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NLRC3 (NLR family CARD domain containing 3)

Identity

Alias_symbol (synonym)CLR16.2
FLJ00348
NOD3
Other alias
HGNC (Hugo) NLRC3
LocusID (NCBI) 197358
Atlas_Id 55120
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3539036 and ends at 3577404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NLRC3 (16p13.3) / NLRC3 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLRC3   29889
Cards
Entrez_Gene (NCBI)NLRC3  197358  NLR family CARD domain containing 3
AliasesCLR16.2; NOD3
GeneCards (Weizmann)NLRC3
Ensembl hg19 (Hinxton)ENSG00000167984 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167984 [Gene_View]  chr16:3539036-3577404 [Contig_View]  NLRC3 [Vega]
ICGC DataPortalENSG00000167984
TCGA cBioPortalNLRC3
AceView (NCBI)NLRC3
Genatlas (Paris)NLRC3
WikiGenes197358
SOURCE (Princeton)NLRC3
Genetics Home Reference (NIH)NLRC3
Genomic and cartography
GoldenPath hg38 (UCSC)NLRC3  -     chr16:3539036-3577404 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRC3  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblNLRC3 - 16p13.3 [CytoView hg19]  NLRC3 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBINLRC3 [Mapview hg19]  NLRC3 [Mapview hg38]
OMIM615648   
Gene and transcription
Genbank (Entrez)AF501291 AF501292 AK074109 AK090431 AK090476
RefSeq transcript (Entrez)NM_178844
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLRC3
Cluster EST : UnigeneHs.741496 [ NCBI ]
CGAP (NCI)Hs.741496
Alternative Splicing GalleryENSG00000167984
Gene ExpressionNLRC3 [ NCBI-GEO ]   NLRC3 [ EBI - ARRAY_EXPRESS ]   NLRC3 [ SEEK ]   NLRC3 [ MEM ]
Gene Expression Viewer (FireBrowse)NLRC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)197358
GTEX Portal (Tissue expression)NLRC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7RTR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7RTR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7RTR2
Splice isoforms : SwissVarQ7RTR2
PhosPhoSitePlusQ7RTR2
Domaine pattern : Prosite (Expaxy)NACHT (PS50837)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    NACHT_NTPase   
Domain families : Pfam (Sanger)LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam13516   
Conserved Domain (NCBI)NLRC3
DMDM Disease mutations197358
Blocks (Seattle)NLRC3
SuperfamilyQ7RTR2
Human Protein AtlasENSG00000167984
Peptide AtlasQ7RTR2
HPRD17639
IPIIPI00854840   IPI00385743   IPI00854580   IPI00333975   IPI00952613   IPI01018305   IPI00386174   
Protein Interaction databases
DIP (DOE-UCLA)Q7RTR2
IntAct (EBI)Q7RTR2
FunCoupENSG00000167984
BioGRIDNLRC3
STRING (EMBL)NLRC3
ZODIACNLRC3
Ontologies - Pathways
QuickGOQ7RTR2
Ontology : AmiGOmolecular_function  protein binding  ATP binding  cytoplasm  microtubule organizing center  cytosol  I-kappaB kinase/NF-kappaB signaling  negative regulation of phosphatidylinositol 3-kinase signaling  negative regulation of NF-kappaB transcription factor activity  negative regulation of interferon-alpha production  negative regulation of interferon-beta production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  negative regulation of tumor necrosis factor production  phosphatidylinositol 3-kinase regulatory subunit binding  T cell activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of innate immune response  negative regulation of fibroblast proliferation  perinuclear region of cytoplasm  negative regulation of epithelial cell proliferation  negative regulation of inflammatory response  negative regulation of cytokine production involved in inflammatory response  negative regulation of NLRP3 inflammasome complex assembly  negative regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBImolecular_function  protein binding  ATP binding  cytoplasm  microtubule organizing center  cytosol  I-kappaB kinase/NF-kappaB signaling  negative regulation of phosphatidylinositol 3-kinase signaling  negative regulation of NF-kappaB transcription factor activity  negative regulation of interferon-alpha production  negative regulation of interferon-beta production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  negative regulation of tumor necrosis factor production  phosphatidylinositol 3-kinase regulatory subunit binding  T cell activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of innate immune response  negative regulation of fibroblast proliferation  perinuclear region of cytoplasm  negative regulation of epithelial cell proliferation  negative regulation of inflammatory response  negative regulation of cytokine production involved in inflammatory response  negative regulation of NLRP3 inflammasome complex assembly  negative regulation of NIK/NF-kappaB signaling  
NDEx NetworkNLRC3
Atlas of Cancer Signalling NetworkNLRC3
Wikipedia pathwaysNLRC3
Orthology - Evolution
OrthoDB197358
GeneTree (enSembl)ENSG00000167984
Phylogenetic Trees/Animal Genes : TreeFamNLRC3
HOVERGENQ7RTR2
HOGENOMQ7RTR2
Homologs : HomoloGeneNLRC3
Homology/Alignments : Family Browser (UCSC)NLRC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRC3
dbVarNLRC3
ClinVarNLRC3
1000_GenomesNLRC3 
Exome Variant ServerNLRC3
ExAC (Exome Aggregation Consortium)NLRC3 (select the gene name)
Genetic variants : HAPMAP197358
Genomic Variants (DGV)NLRC3 [DGVbeta]
DECIPHERNLRC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRC3 
Mutations
ICGC Data PortalNLRC3 
TCGA Data PortalNLRC3 
Broad Tumor PortalNLRC3
OASIS PortalNLRC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLRC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLRC3
DgiDB (Drug Gene Interaction Database)NLRC3
DoCM (Curated mutations)NLRC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLRC3 (select a term)
intoGenNLRC3
Cancer3DNLRC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615648   
Orphanet
MedgenNLRC3
Genetic Testing Registry NLRC3
NextProtQ7RTR2 [Medical]
TSGene197358
GENETestsNLRC3
Target ValidationNLRC3
Huge Navigator NLRC3 [HugePedia]
snp3D : Map Gene to Disease197358
BioCentury BCIQNLRC3
ClinGenNLRC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD197358
Chemical/Pharm GKB GenePA162397626
Clinical trialNLRC3
Miscellaneous
canSAR (ICR)NLRC3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLRC3
EVEXNLRC3
GoPubMedNLRC3
iHOPNLRC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:10 CEST 2017

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