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NLRC5 (NLR family CARD domain containing 5)

Identity

Alias_symbol (synonym)NOD27
CLR16.1
FLJ21709
Other aliasNOD4
HGNC (Hugo) NLRC5
LocusID (NCBI) 84166
Atlas_Id 56616
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56989485 and ends at 57083524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GLYAT (11q12.1) / NLRC5 (16q13)HCLS1 (3q13.33) / NLRC5 (16q13)NLRC5 (16q13) / PUM1 (1p35.2)
PUM1 (1p35.2) / NLRC5 (16q13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLRC5   29933
Cards
Entrez_Gene (NCBI)NLRC5  84166  NLR family CARD domain containing 5
AliasesCLR16.1; NOD27; NOD4
GeneCards (Weizmann)NLRC5
Ensembl hg19 (Hinxton)ENSG00000140853 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140853 [Gene_View]  chr16:56989485-57083524 [Contig_View]  NLRC5 [Vega]
ICGC DataPortalENSG00000140853
TCGA cBioPortalNLRC5
AceView (NCBI)NLRC5
Genatlas (Paris)NLRC5
WikiGenes84166
SOURCE (Princeton)NLRC5
Genetics Home Reference (NIH)NLRC5
Genomic and cartography
GoldenPath hg38 (UCSC)NLRC5  -     chr16:56989485-57083524 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRC5  -     16q13   [Description]    (hg19-Feb_2009)
EnsemblNLRC5 - 16q13 [CytoView hg19]  NLRC5 - 16q13 [CytoView hg38]
Mapping of homologs : NCBINLRC5 [Mapview hg19]  NLRC5 [Mapview hg38]
OMIM613537   
Gene and transcription
Genbank (Entrez)AA722775 AF389420 AK025212 AK025362 AK027414
RefSeq transcript (Entrez)NM_001330552 NM_032206
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLRC5
Cluster EST : UnigeneHs.528836 [ NCBI ]
CGAP (NCI)Hs.528836
Alternative Splicing GalleryENSG00000140853
Gene ExpressionNLRC5 [ NCBI-GEO ]   NLRC5 [ EBI - ARRAY_EXPRESS ]   NLRC5 [ SEEK ]   NLRC5 [ MEM ]
Gene Expression Viewer (FireBrowse)NLRC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84166
GTEX Portal (Tissue expression)NLRC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WI3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WI3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WI3
Splice isoforms : SwissVarQ86WI3
PhosPhoSitePlusQ86WI3
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    NACHT (PS50837)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_4    Leu-rich_rpt_Cys-con_subtyp    NACHT_NTPase    P-loop_NTPase   
Domain families : Pfam (Sanger)LRR_4 (PF12799)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12799    pfam13516   
Domain families : Smart (EMBL)LRR_CC (SM00367)  
Conserved Domain (NCBI)NLRC5
DMDM Disease mutations84166
Blocks (Seattle)NLRC5
SuperfamilyQ86WI3
Human Protein AtlasENSG00000140853
Peptide AtlasQ86WI3
HPRD14831
IPIIPI00789837   IPI00329085   IPI00647281   IPI00383061   IPI00854610   IPI00641739   IPI00335249   IPI01013672   IPI01010690   IPI01009791   IPI01009300   IPI01012382   IPI01011911   IPI01011448   
Protein Interaction databases
DIP (DOE-UCLA)Q86WI3
IntAct (EBI)Q86WI3
FunCoupENSG00000140853
BioGRIDNLRC5
STRING (EMBL)NLRC5
ZODIACNLRC5
Ontologies - Pathways
QuickGOQ86WI3
Ontology : AmiGORNA polymerase II core promoter sequence-specific DNA binding  protein binding  ATP binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  negative regulation of NF-kappaB transcription factor activity  negative regulation of type I interferon production  regulation of kinase activity  innate immune response  positive regulation of MHC class I biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  positive regulation of interferon-gamma-mediated signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  negative regulation of type I interferon-mediated signaling pathway  positive regulation of type I interferon-mediated signaling pathway  
Ontology : EGO-EBIRNA polymerase II core promoter sequence-specific DNA binding  protein binding  ATP binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  negative regulation of NF-kappaB transcription factor activity  negative regulation of type I interferon production  regulation of kinase activity  innate immune response  positive regulation of MHC class I biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  positive regulation of interferon-gamma-mediated signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  negative regulation of type I interferon-mediated signaling pathway  positive regulation of type I interferon-mediated signaling pathway  
NDEx NetworkNLRC5
Atlas of Cancer Signalling NetworkNLRC5
Wikipedia pathwaysNLRC5
Orthology - Evolution
OrthoDB84166
GeneTree (enSembl)ENSG00000140853
Phylogenetic Trees/Animal Genes : TreeFamNLRC5
HOVERGENQ86WI3
HOGENOMQ86WI3
Homologs : HomoloGeneNLRC5
Homology/Alignments : Family Browser (UCSC)NLRC5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRC5
dbVarNLRC5
ClinVarNLRC5
1000_GenomesNLRC5 
Exome Variant ServerNLRC5
ExAC (Exome Aggregation Consortium)NLRC5 (select the gene name)
Genetic variants : HAPMAP84166
Genomic Variants (DGV)NLRC5 [DGVbeta]
DECIPHERNLRC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRC5 
Mutations
ICGC Data PortalNLRC5 
TCGA Data PortalNLRC5 
Broad Tumor PortalNLRC5
OASIS PortalNLRC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLRC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLRC5
DgiDB (Drug Gene Interaction Database)NLRC5
DoCM (Curated mutations)NLRC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLRC5 (select a term)
intoGenNLRC5
Cancer3DNLRC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613537   
Orphanet
MedgenNLRC5
Genetic Testing Registry NLRC5
NextProtQ86WI3 [Medical]
TSGene84166
GENETestsNLRC5
Target ValidationNLRC5
Huge Navigator NLRC5 [HugePedia]
snp3D : Map Gene to Disease84166
BioCentury BCIQNLRC5
ClinGenNLRC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84166
Chemical/Pharm GKB GenePA162397694
Clinical trialNLRC5
Miscellaneous
canSAR (ICR)NLRC5 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLRC5
EVEXNLRC5
GoPubMedNLRC5
iHOPNLRC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:10 CEST 2017

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