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NLN (neurolysin)

Identity

Alias (NCBI)AGTBP
EP24.16
MEP
MOP
HGNC (Hugo) NLN
HGNC Alias symbKIAA1226
HGNC Alias nameneurotensin endopeptidase
HGNC Previous nameAGTBP
HGNC Previous nameangiotensin binding protein
 neurolysin (metallopeptidase M3 family)
LocusID (NCBI) 57486
Atlas_Id 70868
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65722205 and ends at 65829283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERBIN (5q12.3) / NLN (5q12.3)MAST4 (5q12.3) / NLN (5q12.3)NLN (5q12.3) / MAP2K3 (17p11.2)
MAST4 NLNERBB2IP NLN

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NLN   16058
Cards
Entrez_Gene (NCBI)NLN    neurolysin
AliasesAGTBP; EP24.16; MEP; MOP
GeneCards (Weizmann)NLN
Ensembl hg19 (Hinxton)ENSG00000123213 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123213 [Gene_View]  ENSG00000123213 [Sequence]  chr5:65722205-65829283 [Contig_View]  NLN [Vega]
ICGC DataPortalENSG00000123213
TCGA cBioPortalNLN
AceView (NCBI)NLN
Genatlas (Paris)NLN
SOURCE (Princeton)NLN
Genetics Home Reference (NIH)NLN
Genomic and cartography
GoldenPath hg38 (UCSC)NLN  -     chr5:65722205-65829283 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLN  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathNLN - 5q12.3 [CytoView hg19]  NLN - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000123213
Genome Data Viewer NCBINLN [Mapview hg19]  
OMIM611530   
Gene and transcription
Genbank (Entrez)AB033052 AJ300837 AK026655 AK027602 AK096416
RefSeq transcript (Entrez)NM_020726
Consensus coding sequences : CCDS (NCBI)NLN
Gene ExpressionNLN [ NCBI-GEO ]   NLN [ EBI - ARRAY_EXPRESS ]   NLN [ SEEK ]   NLN [ MEM ]
Gene Expression Viewer (FireBrowse)NLN [ Firebrowse - Broad ]
GenevisibleExpression of NLN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57486
GTEX Portal (Tissue expression)NLN
Human Protein AtlasENSG00000123213-NLN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYT8
Catalytic activity : Enzyme3.4.24.16 [ Enzyme-Expasy ]   3.4.24.163.4.24.16 [ IntEnz-EBI ]   3.4.24.16 [ BRENDA ]   3.4.24.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BYT8
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)MetalloPept_cat_dom_sf    Neurolysin/TOP_dom2    Neurolysin/TOP_N    Pept_M3A_M3B   
Domain families : Pfam (Sanger)Peptidase_M3 (PF01432)   
Domain families : Pfam (NCBI)pfam01432   
Conserved Domain (NCBI)NLN
PDB (RSDB)5LUZ    5LV0   
PDB Europe5LUZ    5LV0   
PDB (PDBSum)5LUZ    5LV0   
PDB (IMB)5LUZ    5LV0   
Structural Biology KnowledgeBase5LUZ    5LV0   
SCOP (Structural Classification of Proteins)5LUZ    5LV0   
CATH (Classification of proteins structures)5LUZ    5LV0   
SuperfamilyQ9BYT8
AlphaFold pdb e-kbQ9BYT8   
Human Protein Atlas [tissue]ENSG00000123213-NLN [tissue]
HPRD07495
Protein Interaction databases
DIP (DOE-UCLA)Q9BYT8
IntAct (EBI)Q9BYT8
BioGRIDNLN
STRING (EMBL)NLN
ZODIACNLN
Ontologies - Pathways
QuickGOQ9BYT8
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  mitochondrial intermembrane space  plasma membrane  regulation of gluconeogenesis  proteolysis  peptide metabolic process  G protein-coupled receptor signaling pathway  peptide binding  metal ion binding  regulation of skeletal muscle fiber differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  mitochondrial intermembrane space  plasma membrane  regulation of gluconeogenesis  proteolysis  peptide metabolic process  G protein-coupled receptor signaling pathway  peptide binding  metal ion binding  regulation of skeletal muscle fiber differentiation  
NDEx NetworkNLN
Atlas of Cancer Signalling NetworkNLN
Wikipedia pathwaysNLN
Orthology - Evolution
OrthoDB57486
GeneTree (enSembl)ENSG00000123213
Phylogenetic Trees/Animal Genes : TreeFamNLN
Homologs : HomoloGeneNLN
Homology/Alignments : Family Browser (UCSC)NLN
Gene fusions - Rearrangements
Fusion : QuiverNLN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLN
dbVarNLN
ClinVarNLN
MonarchNLN
1000_GenomesNLN 
Exome Variant ServerNLN
GNOMAD BrowserENSG00000123213
Varsome BrowserNLN
ACMGNLN variants
VarityQ9BYT8
Genomic Variants (DGV)NLN [DGVbeta]
DECIPHERNLN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLN 
Mutations
ICGC Data PortalNLN 
TCGA Data PortalNLN 
Broad Tumor PortalNLN
OASIS PortalNLN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLN
Mutations and Diseases : HGMDNLN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNLN
DgiDB (Drug Gene Interaction Database)NLN
DoCM (Curated mutations)NLN
CIViC (Clinical Interpretations of Variants in Cancer)NLN
Cancer3DNLN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611530   
Orphanet
DisGeNETNLN
MedgenNLN
Genetic Testing Registry NLN
NextProtQ9BYT8 [Medical]
GENETestsNLN
Target ValidationNLN
Huge Navigator NLN [HugePedia]
ClinGenNLN
Clinical trials, drugs, therapy
MyCancerGenomeNLN
Protein Interactions : CTDNLN
Pharm GKB GenePA31651
PharosQ9BYT8
Clinical trialNLN
Miscellaneous
canSAR (ICR)NLN
HarmonizomeNLN
DataMed IndexNLN
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNLN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:49 CEST 2021

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