NOC2L (NOC2 like nucleolar associated transcriptional repressor)

2003-05-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
NET15,NET7,NIR,PPP1R112
FUSION GENES

Other Information

Locus ID:

NCBI: 26155
MIM: 610770
HGNC: 24517
Ensembl: ENSG00000188976

Variants:

dbSNP: 26155
ClinVar: 26155
TCGA: ENSG00000188976
COSMIC: NOC2L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188976ENST00000327044Q9Y3T9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209594622011Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.25
163225612005NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.23
223637082012Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.4

Citation

Dessen P

NOC2L (NOC2 like nucleolar associated transcriptional repressor)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40316/noc2l