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NOD2 (nucleotide-binding oligomerization domain containing 2)

Identity

Other namesACUG
BLAU
CARD15
CD
CLR16.3
IBD1
NLRC2
NOD2B
PSORAS1
HGNC (Hugo) NOD2
LocusID (NCBI) 64127
Location 16q12.1
Location_base_pair Starts at 50731050 and ends at 50766987 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NOD2   5331
Cards
Entrez_Gene (NCBI)NOD2  64127  nucleotide-binding oligomerization domain containing 2
GeneCards (Weizmann)NOD2
Ensembl (Hinxton)ENSG00000167207 [Gene_View]  chr16:50731050-50766987 [Contig_View]  NOD2 [Vega]
AceView (NCBI)NOD2
Genatlas (Paris)NOD2
WikiGenes64127
SOURCE (Princeton)NM_022162
Genomic and cartography
GoldenPath (UCSC)NOD2  -  16q12.1   chr16:50731050-50766987 +  16q12.1   [Description]    (hg19-Feb_2009)
EnsemblNOD2 - 16q12.1 [CytoView]
Mapping of homologs : NCBINOD2 [Mapview]
OMIM181000   186580   266600   605956   607507   609464   
Gene and transcription
Genbank (Entrez)AF178930 AK298099 AY187233 AY187234 AY187235
RefSeq transcript (Entrez)NM_022162
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_007508 NT_010498 NW_001838288 NW_004929402
Consensus coding sequences : CCDS (NCBI)NOD2
Cluster EST : UnigeneHs.592072 [ NCBI ]
CGAP (NCI)Hs.592072
Alternative Splicing : Fast-db (Paris)GSHG0011182
Alternative Splicing GalleryENSG00000167207
Gene ExpressionNOD2 [ NCBI-GEO ]     NOD2 [ SEEK ]   NOD2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC29 (Uniprot)
NextProtQ9HC29  [Medical]
With graphics : InterProQ9HC29
Splice isoforms : SwissVarQ9HC29 (Swissvar)
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    LRR (PS51450)    NACHT (PS50837)   
Domains : Interpro (EBI)CARD    DEATH-like_dom    Leu-rich_rpt    NACHT_NTPase    P-loop_NTPase   
Related proteins : CluSTrQ9HC29
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Domain families : Smart (EMBL)CARD (SM00114)  
DMDM Disease mutations64127
Blocks (Seattle)Q9HC29
Human Protein AtlasENSG00000167207
Peptide AtlasQ9HC29
HPRD05810
IPIIPI00005559   IPI00759531   IPI00910731   IPI00980493   IPI00977404   IPI00978366   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC29
IntAct (EBI)Q9HC29
FunCoupENSG00000167207
BioGRIDNOD2
InParanoidQ9HC29
Interologous Interaction database Q9HC29
IntegromeDBNOD2
STRING (EMBL)NOD2
Ontologies - Pathways
Ontology : AmiGOactivation of MAPK activity  toll-like receptor signaling pathway  innate immune response in mucosa  microglial cell activation involved in immune response  cytokine production involved in immune response  immunoglobulin production involved in immunoglobulin mediated immune response  positive regulation of dendritic cell antigen processing and presentation  negative regulation of T cell mediated immunity  positive regulation of dendritic cell cytokine production  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  positive regulation of type 2 immune response  negative regulation of inflammatory response to antigenic stimulus  positive regulation of humoral immune response mediated by circulating immunoglobulin  protein binding  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  defense response  positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  JNK cascade  response to nutrient  COP9 signalosome  detection of biotic stimulus  cell surface  detection of bacterium  enzyme binding  protein kinase binding  vesicle  negative regulation of NF-kappaB transcription factor activity  response to muramyl dipeptide  response to lipopolysaccharide  detection of muramyl dipeptide  muramyl dipeptide binding  negative regulation of interferon-gamma production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-2 production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  positive regulation of stress-activated MAPK cascade  toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  activation of MAPK activity involved in innate immune response  intracellular signal transduction  TRIF-dependent toll-like receptor signaling pathway  nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  defense response to bacterium  peptidoglycan binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  positive regulation of phosphatidylinositol 3-kinase activity  negative regulation of growth of symbiont in host  innate immune response  innate immune response  innate immune response  positive regulation of Notch signaling pathway  positive regulation of JNK cascade  positive regulation of gamma-delta T cell activation  positive regulation of epithelial cell proliferation  CARD domain binding  positive regulation of interleukin-1 beta secretion  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  defense response to Gram-positive bacterium  positive regulation of B cell activation  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  positive regulation of oxidoreductase activity  stress-activated MAPK cascade  positive regulation of nitric-oxide synthase biosynthetic process  pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response  positive regulation of prostaglandin-endoperoxide synthase activity  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to peptidoglycan  macrophage inflammatory protein-1 alpha production  regulation of neutrophil chemotaxis  negative regulation of macrophage apoptotic process  positive regulation of prostaglandin-E synthase activity  
