Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NOD1 (nucleotide binding oligomerization domain containing 1)

Identity

Alias_namesCARD4
caspase recruitment domain family
Alias_symbol (synonym)NLRC1
CLR7.1
Other alias
HGNC (Hugo) NOD1
LocusID (NCBI) 10392
Atlas_Id 912
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 30424527 and ends at 30478866 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NOD1 (7p14.3) / NOD1 (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NOD1   16390
Cards
Entrez_Gene (NCBI)NOD1  10392  nucleotide binding oligomerization domain containing 1
AliasesCARD4; CLR7.1; NLRC1
GeneCards (Weizmann)NOD1
Ensembl hg19 (Hinxton)ENSG00000106100 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106100 [Gene_View]  chr7:30424527-30478866 [Contig_View]  NOD1 [Vega]
ICGC DataPortalENSG00000106100
TCGA cBioPortalNOD1
AceView (NCBI)NOD1
Genatlas (Paris)NOD1
WikiGenes10392
SOURCE (Princeton)NOD1
Genetics Home Reference (NIH)NOD1
Genomic and cartography
GoldenPath hg38 (UCSC)NOD1  -     chr7:30424527-30478866 -  7p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOD1  -     7p14.3   [Description]    (hg19-Feb_2009)
EnsemblNOD1 - 7p14.3 [CytoView hg19]  NOD1 - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBINOD1 [Mapview hg19]  NOD1 [Mapview hg38]
OMIM605980   
Gene and transcription
Genbank (Entrez)AA845215 AF113925 AF126484 AK023969 AK300367
RefSeq transcript (Entrez)NM_001354849 NM_006092
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOD1
Cluster EST : UnigeneHs.738731 [ NCBI ]
CGAP (NCI)Hs.738731
Alternative Splicing GalleryENSG00000106100
Gene ExpressionNOD1 [ NCBI-GEO ]   NOD1 [ EBI - ARRAY_EXPRESS ]   NOD1 [ SEEK ]   NOD1 [ MEM ]
Gene Expression Viewer (FireBrowse)NOD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10392
GTEX Portal (Tissue expression)NOD1
Human Protein AtlasENSG00000106100-NOD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y239   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y239  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y239
Splice isoforms : SwissVarQ9Y239
PhosPhoSitePlusQ9Y239
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    NACHT (PS50837)   
Domains : Interpro (EBI)CARD    DEATH-like_dom    L_dom-like    Leu-rich_rpt    NACHT_NTPase    P-loop_NTPase   
Domain families : Pfam (Sanger)CARD (PF00619)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam00619    pfam13516   
Conserved Domain (NCBI)NOD1
DMDM Disease mutations10392
Blocks (Seattle)NOD1
PDB (SRS)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB (PDBSum)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB (IMB)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB (RSDB)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
Structural Biology KnowledgeBase2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
SCOP (Structural Classification of Proteins)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
CATH (Classification of proteins structures)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
SuperfamilyQ9Y239
Human Protein Atlas [tissue]ENSG00000106100-NOD1 [tissue]
Peptide AtlasQ9Y239
HPRD05815
IPIIPI00005776   IPI00910180   IPI00916706   IPI00917279   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y239
IntAct (EBI)Q9Y239
FunCoupENSG00000106100
BioGRIDNOD1
STRING (EMBL)NOD1
ZODIACNOD1
Ontologies - Pathways
QuickGOQ9Y239
Ontology : AmiGOactivation of MAPK activity  positive regulation of dendritic cell antigen processing and presentation  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  defense response  inflammatory response  signal transduction  JNK cascade  cysteine-type endopeptidase activator activity involved in apoptotic process  detection of biotic stimulus  detection of bacterium  basolateral plasma membrane  apical plasma membrane  protein deubiquitination  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  intracellular signal transduction  interleukin-8 biosynthetic process  defense response to bacterium  identical protein binding  identical protein binding  protein homodimerization activity  peptidoglycan binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  positive regulation of JNK cascade  CARD domain binding  defense response to Gram-positive bacterium  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  cellular response to muramyl dipeptide  positive regulation of NIK/NF-kappaB signaling  positive regulation of xenophagy  
Ontology : EGO-EBIactivation of MAPK activity  positive regulation of dendritic cell antigen processing and presentation  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  defense response  inflammatory response  signal transduction  JNK cascade  cysteine-type endopeptidase activator activity involved in apoptotic process  detection of biotic stimulus  detection of bacterium  basolateral plasma membrane  apical plasma membrane  protein deubiquitination  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  intracellular signal transduction  interleukin-8 biosynthetic process  defense response to bacterium  identical protein binding  identical protein binding  protein homodimerization activity  peptidoglycan binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  positive regulation of JNK cascade  CARD domain binding  defense response to Gram-positive bacterium  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  cellular response to muramyl dipeptide  positive regulation of NIK/NF-kappaB signaling  positive regulation of xenophagy  
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkNOD1
Atlas of Cancer Signalling NetworkNOD1
Wikipedia pathwaysNOD1
Orthology - Evolution
OrthoDB10392
GeneTree (enSembl)ENSG00000106100
Phylogenetic Trees/Animal Genes : TreeFamNOD1
HOVERGENQ9Y239
HOGENOMQ9Y239
Homologs : HomoloGeneNOD1
Homology/Alignments : Family Browser (UCSC)NOD1
Gene fusions - Rearrangements
Fusion : QuiverNOD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOD1
dbVarNOD1
ClinVarNOD1
1000_GenomesNOD1 
Exome Variant ServerNOD1
ExAC (Exome Aggregation Consortium)ENSG00000106100
GNOMAD BrowserENSG00000106100
Genetic variants : HAPMAP10392
Genomic Variants (DGV)NOD1 [DGVbeta]
DECIPHERNOD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOD1 
Mutations
ICGC Data PortalNOD1 
TCGA Data PortalNOD1 
Broad Tumor PortalNOD1
OASIS PortalNOD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOD1
DgiDB (Drug Gene Interaction Database)NOD1
DoCM (Curated mutations)NOD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOD1 (select a term)
intoGenNOD1
Cancer3DNOD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605980   
Orphanet
DisGeNETNOD1
MedgenNOD1
Genetic Testing Registry NOD1
NextProtQ9Y239 [Medical]
TSGene10392
GENETestsNOD1
Target ValidationNOD1
Huge Navigator NOD1 [HugePedia]
snp3D : Map Gene to Disease10392
BioCentury BCIQNOD1
ClinGenNOD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10392
Chemical/Pharm GKB GenePA162398098
Clinical trialNOD1
Miscellaneous
canSAR (ICR)NOD1 (select the gene name)
Probes
Litterature
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOD1
EVEXNOD1
GoPubMedNOD1
iHOPNOD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon May 14 12:06:13 CEST 2018
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