NOB1 (NIN1 (RPN12) binding protein 1 homolog)

2012-03-01  

Identity

HGNC
NOB1
LOCATION
16q22.1
LOCUSID
28987
ALIAS
ART-4,MST158,MSTP158,NOB1P,PSMD8BP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28987
MIM: 613586
HGNC: 29540
Ensembl: ENSG00000141101

Variants:

dbSNP: 28987
ClinVar: 28987
TCGA: ENSG00000141101
COSMIC: NOB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141101ENST00000268802Q9ULX3
ENSG00000141101ENST00000564620H3BUR4
ENSG00000141101ENST00000569871H3BUR4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
291155742018Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma.27
275058622016MiR-139-3p induces cell apoptosis and inhibits metastasis of cervical cancer by targeting NOB1.25
277332142017miR-326 Inhibits Gastric Cancer Cell Growth Through Downregulating NOB1.22
212872982012RNAi-mediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells.15
257600582015MicroRNA-326 functions as a tumor suppressor in colorectal cancer by targeting the nin one binding protein.14
267436882016MiR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein.10
161729192005Cloning, expression and characterization of the human NOB1 gene.9
288492322017Inhibition of NOB1 by microRNA-330-5p overexpression represses cell growth of non-small cell lung cancer.9
242280912013Expression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma.7
251697422014Knockdown of NOB1 expression inhibits the malignant transformation of human prostate cancer cells.7

Citation

Dessen P

NOB1 (NIN1 (RPN12) binding protein 1 homolog)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52654/nob1