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NLN (neurolysin)

Identity

Alias_namesAGTBP
angiotensin binding protein
neurolysin (metallopeptidase M3 family)
Alias_symbol (synonym)KIAA1226
Other aliasEP24.16
MEP
MOP
HGNC (Hugo) NLN
LocusID (NCBI) 57486
Atlas_Id 70868
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65722196 and ends at 65829283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERBIN (5q12.3) / NLN (5q12.3)MAST4 (5q12.3) / NLN (5q12.3)NLN (5q12.3) / MAP2K3 (17p11.2)
MAST4 NLNERBB2IP NLN

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLN   16058
Cards
Entrez_Gene (NCBI)NLN  57486  neurolysin
AliasesAGTBP; EP24.16; MEP; MOP
GeneCards (Weizmann)NLN
Ensembl hg19 (Hinxton)ENSG00000123213 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123213 [Gene_View]  chr5:65722196-65829283 [Contig_View]  NLN [Vega]
ICGC DataPortalENSG00000123213
TCGA cBioPortalNLN
AceView (NCBI)NLN
Genatlas (Paris)NLN
WikiGenes57486
SOURCE (Princeton)NLN
Genetics Home Reference (NIH)NLN
Genomic and cartography
GoldenPath hg38 (UCSC)NLN  -     chr5:65722196-65829283 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLN  -     5q12.3   [Description]    (hg19-Feb_2009)
EnsemblNLN - 5q12.3 [CytoView hg19]  NLN - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBINLN [Mapview hg19]  NLN [Mapview hg38]
OMIM611530   
Gene and transcription
Genbank (Entrez)AB033052 AB463138 AJ300837 AK026655 AK027602
RefSeq transcript (Entrez)NM_020726
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLN
Cluster EST : UnigeneHs.247460 [ NCBI ]
CGAP (NCI)Hs.247460
Alternative Splicing GalleryENSG00000123213
Gene ExpressionNLN [ NCBI-GEO ]   NLN [ EBI - ARRAY_EXPRESS ]   NLN [ SEEK ]   NLN [ MEM ]
Gene Expression Viewer (FireBrowse)NLN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57486
GTEX Portal (Tissue expression)NLN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYT8
Splice isoforms : SwissVarQ9BYT8
Catalytic activity : Enzyme3.4.24.16 [ Enzyme-Expasy ]   3.4.24.163.4.24.16 [ IntEnz-EBI ]   3.4.24.16 [ BRENDA ]   3.4.24.16 [ KEGG ]   
PhosPhoSitePlusQ9BYT8
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)MetalloPept_cat_dom    Neurolysin/TOP_dom2    Neurolysin/TOP_N    Pept_M3A_M3B   
Domain families : Pfam (Sanger)Peptidase_M3 (PF01432)   
Domain families : Pfam (NCBI)pfam01432   
Conserved Domain (NCBI)NLN
DMDM Disease mutations57486
Blocks (Seattle)NLN
SuperfamilyQ9BYT8
Human Protein AtlasENSG00000123213
Peptide AtlasQ9BYT8
HPRD07495
IPIIPI00010346   IPI01015957   IPI00872224   IPI00965474   IPI00966066   IPI00965192   IPI00965753   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYT8
IntAct (EBI)Q9BYT8
FunCoupENSG00000123213
BioGRIDNLN
STRING (EMBL)NLN
ZODIACNLN
Ontologies - Pathways
QuickGOQ9BYT8
Ontology : AmiGOmetalloendopeptidase activity  metalloendopeptidase activity  extracellular region  mitochondrial intermembrane space  plasma membrane  regulation of gluconeogenesis  proteolysis  peptide metabolic process  peptide binding  metal ion binding  regulation of skeletal muscle fiber differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  metalloendopeptidase activity  extracellular region  mitochondrial intermembrane space  plasma membrane  regulation of gluconeogenesis  proteolysis  peptide metabolic process  peptide binding  metal ion binding  regulation of skeletal muscle fiber differentiation  
Pathways : KEGGRenin-angiotensin system   
NDEx NetworkNLN
Atlas of Cancer Signalling NetworkNLN
Wikipedia pathwaysNLN
Orthology - Evolution
OrthoDB57486
GeneTree (enSembl)ENSG00000123213
Phylogenetic Trees/Animal Genes : TreeFamNLN
HOVERGENQ9BYT8
HOGENOMQ9BYT8
Homologs : HomoloGeneNLN
Homology/Alignments : Family Browser (UCSC)NLN
Gene fusions - Rearrangements
Fusion: TCGAMAST4 NLN
Fusion: TCGAERBB2IP NLN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLN
dbVarNLN
ClinVarNLN
1000_GenomesNLN 
Exome Variant ServerNLN
ExAC (Exome Aggregation Consortium)NLN (select the gene name)
Genetic variants : HAPMAP57486
Genomic Variants (DGV)NLN [DGVbeta]
DECIPHERNLN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLN 
Mutations
ICGC Data PortalNLN 
TCGA Data PortalNLN 
Broad Tumor PortalNLN
OASIS PortalNLN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NLN
DgiDB (Drug Gene Interaction Database)NLN
DoCM (Curated mutations)NLN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLN (select a term)
intoGenNLN
Cancer3DNLN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611530   
Orphanet
MedgenNLN
Genetic Testing Registry NLN
NextProtQ9BYT8 [Medical]
TSGene57486
GENETestsNLN
Target ValidationNLN
Huge Navigator NLN [HugePedia]
snp3D : Map Gene to Disease57486
BioCentury BCIQNLN
ClinGenNLN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57486
Chemical/Pharm GKB GenePA31651
Clinical trialNLN
Miscellaneous
canSAR (ICR)NLN (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLN
EVEXNLN
GoPubMedNLN
iHOPNLN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:45 CEST 2017

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