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NMRK2 (nicotinamide riboside kinase 2)

Identity

Alias (NCBI)ITGB1BP3
MIBP
NRK2
HGNC (Hugo) NMRK2
HGNC Alias symbMIBP
NRK2
HGNC Alias namemuscle-specific beta 1 integrin binding protein
 nicotinamide riboside kinase 2
HGNC Previous nameITGB1BP3
HGNC Previous nameintegrin beta 1 binding protein 3
LocusID (NCBI) 27231
Atlas_Id 46766
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3933103 and ends at 3942416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MIER2 (19p13.3) / NMRK2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)NMRK2   17871
Cards
Entrez_Gene (NCBI)NMRK2    nicotinamide riboside kinase 2
AliasesITGB1BP3; MIBP; NRK2
GeneCards (Weizmann)NMRK2
Ensembl hg19 (Hinxton)ENSG00000077009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077009 [Gene_View]  ENSG00000077009 [Sequence]  chr19:3933103-3942416 [Contig_View]  NMRK2 [Vega]
ICGC DataPortalENSG00000077009
TCGA cBioPortalNMRK2
AceView (NCBI)NMRK2
Genatlas (Paris)NMRK2
SOURCE (Princeton)NMRK2
Genetics Home Reference (NIH)NMRK2
Genomic and cartography
GoldenPath hg38 (UCSC)NMRK2  -     chr19:3933103-3942416 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NMRK2  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathNMRK2 - 19p13.3 [CytoView hg19]  NMRK2 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000077009
genome Data Viewer NCBINMRK2 [Mapview hg19]  
OMIM608705   
Gene and transcription
Genbank (Entrez)AF190819 AK001663 AK022514 AL365377 AY611481
RefSeq transcript (Entrez)NM_001289117 NM_001375467 NM_001375468 NM_001375469 NM_014446 NM_170678
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NMRK2
Alternative Splicing GalleryENSG00000077009
Gene ExpressionNMRK2 [ NCBI-GEO ]   NMRK2 [ EBI - ARRAY_EXPRESS ]   NMRK2 [ SEEK ]   NMRK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NMRK2 [ Firebrowse - Broad ]
GenevisibleExpression of NMRK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27231
GTEX Portal (Tissue expression)NMRK2
Human Protein AtlasENSG00000077009-NMRK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPI5
Splice isoforms : SwissVarQ9NPI5
PhosPhoSitePlusQ9NPI5
Domains : Interpro (EBI)P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NMRK2
Blocks (Seattle)NMRK2
SuperfamilyQ9NPI5
Human Protein Atlas [tissue]ENSG00000077009-NMRK2 [tissue]
Peptide AtlasQ9NPI5
HPRD16371
IPIIPI00004401   IPI00009240   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPI5
IntAct (EBI)Q9NPI5
BioGRIDNMRK2
STRING (EMBL)NMRK2
ZODIACNMRK2
Ontologies - Pathways
QuickGOQ9NPI5
Ontology : AmiGOprotein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  NAD biosynthetic process  kinase activity  phosphorylation  NAD metabolic process  intracellular membrane-bounded organelle  negative regulation of myoblast differentiation  metal ion binding  ribosylnicotinamide kinase activity  ribosylnicotinate kinase activity  
Ontology : EGO-EBIprotein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  NAD biosynthetic process  kinase activity  phosphorylation  NAD metabolic process  intracellular membrane-bounded organelle  negative regulation of myoblast differentiation  metal ion binding  ribosylnicotinamide kinase activity  ribosylnicotinate kinase activity  
Pathways : KEGGNicotinate and nicotinamide metabolism   
NDEx NetworkNMRK2
Atlas of Cancer Signalling NetworkNMRK2
Wikipedia pathwaysNMRK2
Orthology - Evolution
OrthoDB27231
GeneTree (enSembl)ENSG00000077009
Phylogenetic Trees/Animal Genes : TreeFamNMRK2
HOGENOMQ9NPI5
Homologs : HomoloGeneNMRK2
Homology/Alignments : Family Browser (UCSC)NMRK2
Gene fusions - Rearrangements
Fusion : MitelmanMIER2/NMRK2 [19p13.3/19p13.3]  
Fusion : QuiverNMRK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNMRK2 [hg38]
dbVarNMRK2
ClinVarNMRK2
MonarchNMRK2
1000_GenomesNMRK2 
Exome Variant ServerNMRK2
GNOMAD BrowserENSG00000077009
Varsome BrowserNMRK2
Genomic Variants (DGV)NMRK2 [DGVbeta]
DECIPHERNMRK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNMRK2 
Mutations
ICGC Data PortalNMRK2 
TCGA Data PortalNMRK2 
Broad Tumor PortalNMRK2
OASIS PortalNMRK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNMRK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNMRK2
Mutations and Diseases : HGMDNMRK2
BioMutasearch NMRK2
DgiDB (Drug Gene Interaction Database)NMRK2
DoCM (Curated mutations)NMRK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NMRK2 (select a term)
intoGenNMRK2
Cancer3DNMRK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608705   
Orphanet
DisGeNETNMRK2
MedgenNMRK2
Genetic Testing Registry NMRK2
NextProtQ9NPI5 [Medical]
GENETestsNMRK2
Target ValidationNMRK2
Huge Navigator NMRK2 [HugePedia]
ClinGenNMRK2
Clinical trials, drugs, therapy
MyCancerGenomeNMRK2
Protein Interactions : CTD
Pharm GKB GenePA134938442
PharosQ9NPI5
Clinical trialNMRK2
Miscellaneous
canSAR (ICR)NMRK2 (select the gene name)
HarmonizomeNMRK2
DataMed IndexNMRK2
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNMRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:29:07 CET 2021
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