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NLRP8 (NLR family pyrin domain containing 8)

Identity

Alias_namesNALP8
NACHT, leucine rich repeat and PYD containing 8
Alias_symbol (synonym)NOD16
PAN4
CLR19.2
Other alias
HGNC (Hugo) NLRP8
LocusID (NCBI) 126205
Atlas_Id 70879
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 55947832 and ends at 55988629 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NLRP8   22940
Cards
Entrez_Gene (NCBI)NLRP8  126205  NLR family pyrin domain containing 8
AliasesCLR19.2; NALP8; NOD16; PAN4
GeneCards (Weizmann)NLRP8
Ensembl hg19 (Hinxton)ENSG00000179709 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179709 [Gene_View]  chr19:55947832-55988629 [Contig_View]  NLRP8 [Vega]
ICGC DataPortalENSG00000179709
TCGA cBioPortalNLRP8
AceView (NCBI)NLRP8
Genatlas (Paris)NLRP8
WikiGenes126205
SOURCE (Princeton)NLRP8
Genetics Home Reference (NIH)NLRP8
Genomic and cartography
GoldenPath hg38 (UCSC)NLRP8  -     chr19:55947832-55988629 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NLRP8  -     19q13.43   [Description]    (hg19-Feb_2009)
EnsemblNLRP8 - 19q13.43 [CytoView hg19]  NLRP8 - 19q13.43 [CytoView hg38]
Mapping of homologs : NCBINLRP8 [Mapview hg19]  NLRP8 [Mapview hg38]
OMIM609659   
Gene and transcription
Genbank (Entrez)AY154463 BC148608 BC153174 BK001109
RefSeq transcript (Entrez)NM_001317000 NM_176811
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NLRP8
Cluster EST : UnigeneHs.446925 [ NCBI ]
CGAP (NCI)Hs.446925
Alternative Splicing GalleryENSG00000179709
Gene ExpressionNLRP8 [ NCBI-GEO ]   NLRP8 [ EBI - ARRAY_EXPRESS ]   NLRP8 [ SEEK ]   NLRP8 [ MEM ]
Gene Expression Viewer (FireBrowse)NLRP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)126205
GTEX Portal (Tissue expression)NLRP8
Human Protein AtlasENSG00000179709-NLRP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86W28   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86W28  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86W28
Splice isoforms : SwissVarQ86W28
PhosPhoSitePlusQ86W28
Domaine pattern : Prosite (Expaxy)DAPIN (PS50824)    NACHT (PS50837)   
Domains : Interpro (EBI)DAPIN    DEATH-like_dom    L_dom-like    Leu-rich_rpt    NACHT_NTPase    P-loop_NTPase   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    PYRIN (PF02758)   
Domain families : Pfam (NCBI)pfam13516    pfam02758   
Domain families : Smart (EMBL)PYRIN (SM01289)  
Conserved Domain (NCBI)NLRP8
DMDM Disease mutations126205
Blocks (Seattle)NLRP8
SuperfamilyQ86W28
Human Protein Atlas [tissue]ENSG00000179709-NLRP8 [tissue]
Peptide AtlasQ86W28
HPRD14807
IPIIPI00795887   IPI00219557   
Protein Interaction databases
DIP (DOE-UCLA)Q86W28
IntAct (EBI)Q86W28
FunCoupENSG00000179709
BioGRIDNLRP8
STRING (EMBL)NLRP8
ZODIACNLRP8
Ontologies - Pathways
QuickGOQ86W28
Ontology : AmiGOmolecular_function  ATP binding  cellular_component  cytoplasm  neuron death  
Ontology : EGO-EBImolecular_function  ATP binding  cellular_component  cytoplasm  neuron death  
NDEx NetworkNLRP8
Atlas of Cancer Signalling NetworkNLRP8
Wikipedia pathwaysNLRP8
Orthology - Evolution
OrthoDB126205
GeneTree (enSembl)ENSG00000179709
Phylogenetic Trees/Animal Genes : TreeFamNLRP8
HOVERGENQ86W28
HOGENOMQ86W28
Homologs : HomoloGeneNLRP8
Homology/Alignments : Family Browser (UCSC)NLRP8
Gene fusions - Rearrangements
Fusion: Tumor Portal NLRP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNLRP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NLRP8
dbVarNLRP8
ClinVarNLRP8
1000_GenomesNLRP8 
Exome Variant ServerNLRP8
ExAC (Exome Aggregation Consortium)ENSG00000179709
GNOMAD BrowserENSG00000179709
Genetic variants : HAPMAP126205
Genomic Variants (DGV)NLRP8 [DGVbeta]
DECIPHERNLRP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNLRP8 
Mutations
ICGC Data PortalNLRP8 
TCGA Data PortalNLRP8 
Broad Tumor PortalNLRP8
OASIS PortalNLRP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNLRP8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNLRP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NLRP8
DgiDB (Drug Gene Interaction Database)NLRP8
DoCM (Curated mutations)NLRP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NLRP8 (select a term)
intoGenNLRP8
Cancer3DNLRP8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609659   
Orphanet
MedgenNLRP8
Genetic Testing Registry NLRP8
NextProtQ86W28 [Medical]
TSGene126205
GENETestsNLRP8
Target ValidationNLRP8
Huge Navigator NLRP8 [HugePedia]
snp3D : Map Gene to Disease126205
BioCentury BCIQNLRP8
ClinGenNLRP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD126205
Chemical/Pharm GKB GenePA162398028
Clinical trialNLRP8
Miscellaneous
canSAR (ICR)NLRP8 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNLRP8
EVEXNLRP8
GoPubMedNLRP8
iHOPNLRP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:19:05 CET 2017

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