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NME8 (NME/NM23 family member 8)

Identity

Alias (NCBI)CILD6
DNAI8
HEL-S-99
NM23-H8
SPTRX2
TXNDC3
sptrx-2
HGNC (Hugo) NME8
HGNC Alias symbCILD6
SPTRX2
NM23-H8
HGNC Alias namesperm-specific thioredoxin 2
HGNC Previous nameTXNDC3
HGNC Previous namethioredoxin domain containing 3 (spermatozoa)
LocusID (NCBI) 51314
Atlas_Id 70886
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 37848597 and ends at 37900396 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NME8   16473
Cards
Entrez_Gene (NCBI)NME8    NME/NM23 family member 8
AliasesCILD6; DNAI8; HEL-S-99; NM23-H8; 
SPTRX2; TXNDC3; sptrx-2
GeneCards (Weizmann)NME8
Ensembl hg19 (Hinxton)ENSG00000086288 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086288 [Gene_View]  ENSG00000086288 [Sequence]  chr7:37848597-37900396 [Contig_View]  NME8 [Vega]
ICGC DataPortalENSG00000086288
TCGA cBioPortalNME8
AceView (NCBI)NME8
Genatlas (Paris)NME8
SOURCE (Princeton)NME8
Genetics Home Reference (NIH)NME8
Genomic and cartography
GoldenPath hg38 (UCSC)NME8  -     chr7:37848597-37900396 +  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NME8  -     7p14.1   [Description]    (hg19-Feb_2009)
GoldenPathNME8 - 7p14.1 [CytoView hg19]  NME8 - 7p14.1 [CytoView hg38]
ImmunoBaseENSG00000086288
Genome Data Viewer NCBINME8 [Mapview hg19]  
OMIM607421   610852   
Gene and transcription
Genbank (Entrez)AF202051 AF305596 AK313599 BC036816 GQ472221
RefSeq transcript (Entrez)NM_016616
Consensus coding sequences : CCDS (NCBI)NME8
Gene ExpressionNME8 [ NCBI-GEO ]   NME8 [ EBI - ARRAY_EXPRESS ]   NME8 [ SEEK ]   NME8 [ MEM ]
Gene Expression Viewer (FireBrowse)NME8 [ Firebrowse - Broad ]
GenevisibleExpression of NME8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51314
GTEX Portal (Tissue expression)NME8
Human Protein AtlasENSG00000086288-NME8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N427   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N427  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N427
PhosPhoSitePlusQ8N427
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)NDK-like_dom    NDK-like_dom_sf    Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)NDK (PF00334)    Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00334    pfam00085   
Domain families : Smart (EMBL)NDK (SM00562)  
Conserved Domain (NCBI)NME8
SuperfamilyQ8N427
AlphaFold pdb e-kbQ8N427   
Human Protein Atlas [tissue]ENSG00000086288-NME8 [tissue]
HPRD16243
Protein Interaction databases
DIP (DOE-UCLA)Q8N427
IntAct (EBI)Q8N427
BioGRIDNME8
STRING (EMBL)NME8
ZODIACNME8
Ontologies - Pathways
QuickGOQ8N427
Ontology : AmiGOnucleus  cytoplasm  cytoplasm  cytosol  axoneme  multicellular organism development  spermatogenesis  microtubule binding  nuclear speck  cell differentiation  flagellated sperm motility  cellular response to reactive oxygen species  outer dynein arm  cilium assembly  sperm midpiece  sperm principal piece  sperm cytoplasmic droplet  
Ontology : EGO-EBInucleus  cytoplasm  cytoplasm  cytosol  axoneme  multicellular organism development  spermatogenesis  microtubule binding  nuclear speck  cell differentiation  flagellated sperm motility  cellular response to reactive oxygen species  outer dynein arm  cilium assembly  sperm midpiece  sperm principal piece  sperm cytoplasmic droplet  
NDEx NetworkNME8
Atlas of Cancer Signalling NetworkNME8
Wikipedia pathwaysNME8
Orthology - Evolution
OrthoDB51314
GeneTree (enSembl)ENSG00000086288
Phylogenetic Trees/Animal Genes : TreeFamNME8
Homologs : HomoloGeneNME8
Homology/Alignments : Family Browser (UCSC)NME8
Gene fusions - Rearrangements
Fusion : QuiverNME8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNME8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NME8
dbVarNME8
ClinVarNME8
MonarchNME8
1000_GenomesNME8 
Exome Variant ServerNME8
GNOMAD BrowserENSG00000086288
Varsome BrowserNME8
ACMGNME8 variants
VarityQ8N427
Genomic Variants (DGV)NME8 [DGVbeta]
DECIPHERNME8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNME8 
Mutations
ICGC Data PortalNME8 
TCGA Data PortalNME8 
Broad Tumor PortalNME8
OASIS PortalNME8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNME8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNME8
Mutations and Diseases : HGMDNME8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNME8
DgiDB (Drug Gene Interaction Database)NME8
DoCM (Curated mutations)NME8
CIViC (Clinical Interpretations of Variants in Cancer)NME8
Cancer3DNME8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607421    610852   
Orphanet665   
DisGeNETNME8
MedgenNME8
Genetic Testing Registry NME8
NextProtQ8N427 [Medical]
GENETestsNME8
Target ValidationNME8
Huge Navigator NME8 [HugePedia]
ClinGenNME8
Clinical trials, drugs, therapy
MyCancerGenomeNME8
Protein Interactions : CTDNME8
Pharm GKB GenePA134925065
PharosQ8N427
Clinical trialNME8
Miscellaneous
canSAR (ICR)NME8
HarmonizomeNME8
DataMed IndexNME8
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNME8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:51 CEST 2021

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