NLRC3 (NLR family CARD domain containing 3)

2015-03-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
CLR16.2,NOD3
FUSION GENES

Other Information

Locus ID:

NCBI: 197358
MIM: 615648
HGNC: 29889
Ensembl: ENSG00000167984

Variants:

dbSNP: 197358
ClinVar: 197358
TCGA: ENSG00000167984
COSMIC: NLRC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167984ENST00000324659H3BLT9
ENSG00000167984ENST00000359128Q7RTR2
ENSG00000167984ENST00000359128C3VPR7
ENSG00000167984ENST00000615877Q7RTR2
ENSG00000167984ENST00000618137A0A087WZ24

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619

References

Pubmed IDYearTitleCitations
228637532012The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.92
157055852005CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function.47
267639802016Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure.23
263780202015Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components.21
227187702012Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3.12
252771062015Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein.7
285840532017NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding.5
300811502018The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma.3
287311422017NLRC3 promotes host resistance against Pseudomonas aeruginosa-induced keratitis by promoting the degradation of IRAK1.2
313036172019[Association of NLRC3 with prognosis and tumor immunity in patients with stage III colorectal cancer].0

Citation

Dessen P

NLRC3 (NLR family CARD domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55120/nlrc3