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NME4 (NME/NM23 nucleoside diphosphate kinase 4)

Identity

Alias_namesnon-metastatic cells 4
Alias_symbol (synonym)nm23-H4
NM23H4
NDPKD
Other aliasNDPK-D
HGNC (Hugo) NME4
LocusID (NCBI) 4833
Atlas_Id 41546
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 447192 and ends at 450754 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LOC100134368 (16p13.3) / NME4 (16p13.3)NME4 (16p13.3) / CALR (19p13.2)NME4 (16p13.3) / NCL (2q37.1)
THBS2 (6q27) / NME4 (16p13.3)THBS2 6q27 / NME4 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NME4   7852
Cards
Entrez_Gene (NCBI)NME4  4833  NME/NM23 nucleoside diphosphate kinase 4
AliasesNDPK-D; NM23H4; nm23-H4
GeneCards (Weizmann)NME4
Ensembl hg19 (Hinxton)ENSG00000103202 [Gene_View]  chr16:447192-450754 [Contig_View]  NME4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000103202 [Gene_View]  chr16:447192-450754 [Contig_View]  NME4 [Vega]
ICGC DataPortalENSG00000103202
TCGA cBioPortalNME4
AceView (NCBI)NME4
Genatlas (Paris)NME4
WikiGenes4833
SOURCE (Princeton)NME4
Genetics Home Reference (NIH)NME4
Genomic and cartography
GoldenPath hg19 (UCSC)NME4  -     chr16:447192-450754 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NME4  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblNME4 - 16p13.3 [CytoView hg19]  NME4 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBINME4 [Mapview hg19]  NME4 [Mapview hg38]
OMIM601818   
Gene and transcription
Genbank (Entrez)AF086133 AK094439 BC004880 BC017067 BE266496
RefSeq transcript (Entrez)NM_001286433 NM_001286435 NM_001286436 NM_001286438 NM_001286439 NM_001286440 NM_005009
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)NME4
Cluster EST : UnigeneHs.9235 [ NCBI ]
CGAP (NCI)Hs.9235
Alternative Splicing GalleryENSG00000103202
Gene ExpressionNME4 [ NCBI-GEO ]   NME4 [ EBI - ARRAY_EXPRESS ]   NME4 [ SEEK ]   NME4 [ MEM ]
Gene Expression Viewer (FireBrowse)NME4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4833
GTEX Portal (Tissue expression)NME4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00746   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00746  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00746
Splice isoforms : SwissVarO00746
Catalytic activity : Enzyme2.7.4.6 [ Enzyme-Expasy ]   2.7.4.62.7.4.6 [ IntEnz-EBI ]   2.7.4.6 [ BRENDA ]   2.7.4.6 [ KEGG ]   
PhosPhoSitePlusO00746
Domaine pattern : Prosite (Expaxy)NDP_KINASES (PS00469)   
Domains : Interpro (EBI)Nucleoside_diP_kinase    Nucleoside_diP_kinase_AS   
Domain families : Pfam (Sanger)NDK (PF00334)   
Domain families : Pfam (NCBI)pfam00334   
Domain families : Smart (EMBL)NDK (SM00562)  
Conserved Domain (NCBI)NME4
DMDM Disease mutations4833
Blocks (Seattle)NME4
PDB (SRS)1EHW   
PDB (PDBSum)1EHW   
PDB (IMB)1EHW   
PDB (RSDB)1EHW   
Structural Biology KnowledgeBase1EHW   
SCOP (Structural Classification of Proteins)1EHW   
CATH (Classification of proteins structures)1EHW   
SuperfamilyO00746
Human Protein AtlasENSG00000103202
Peptide AtlasO00746
HPRD03489
IPIIPI00012972   IPI00853152   IPI00658182   IPI00853259   IPI00876867   IPI00855746   IPI00855980   IPI00893883   
Protein Interaction databases
DIP (DOE-UCLA)O00746
IntAct (EBI)O00746
FunCoupENSG00000103202
BioGRIDNME4
STRING (EMBL)NME4
ZODIACNME4
Ontologies - Pathways
QuickGOO00746
Ontology : AmiGOnucleoside diphosphate kinase activity  protein binding  ATP binding  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  lipid transport  lipid binding  nucleoside metabolic process  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  regulation of apoptotic process  metal ion binding  
Ontology : EGO-EBInucleoside diphosphate kinase activity  protein binding  ATP binding  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  lipid transport  lipid binding  nucleoside metabolic process  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  regulation of apoptotic process  metal ion binding  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism   
NDEx NetworkNME4
Atlas of Cancer Signalling NetworkNME4
Wikipedia pathwaysNME4
Orthology - Evolution
OrthoDB4833
GeneTree (enSembl)ENSG00000103202
Phylogenetic Trees/Animal Genes : TreeFamNME4
HOVERGENO00746
HOGENOMO00746
Homologs : HomoloGeneNME4
Homology/Alignments : Family Browser (UCSC)NME4
Gene fusions - Rearrangements
Fusion : MitelmanTHBS2/NME4 [6q27/16p13.3]  [t(6;16)(q27;p13)]  
Fusion: TCGATHBS2 6q27 NME4 16p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNME4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NME4
dbVarNME4
ClinVarNME4
1000_GenomesNME4 
Exome Variant ServerNME4
ExAC (Exome Aggregation Consortium)NME4 (select the gene name)
Genetic variants : HAPMAP4833
Genomic Variants (DGV)NME4 [DGVbeta]
DECIPHER (Syndromes)16:447192-450754  ENSG00000103202
CONAN: Copy Number AnalysisNME4 
Mutations
ICGC Data PortalNME4 
TCGA Data PortalNME4 
Broad Tumor PortalNME4
OASIS PortalNME4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNME4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNME4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NME4
DgiDB (Drug Gene Interaction Database)NME4
DoCM (Curated mutations)NME4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NME4 (select a term)
intoGenNME4
Cancer3DNME4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601818   
Orphanet
MedgenNME4
Genetic Testing Registry NME4
NextProtO00746 [Medical]
TSGene4833
GENETestsNME4
Huge Navigator NME4 [HugePedia]
snp3D : Map Gene to Disease4833
BioCentury BCIQNME4
ClinGenNME4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4833
Chemical/Pharm GKB GenePA31657
Clinical trialNME4
Miscellaneous
canSAR (ICR)NME4 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNME4
EVEXNME4
GoPubMedNME4
iHOPNME4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:18:59 CET 2017

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