Ontology : EGO-EBIactivation of MAPK activity  toll-like receptor signaling pathway  innate immune response in mucosa  microglial cell activation involved in immune response  cytokine production involved in immune response  immunoglobulin production involved in immunoglobulin mediated immune response  positive regulation of dendritic cell antigen processing and presentation  negative regulation of T cell mediated immunity  positive regulation of dendritic cell cytokine production  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  positive regulation of type 2 immune response  negative regulation of inflammatory response to antigenic stimulus  positive regulation of humoral immune response mediated by circulating immunoglobulin  protein binding  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  defense response  positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  JNK cascade  response to nutrient  COP9 signalosome  detection of biotic stimulus  cell surface  detection of bacterium  enzyme binding  protein kinase binding  vesicle  negative regulation of NF-kappaB transcription factor activity  response to muramyl dipeptide  response to lipopolysaccharide  detection of muramyl dipeptide  muramyl dipeptide binding  negative regulation of interferon-gamma production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-2 production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-17 production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  positive regulation of stress-activated MAPK cascade  toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  activation of MAPK activity involved in innate immune response  intracellular signal transduction  TRIF-dependent toll-like receptor signaling pathway  nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  defense response to bacterium  peptidoglycan binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  positive regulation of phosphatidylinositol 3-kinase activity  negative regulation of growth of symbiont in host  innate immune response  innate immune response  innate immune response  positive regulation of Notch signaling pathway  positive regulation of JNK cascade  positive regulation of gamma-delta T cell activation  positive regulation of epithelial cell proliferation  CARD domain binding  positive regulation of interleukin-1 beta secretion  regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  defense response to Gram-positive bacterium  positive regulation of B cell activation  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein oligomerization  positive regulation of oxidoreductase activity  stress-activated MAPK cascade  positive regulation of nitric-oxide synthase biosynthetic process  pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response  positive regulation of prostaglandin-endoperoxide synthase activity  positive regulation of ERK1 and ERK2 cascade  nucleotide-binding oligomerization domain containing signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to peptidoglycan  macrophage inflammatory protein-1 alpha production  regulation of neutrophil chemotaxis  negative regulation of macrophage apoptotic process  positive regulation of prostaglandin-E synthase activity  
Pathways : KEGGNOD-like receptor signaling pathway    TNF signaling pathway    Shigellosis    Tuberculosis    Inflammatory bowel disease (IBD)   
REACTOMENOD2
Protein Interaction DatabaseNOD2
Wikipedia pathwaysNOD2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NOD2
SNP (GeneSNP Utah)NOD2
SNP : HGBaseNOD2
Genetic variants : HAPMAPNOD2
1000_GenomesNOD2 
ICGC programENSG00000167207 
Somatic Mutations in Cancer : COSMICNOD2 
CONAN: Copy Number AnalysisNOD2 
Mutations and Diseases : HGMDNOD2
OMIM181000    186580    266600    605956    607507    609464   
GENETestsNOD2
Disease Genetic AssociationNOD2
Huge Navigator NOD2 [HugePedia]  NOD2 [HugeCancerGEM]
Genomic VariantsNOD2  NOD2 [DGVbeta]
Exome VariantNOD2
dbVarNOD2
ClinVarNOD2
snp3D : Map Gene to Disease64127
General knowledge
Homologs : HomoloGeneNOD2
Homology/Alignments : Family Browser (UCSC)NOD2
Phylogenetic Trees/Animal Genes : TreeFamNOD2
Chemical/Protein Interactions : CTD64127
Chemical/Pharm GKB GenePA26074
Clinical trialNOD2
Cancer Resource (Charite)ENSG00000167207
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineNOD2
iHOPNOD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:29:54 CEST 2014

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