene ExpressionNLK [ NCBI-GEO ]   NLK [ EBI - ARRAY_EXPRESS ]   NLK [ SEEK ]   NLK [ MEM ]
Gene Expression Viewer (FireBrowse)NLK [ Firebrowse - Broad ]
GenevisibleExpression of NLK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51701
GTEX Portal (Tissue expression)NLK
Human Protein AtlasENSG00000087095-NLK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBE8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBE8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBE8
Catalytic activity : Enzyme2.7.11.24 [ Enzyme-Expasy ]   2.7.11.242.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UBE8
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MAP_kinase_CS    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NLK
SuperfamilyQ9UBE8
AlphaFold pdb e-kbQ9UBE8   
Human Protein Atlas [tissue]ENSG00000087095-NLK [tissue]
HPRD17637
Protein Interaction databases
DIP (DOE-UCLA)Q9UBE8
IntAct (EBI)Q9UBE8
BioGRIDNLK
STRING (EMBL)NLK
ZODIACNLK
Ontologies - Pathways
QuickGOQ9UBE8
Ontology : AmiGOMAPK cascade  magnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein phosphorylation  transforming growth factor beta receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  transcription factor binding  peptidyl-threonine phosphorylation  negative regulation of Wnt signaling pathway  ubiquitin protein ligase binding  intracellular signal transduction  intracellular signal transduction  SH2 domain binding  serine phosphorylation of STAT protein  protein autophosphorylation  protein stabilization  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIMAPK cascade  magnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  protein phosphorylation  transforming growth factor beta receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  transcription factor binding  peptidyl-threonine phosphorylation  negative regulation of Wnt signaling pathway  ubiquitin protein ligase binding  intracellular signal transduction  intracellular signal transduction  SH2 domain binding  serine phosphorylation of STAT protein  protein autophosphorylation  protein stabilization  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAWNT Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    FoxO signaling pathway    Wnt signaling pathway    Adherens junction   
NDEx NetworkNLK
Atlas of Cancer Signalling NetworkNLK
Wikipedia pathwaysNLK
Orthology - Evolution
OrthoDB51701
GeneTree (enSembl)ENSG00000087095
Phylogenetic Trees/Animal Genes : TreeFamNLK
Homologs : HomoloGeneNLK
Homology/Alignments : Family Browser (UCSC)NLK
Gene fusions - Rearrangements
Fusion : MitelmanKHDC1/NLK [6q13/17q11.2]  
Fusion : MitelmanNLK/BCAS3 [17q11.2/17q23.2]  
Fusion : MitelmanNLK/DUSP14 [17q11.2/17q12]  
Fusion : MitelmanNLK/KALRN [17q11.2/3q21.2]  
Fusion : MitelmanNLK/NF1 [17q11.2/17q11.2]  
Fusion : MitelmanNLK/RAD51D [17q11.2/17q12]  
Fusion : MitelmanTADA2A/NLK [17q12/17q11.2]  
Fusion : MitelmanWRB/NLK [21q22.2/17q11.2]  
Fusion : QuiverNLK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLK
dbVarNLK
ClinVarNLK
MonarchNLK
1000_GenomesNLK 
Exome Variant ServerNLK
GNOMAD BrowserENSG00000087095
Varsome BrowserNLK
ACMGNLK variants
VarityQ9UBE8
Genomic Variants (DGV)NLK [DGVbeta]
DECIPHERNLK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLK 
Mutations
ICGC Data PortalNLK 
TCGA Data PortalNLK 
Broad Tumor PortalNLK
OASIS PortalNLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLK
Mutations and Diseases : HGMDNLK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNLK
DgiDB (Drug Gene Interaction Database)NLK
DoCM (Curated mutations)NLK
CIViC (Clinical Interpretations of Variants in Cancer)NLK
Cancer3DNLK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609476   
Orphanet
DisGeNETNLK
MedgenNLK
Genetic Testing Registry NLK
NextProtQ9UBE8 [Medical]
GENETestsNLK
Target ValidationNLK
Huge Navigator NLK [HugePedia]
ClinGenNLK
Clinical trials, drugs, therapy
MyCancerGenomeNLK
Protein Interactions : CTDNLK
Pharm GKB GenePA134914500
PharosQ9UBE8
Clinical trialNLK
Miscellaneous
canSAR (ICR)NLK
HarmonizomeNLK
DataMed IndexNLK
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:52 CEST 2021

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