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NLRP5 (NLR family pyrin domain containing 5)

Identity

Alias (NCBI)CLR19.8
MATER
NALP5
PAN11
PYPAF8
HGNC (Hugo) NLRP5
HGNC Alias symbPYPAF8
MATER
PAN11
CLR19.8
HGNC Alias namenucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
 maternal antigen that embryos require
HGNC Previous nameNALP5
HGNC Previous nameNACHT, leucine rich repeat and PYD containing 5
LocusID (NCBI) 126206
Atlas_Id 70877
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 55999726 and ends at 56061808 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF492 (19p12) / NLRP5 (19q13.43)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NLRP5   21269
Cards
Entrez_Gene (NCBI)NLRP5    NLR family pyrin domain containing 5
AliasesCLR19.8; MATER; NALP5; PAN11; 
PYPAF8
GeneCards (Weizmann)NLRP5
Ensembl hg19 (Hinxton)ENSG00000171487 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171487 [Gene_View]  ENSG00000171487 [Sequence]  chr19:55999726-56061808 [Contig_View]  NLRP5 [Vega]
ICGC DataPortalENSG00000171487
TCGA cBioPortalNLRP5
AceView (NCBI)NLRP5
Genatlas (Paris)NLRP5
SOURCE (Princeton)NLRP5
Genetics Home Reference (NIH)NLRP5
Genomic and cartography
GoldenPath hg38 (UCSC)NLRP5  -     chr19:55999726-56061808 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRP5  -     19q13.43   [Description]    (hg19-Feb_2009)
GoldenPathNLRP5 - 19q13.43 [CytoView hg19]  NLRP5 - 19q13.43 [CytoView hg38]
ImmunoBaseENSG00000171487
Genome Data Viewer NCBINLRP5 [Mapview hg19]  
OMIM609658   
Gene and transcription
Genbank (Entrez)AY054986 AY154460
RefSeq transcript (Entrez)NM_153447
Consensus coding sequences : CCDS (NCBI)NLRP5
Gene ExpressionNLRP5 [ NCBI-GEO ]   NLRP5 [ EBI - ARRAY_EXPRESS ]   NLRP5 [ SEEK ]   NLRP5 [ MEM ]
Gene Expression Viewer (FireBrowse)NLRP5 [ Firebrowse - Broad ]
GenevisibleExpression of NLRP5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)126206
GTEX Portal (Tissue expression)NLRP5
Human Protein AtlasENSG00000171487-NLRP5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP59047   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP59047  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP59047
PhosPhoSitePlusP59047
Domaine pattern : Prosite (Expaxy)DAPIN (PS50824)    NACHT (PS50837)   
Domains : Interpro (EBI)DAPIN    DEATH-like_dom_sf    Leu-rich_rpt    LRR_dom_sf    NACHT_NTPase    NLRP_HD2    NOD2_WH    P-loop_NTPase   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    NACHT (PF05729)    NLRC4_HD2 (PF17776)    NOD2_WH (PF17779)    PYRIN (PF02758)   
Domain families : Pfam (NCBI)pfam13516    pfam05729    pfam17776    pfam17779    pfam02758   
Domain families : Smart (EMBL)PYRIN (SM01289)  
Conserved Domain (NCBI)NLRP5
SuperfamilyP59047
AlphaFold pdb e-kbP59047   
Human Protein Atlas [tissue]ENSG00000171487-NLRP5 [tissue]
HPRD10111
Protein Interaction databases
DIP (DOE-UCLA)P59047
IntAct (EBI)P59047
BioGRIDNLRP5
STRING (EMBL)NLRP5
ZODIACNLRP5
Ontologies - Pathways
QuickGOP59047
Ontology : AmiGOprotein binding  ATP binding  nucleus  nucleolus  cytoplasm  cytoplasm  mitochondrion  mitochondrion  Golgi apparatus  cell cortex  exocytosis  actin filament organization  tubulin binding  regulation of localization  positive regulation of embryonic development  establishment of spindle localization  regulation of cell division  establishment of organelle localization  cortical granule exocytosis  cortical granule  subcortical maternal complex  
Ontology : EGO-EBIprotein binding  ATP binding  nucleus  nucleolus  cytoplasm  cytoplasm  mitochondrion  mitochondrion  Golgi apparatus  cell cortex  exocytosis  actin filament organization  tubulin binding  regulation of localization  positive regulation of embryonic development  establishment of spindle localization  regulation of cell division  establishment of organelle localization  cortical granule exocytosis  cortical granule  subcortical maternal complex  
NDEx NetworkNLRP5
Atlas of Cancer Signalling NetworkNLRP5
Wikipedia pathwaysNLRP5
Orthology - Evolution
OrthoDB126206
GeneTree (enSembl)ENSG00000171487
Phylogenetic Trees/Animal Genes : TreeFamNLRP5
Homologs : HomoloGeneNLRP5
Homology/Alignments : Family Browser (UCSC)NLRP5
Gene fusions - Rearrangements
Fusion : QuiverNLRP5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRP5
dbVarNLRP5
ClinVarNLRP5
MonarchNLRP5
1000_GenomesNLRP5 
Exome Variant ServerNLRP5
GNOMAD BrowserENSG00000171487
Varsome BrowserNLRP5
ACMGNLRP5 variants
VarityP59047
Genomic Variants (DGV)NLRP5 [DGVbeta]
DECIPHERNLRP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRP5 
Mutations
ICGC Data PortalNLRP5 
TCGA Data PortalNLRP5 
Broad Tumor PortalNLRP5
OASIS PortalNLRP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRP5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNLRP5
Mutations and Diseases : HGMDNLRP5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNLRP5
DgiDB (Drug Gene Interaction Database)NLRP5
DoCM (Curated mutations)NLRP5
CIViC (Clinical Interpretations of Variants in Cancer)NLRP5
Cancer3DNLRP5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609658   
Orphanet
DisGeNETNLRP5
MedgenNLRP5
Genetic Testing Registry NLRP5
NextProtP59047 [Medical]
GENETestsNLRP5
Target ValidationNLRP5
Huge Navigator NLRP5 [HugePedia]
ClinGenNLRP5
Clinical trials, drugs, therapy
MyCancerGenomeNLRP5
Protein Interactions : CTDNLRP5
Pharm GKB GenePA162397970
PharosP59047
Clinical trialNLRP5
Miscellaneous
canSAR (ICR)NLRP5
HarmonizomeNLRP5
DataMed IndexNLRP5
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNLRP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:50 CEST 2021

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