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NLK (nemo-like kinase)

Identity

Alias_namesnemo-like kinase
Other alias-
HGNC (Hugo) NLK
LocusID (NCBI) 51701
Atlas_Id 43380
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 26369688 and ends at 26523404 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KHDC1 (6q13) / NLK (17q11.2)NLK (17q11.2) / BCAS3 (17q23.2)NLK (17q11.2) / DUSP14 (17q12)
NLK (17q11.2) / KALRN (3q21.2)NLK (17q11.2) / NF1 (17q11.2)NLK (17q11.2) / NLK (17q11.2)
NLK (17q11.2) / PPP1R1B (17q12)NLK (17q11.2) / RAD51D (17q12)TADA2A (17q12) / NLK (17q11.2)
USP32 (17q23.1) / NLK (17q11.2)WRB (21q22.2) / NLK (17q11.2)KHDC1 6q13 / NLK 17q11.2
NLK 17q11.2 / BCAS3 17q23.2NLK 17q11.2 / DUSP14 17q12NLK 17q11.2 / KALRN 3q21.2
NLK 17q11.2 / NF1 17q11.2NLK 17q11.2 / RAD51D 17q12TADA2A 17q12 / NLK 17q11.2
WRB 21q22.2 / NLK 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLK   29858
Cards
Entrez_Gene (NCBI)NLK  51701  nemo-like kinase
Aliases
GeneCards (Weizmann)NLK
Ensembl hg19 (Hinxton)ENSG00000087095 [Gene_View]  chr17:26369688-26523404 [Contig_View]  NLK [Vega]
Ensembl hg38 (Hinxton)ENSG00000087095 [Gene_View]  chr17:26369688-26523404 [Contig_View]  NLK [Vega]
ICGC DataPortalENSG00000087095
TCGA cBioPortalNLK
AceView (NCBI)NLK
Genatlas (Paris)NLK
WikiGenes51701
SOURCE (Princeton)NLK
Genetics Home Reference (NIH)NLK
Genomic and cartography
GoldenPath hg19 (UCSC)NLK  -     chr17:26369688-26523404 +  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NLK  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblNLK - 17q11.2 [CytoView hg19]  NLK - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBINLK [Mapview hg19]  NLK [Mapview hg38]
OMIM609476   
Gene and transcription
Genbank (Entrez)AF180819 AF197898 AK024686 AK315315 AL036279
RefSeq transcript (Entrez)NM_016231
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NLK
Cluster EST : UnigeneHs.208759 [ NCBI ]
CGAP (NCI)Hs.208759
Alternative Splicing GalleryENSG00000087095
Gene ExpressionNLK [ NCBI-GEO ]   NLK [ EBI - ARRAY_EXPRESS ]   NLK [ SEEK ]   NLK [ MEM ]
Gene Expression Viewer (FireBrowse)NLK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51701
GTEX Portal (Tissue expression)NLK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBE8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBE8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBE8
Splice isoforms : SwissVarQ9UBE8
Catalytic activity : Enzyme2.7.11.24 [ Enzyme-Expasy ]   2.7.11.242.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   
PhosPhoSitePlusQ9UBE8
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAP_kinase_CS    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NLK
DMDM Disease mutations51701
Blocks (Seattle)NLK
SuperfamilyQ9UBE8
Human Protein AtlasENSG00000087095
Peptide AtlasQ9UBE8
HPRD17637
IPIIPI00936281   IPI00980020   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBE8
IntAct (EBI)Q9UBE8
FunCoupENSG00000087095
BioGRIDNLK
STRING (EMBL)NLK
ZODIACNLK
Ontologies - Pathways
QuickGOQ9UBE8
Ontology : AmiGOMAPK cascade  magnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  transforming growth factor beta receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  transcription factor binding  peptidyl-threonine phosphorylation  negative regulation of Wnt signaling pathway  ubiquitin protein ligase binding  serine phosphorylation of STAT3 protein  intracellular signal transduction  SH2 domain binding  protein autophosphorylation  protein stabilization  
Ontology : EGO-EBIMAPK cascade  magnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  transforming growth factor beta receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  transcription factor binding  peptidyl-threonine phosphorylation  negative regulation of Wnt signaling pathway  ubiquitin protein ligase binding  serine phosphorylation of STAT3 protein  intracellular signal transduction  SH2 domain binding  protein autophosphorylation  protein stabilization  
Pathways : BIOCARTAWNT Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    FoxO signaling pathway    Wnt signaling pathway    Adherens junction   
NDEx NetworkNLK
Atlas of Cancer Signalling NetworkNLK
Wikipedia pathwaysNLK
Orthology - Evolution
OrthoDB51701
GeneTree (enSembl)ENSG00000087095
Phylogenetic Trees/Animal Genes : TreeFamNLK
HOVERGENQ9UBE8
HOGENOMQ9UBE8
Homologs : HomoloGeneNLK
Homology/Alignments : Family Browser (UCSC)NLK
Gene fusions - Rearrangements
Fusion : MitelmanKHDC1/NLK [6q13/17q11.2]  [t(6;17)(q13;q11)]  
Fusion : MitelmanNLK/BCAS3 [17q11.2/17q23.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanNLK/DUSP14 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanNLK/KALRN [17q11.2/3q21.2]  [t(3;17)(q21;q11)]  
Fusion : MitelmanNLK/NF1 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanNLK/RAD51D [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanTADA2A/NLK [17q12/17q11.2]  [t(17;17)(q11;q12)]  
Fusion : MitelmanWRB/NLK [21q22.2/17q11.2]  [t(17;21)(q11;q22)]  
Fusion: TCGAKHDC1 6q13 NLK 17q11.2 BRCA
Fusion: TCGANLK 17q11.2 BCAS3 17q23.2 BRCA
Fusion: TCGANLK 17q11.2 DUSP14 17q12 BRCA
Fusion: TCGANLK 17q11.2 KALRN 3q21.2 KIRC
Fusion: TCGANLK 17q11.2 NF1 17q11.2 LUAD
Fusion: TCGANLK 17q11.2 RAD51D 17q12 HNSC
Fusion: TCGATADA2A 17q12 NLK 17q11.2 BRCA
Fusion: TCGAWRB 21q22.2 NLK 17q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLK
dbVarNLK
ClinVarNLK
1000_GenomesNLK 
Exome Variant ServerNLK
ExAC (Exome Aggregation Consortium)NLK (select the gene name)
Genetic variants : HAPMAP51701
Genomic Variants (DGV)NLK [DGVbeta]
DECIPHER (Syndromes)17:26369688-26523404  ENSG00000087095
CONAN: Copy Number AnalysisNLK 
Mutations
ICGC Data PortalNLK 
TCGA Data PortalNLK 
Broad Tumor PortalNLK
OASIS PortalNLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLK
DgiDB (Drug Gene Interaction Database)NLK
DoCM (Curated mutations)NLK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLK (select a term)
intoGenNLK
Cancer3DNLK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609476   
Orphanet
MedgenNLK
Genetic Testing Registry NLK
NextProtQ9UBE8 [Medical]
TSGene51701
GENETestsNLK
Huge Navigator NLK [HugePedia]
snp3D : Map Gene to Disease51701
BioCentury BCIQNLK
ClinGenNLK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51701
Chemical/Pharm GKB GenePA134914500
Clinical trialNLK
Miscellaneous
canSAR (ICR)NLK (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLK
EVEXNLK
GoPubMedNLK
iHOPNLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:18:56 CET 2017

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