Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NOD1 (nucleotide binding oligomerization domain containing 1)

Identity

Alias (NCBI)CARD4
CLR7.1
NLRC1
HGNC (Hugo) NOD1
HGNC Alias symbNLRC1
CLR7.1
HGNC Alias namenucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
 NLR family, CARD domain containing 1
HGNC Previous nameCARD4
HGNC Previous namecaspase recruitment domain family, member 4
LocusID (NCBI) 10392
Atlas_Id 912
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 30424527 and ends at 30478784 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NOD1 (7p14.3)::NOD1 (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)NOD1   16390
Cards
Entrez_Gene (NCBI)NOD1    nucleotide binding oligomerization domain containing 1
AliasesCARD4; CLR7.1; NLRC1
GeneCards (Weizmann)NOD1
Ensembl hg19 (Hinxton)ENSG00000106100 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106100 [Gene_View]  ENSG00000106100 [Sequence]  chr7:30424527-30478784 [Contig_View]  NOD1 [Vega]
ICGC DataPortalENSG00000106100
TCGA cBioPortalNOD1
AceView (NCBI)NOD1
Genatlas (Paris)NOD1
SOURCE (Princeton)NOD1
Genetics Home Reference (NIH)NOD1
Genomic and cartography
GoldenPath hg38 (UCSC)NOD1  -     chr7:30424527-30478784 -  7p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOD1  -     7p14.3   [Description]    (hg19-Feb_2009)
GoldenPathNOD1 - 7p14.3 [CytoView hg19]  NOD1 - 7p14.3 [CytoView hg38]
ImmunoBaseENSG00000106100
Genome Data Viewer NCBINOD1 [Mapview hg19]  
OMIM605980   
Gene and transcription
Genbank (Entrez)AA845215 AF113925 AF126484 AK023969 AK300367
RefSeq transcript (Entrez)NM_001354849 NM_006092
Consensus coding sequences : CCDS (NCBI)NOD1
Gene ExpressionNOD1 [ NCBI-GEO ]   NOD1 [ EBI - ARRAY_EXPRESS ]   NOD1 [ SEEK ]   NOD1 [ MEM ]
Gene Expression Viewer (FireBrowse)NOD1 [ Firebrowse - Broad ]
GenevisibleExpression of NOD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10392
GTEX Portal (Tissue expression)NOD1
Human Protein AtlasENSG00000106100-NOD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y239   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y239  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y239
PhosPhoSitePlusQ9Y239
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    NACHT (PS50837)   
Domains : Interpro (EBI)CARD    DEATH-like_dom_sf    Leu-rich_rpt    LRR_dom_sf    NACHT_NTPase    NLRP_HD2    NOD2_WH   
Domain families : Pfam (Sanger)CARD (PF00619)    LRR_6 (PF13516)    NACHT (PF05729)    NLRC4_HD2 (PF17776)    NOD2_WH (PF17779)   
Domain families : Pfam (NCBI)pfam00619    pfam13516    pfam05729    pfam17776    pfam17779   
Conserved Domain (NCBI)NOD1
PDB (RSDB)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB Europe2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB (PDBSum)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
PDB (IMB)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
Structural Biology KnowledgeBase2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
SCOP (Structural Classification of Proteins)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
CATH (Classification of proteins structures)2B1W    2DBD    2NSN    2NZ7    4E9M    4JQW   
SuperfamilyQ9Y239
AlphaFold pdb e-kbQ9Y239   
Human Protein Atlas [tissue]ENSG00000106100-NOD1 [tissue]
HPRD05815
Protein Interaction databases
DIP (DOE-UCLA)Q9Y239
IntAct (EBI)Q9Y239
BioGRIDNOD1
STRING (EMBL)NOD1
ZODIACNOD1
Ontologies - Pathways
QuickGOQ9Y239
Ontology : AmiGOpattern recognition receptor signaling pathway  positive regulation of dendritic cell antigen processing and presentation  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  defense response  inflammatory response  signal transduction  cysteine-type endopeptidase activator activity involved in apoptotic process  detection of biotic stimulus  positive regulation of cell death  detection of bacterium  basolateral plasma membrane  apical plasma membrane  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  intracellular signal transduction  intracellular signal transduction  pattern recognition receptor activity  defense response to bacterium  identical protein binding  identical protein binding  protein homodimerization activity  peptidoglycan binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  protein-containing complex binding  innate immune response  phagocytic vesicle  positive regulation of JNK cascade  anchored component of plasma membrane  CARD domain binding  defense response to Gram-positive bacterium  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  cellular response to muramyl dipeptide  positive regulation of NIK/NF-kappaB signaling  positive regulation of xenophagy  
Ontology : EGO-EBIpattern recognition receptor signaling pathway  positive regulation of dendritic cell antigen processing and presentation  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  defense response  inflammatory response  signal transduction  cysteine-type endopeptidase activator activity involved in apoptotic process  detection of biotic stimulus  positive regulation of cell death  detection of bacterium  basolateral plasma membrane  apical plasma membrane  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  intracellular signal transduction  intracellular signal transduction  pattern recognition receptor activity  defense response to bacterium  identical protein binding  identical protein binding  protein homodimerization activity  peptidoglycan binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  protein-containing complex binding  innate immune response  phagocytic vesicle  positive regulation of JNK cascade  anchored component of plasma membrane  CARD domain binding  defense response to Gram-positive bacterium  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of ERK1 and ERK2 cascade  cellular response to muramyl dipeptide  positive regulation of NIK/NF-kappaB signaling  positive regulation of xenophagy  
Pathways : KEGGKEGG_NOD_LIKE_RECEPTOR_SIGNALING    KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION   
NDEx NetworkNOD1
Atlas of Cancer Signalling NetworkNOD1
Wikipedia pathwaysNOD1
Orthology - Evolution
OrthoDB10392
GeneTree (enSembl)ENSG00000106100
Phylogenetic Trees/Animal Genes : TreeFamNOD1
Homologs : HomoloGeneNOD1
Homology/Alignments : Family Browser (UCSC)NOD1
Gene fusions - Rearrangements
Fusion : QuiverNOD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOD1
dbVarNOD1
ClinVarNOD1
MonarchNOD1
1000_GenomesNOD1 
Exome Variant ServerNOD1
GNOMAD BrowserENSG00000106100
Varsome BrowserNOD1
ACMGNOD1 variants
VarityQ9Y239
Genomic Variants (DGV)NOD1 [DGVbeta]
DECIPHERNOD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOD1 
Mutations
ICGC Data PortalNOD1 
TCGA Data PortalNOD1 
Broad Tumor PortalNOD1
OASIS PortalNOD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOD1
Mutations and Diseases : HGMDNOD1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNOD1
DgiDB (Drug Gene Interaction Database)NOD1
DoCM (Curated mutations)NOD1
CIViC (Clinical Interpretations of Variants in Cancer)NOD1
Cancer3DNOD1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605980   
Orphanet
DisGeNETNOD1
MedgenNOD1
Genetic Testing Registry NOD1
NextProtQ9Y239 [Medical]
GENETestsNOD1
Target ValidationNOD1
Huge Navigator NOD1 [HugePedia]
ClinGenNOD1
Clinical trials, drugs, therapy
MyCancerGenomeNOD1
Protein Interactions : CTDNOD1
Pharm GKB GenePA162398098
PharosQ9Y239
Clinical trialNOD1
Miscellaneous
canSAR (ICR)NOD1
HarmonizomeNOD1
ARCHS4NOD1
DataMed IndexNOD1
Probes
Litterature
PubMed235 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNOD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:49:42 CET 2022
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