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NMRK2 (nicotinamide riboside kinase 2)

Identity

Alias_namesITGB1BP3
integrin beta 1 binding protein 3
Alias_symbol (synonym)MIBP
NRK2
Other alias
HGNC (Hugo) NMRK2
LocusID (NCBI) 27231
Atlas_Id 46766
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3933103 and ends at 3942416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MIER2 (19p13.3) / NMRK2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)NMRK2   17871
Cards
Entrez_Gene (NCBI)NMRK2  27231  nicotinamide riboside kinase 2
AliasesITGB1BP3; MIBP; NRK2
GeneCards (Weizmann)NMRK2
Ensembl hg19 (Hinxton)ENSG00000077009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077009 [Gene_View]  chr19:3933103-3942416 [Contig_View]  NMRK2 [Vega]
ICGC DataPortalENSG00000077009
TCGA cBioPortalNMRK2
AceView (NCBI)NMRK2
Genatlas (Paris)NMRK2
WikiGenes27231
SOURCE (Princeton)NMRK2
Genetics Home Reference (NIH)NMRK2
Genomic and cartography
GoldenPath hg38 (UCSC)NMRK2  -     chr19:3933103-3942416 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NMRK2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblNMRK2 - 19p13.3 [CytoView hg19]  NMRK2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBINMRK2 [Mapview hg19]  NMRK2 [Mapview hg38]
OMIM608705   
Gene and transcription
Genbank (Entrez)AF190819 AK001663 AK022514 AL365377 AY611481
RefSeq transcript (Entrez)NM_001289117 NM_014446 NM_170678
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NMRK2
Cluster EST : UnigeneHs.135458 [ NCBI ]
CGAP (NCI)Hs.135458
Alternative Splicing GalleryENSG00000077009
Gene ExpressionNMRK2 [ NCBI-GEO ]   NMRK2 [ EBI - ARRAY_EXPRESS ]   NMRK2 [ SEEK ]   NMRK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NMRK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27231
GTEX Portal (Tissue expression)NMRK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPI5
Splice isoforms : SwissVarQ9NPI5
PhosPhoSitePlusQ9NPI5
Domains : Interpro (EBI)P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NMRK2
DMDM Disease mutations27231
Blocks (Seattle)NMRK2
SuperfamilyQ9NPI5
Human Protein AtlasENSG00000077009
Peptide AtlasQ9NPI5
HPRD16371
IPIIPI00004401   IPI00009240   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPI5
IntAct (EBI)Q9NPI5
FunCoupENSG00000077009
BioGRIDNMRK2
STRING (EMBL)NMRK2
ZODIACNMRK2
Ontologies - Pathways
QuickGOQ9NPI5
Ontology : AmiGOprotein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  NAD biosynthetic process  phosphorylation  NAD metabolic process  intracellular membrane-bounded organelle  negative regulation of myoblast differentiation  metal ion binding  ribosylnicotinamide kinase activity  ribosylnicotinate kinase activity  
Ontology : EGO-EBIprotein binding  ATP binding  nucleoplasm  cytosol  plasma membrane  NAD biosynthetic process  phosphorylation  NAD metabolic process  intracellular membrane-bounded organelle  negative regulation of myoblast differentiation  metal ion binding  ribosylnicotinamide kinase activity  ribosylnicotinate kinase activity  
Pathways : KEGGNicotinate and nicotinamide metabolism   
NDEx NetworkNMRK2
Atlas of Cancer Signalling NetworkNMRK2
Wikipedia pathwaysNMRK2
Orthology - Evolution
OrthoDB27231
GeneTree (enSembl)ENSG00000077009
Phylogenetic Trees/Animal Genes : TreeFamNMRK2
HOVERGENQ9NPI5
HOGENOMQ9NPI5
Homologs : HomoloGeneNMRK2
Homology/Alignments : Family Browser (UCSC)NMRK2
Gene fusions - Rearrangements
Fusion : MitelmanMIER2/NMRK2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNMRK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NMRK2
dbVarNMRK2
ClinVarNMRK2
1000_GenomesNMRK2 
Exome Variant ServerNMRK2
ExAC (Exome Aggregation Consortium)NMRK2 (select the gene name)
Genetic variants : HAPMAP27231
Genomic Variants (DGV)NMRK2 [DGVbeta]
DECIPHERNMRK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNMRK2 
Mutations
ICGC Data PortalNMRK2 
TCGA Data PortalNMRK2 
Broad Tumor PortalNMRK2
OASIS PortalNMRK2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNMRK2
BioMutasearch NMRK2
DgiDB (Drug Gene Interaction Database)NMRK2
DoCM (Curated mutations)NMRK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NMRK2 (select a term)
intoGenNMRK2
Cancer3DNMRK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608705   
Orphanet
MedgenNMRK2
Genetic Testing Registry NMRK2
NextProtQ9NPI5 [Medical]
TSGene27231
GENETestsNMRK2
Huge Navigator NMRK2 [HugePedia]
snp3D : Map Gene to Disease27231
BioCentury BCIQNMRK2
ClinGenNMRK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27231
Chemical/Pharm GKB GenePA134938442
Clinical trialNMRK2
Miscellaneous
canSAR (ICR)NMRK2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNMRK2
EVEXNMRK2
GoPubMedNMRK2
iHOPNMRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:28:51 CEST 2017

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