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NODAL (nodal growth differentiation factor)

Identity

Alias (NCBI)HTX5
HGNC (Hugo) NODAL
HGNC Previous namenodal, mouse, homolog
 nodal homolog (mouse)
LocusID (NCBI) 4838
Atlas_Id 47626
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70431936 and ends at 70441681 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC20 (10q22.1) / NODAL (10q22.1)LRRC20 10q22.1 / NODAL 10q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)NODAL   7865
Cards
Entrez_Gene (NCBI)NODAL    nodal growth differentiation factor
AliasesHTX5
GeneCards (Weizmann)NODAL
Ensembl hg19 (Hinxton)ENSG00000156574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156574 [Gene_View]  ENSG00000156574 [Sequence]  chr10:70431936-70441681 [Contig_View]  NODAL [Vega]
ICGC DataPortalENSG00000156574
TCGA cBioPortalNODAL
AceView (NCBI)NODAL
Genatlas (Paris)NODAL
SOURCE (Princeton)NODAL
Genetics Home Reference (NIH)NODAL
Genomic and cartography
GoldenPath hg38 (UCSC)NODAL  -     chr10:70431936-70441681 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NODAL  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathNODAL - 10q22.1 [CytoView hg19]  NODAL - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000156574
Genome Data Viewer NCBINODAL [Mapview hg19]  
OMIM270100   601265   
Gene and transcription
Genbank (Entrez)AI670948 BC033585 BC039861 BC104976 BC112025
RefSeq transcript (Entrez)NM_001329906 NM_018055
Consensus coding sequences : CCDS (NCBI)NODAL
Gene ExpressionNODAL [ NCBI-GEO ]   NODAL [ EBI - ARRAY_EXPRESS ]   NODAL [ SEEK ]   NODAL [ MEM ]
Gene Expression Viewer (FireBrowse)NODAL [ Firebrowse - Broad ]
GenevisibleExpression of NODAL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4838
GTEX Portal (Tissue expression)NODAL
Human Protein AtlasENSG00000156574-NODAL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S42   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S42  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S42
PhosPhoSitePlusQ96S42
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)NODAL
PDB (RSDB)4N1D   
PDB Europe4N1D   
PDB (PDBSum)4N1D   
PDB (IMB)4N1D   
Structural Biology KnowledgeBase4N1D   
SCOP (Structural Classification of Proteins)4N1D   
CATH (Classification of proteins structures)4N1D   
SuperfamilyQ96S42
AlphaFold pdb e-kbQ96S42   
Human Protein Atlas [tissue]ENSG00000156574-NODAL [tissue]
HPRD08370
Protein Interaction databases
DIP (DOE-UCLA)Q96S42
IntAct (EBI)Q96S42
BioGRIDNODAL
STRING (EMBL)NODAL
ZODIACNODAL
Ontologies - Pathways
QuickGOQ96S42
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  trophectodermal cellular morphogenesis  neural fold formation  liver development  placenta development  embryonic placenta development  maternal placenta development  vasculature development  heart looping  inhibition of neuroepithelial cell differentiation  cytokine activity  protein binding  extracellular space  extracellular space  brain development  growth factor activity  embryonic pattern specification  polarity specification of proximal/distal axis  regulation of gastrulation  positive regulation of vascular endothelial growth factor production  negative regulation of cell development  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  morphogen activity  stem cell population maintenance  positive regulation of cell-cell adhesion  BMP signaling pathway  positive regulation of activin receptor signaling pathway  floor plate morphogenesis  endodermal cell differentiation  cell migration involved in gastrulation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of angiogenesis  positive regulation of transcription by RNA polymerase II  axial mesodermal cell fate specification  mesendoderm development  digestive tract morphogenesis  embryonic cranial skeleton morphogenesis  formation of anatomical boundary  positive regulation of epithelial cell proliferation  positive regulation of DNA-binding transcription factor activity  embryonic process involved in female pregnancy  maternal process involved in parturition  positive regulation of SMAD protein signal transduction  SMAD protein signal transduction  left lung morphogenesis  negative regulation of androgen receptor signaling pathway  epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  positive regulation of ERK1 and ERK2 cascade  type I activin receptor binding  type I activin receptor binding  transforming growth factor beta receptor signaling pathway involved in primitive streak formation  nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of trophoblast cell migration  negative regulation of chorionic trophoblast cell proliferation  regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  trophectodermal cellular morphogenesis  neural fold formation  liver development  placenta development  embryonic placenta development  maternal placenta development  vasculature development  heart looping  inhibition of neuroepithelial cell differentiation  cytokine activity  protein binding  extracellular space  extracellular space  brain development  growth factor activity  embryonic pattern specification  polarity specification of proximal/distal axis  regulation of gastrulation  positive regulation of vascular endothelial growth factor production  negative regulation of cell development  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  morphogen activity  stem cell population maintenance  positive regulation of cell-cell adhesion  BMP signaling pathway  positive regulation of activin receptor signaling pathway  floor plate morphogenesis  endodermal cell differentiation  cell migration involved in gastrulation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of angiogenesis  positive regulation of transcription by RNA polymerase II  axial mesodermal cell fate specification  mesendoderm development  digestive tract morphogenesis  embryonic cranial skeleton morphogenesis  formation of anatomical boundary  positive regulation of epithelial cell proliferation  positive regulation of DNA-binding transcription factor activity  embryonic process involved in female pregnancy  maternal process involved in parturition  positive regulation of SMAD protein signal transduction  SMAD protein signal transduction  left lung morphogenesis  negative regulation of androgen receptor signaling pathway  epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  positive regulation of ERK1 and ERK2 cascade  type I activin receptor binding  type I activin receptor binding  transforming growth factor beta receptor signaling pathway involved in primitive streak formation  nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of trophoblast cell migration  negative regulation of chorionic trophoblast cell proliferation  regulation of stem cell population maintenance  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkNODAL
Atlas of Cancer Signalling NetworkNODAL
Wikipedia pathwaysNODAL
Orthology - Evolution
OrthoDB4838
GeneTree (enSembl)ENSG00000156574
Phylogenetic Trees/Animal Genes : TreeFamNODAL
Homologs : HomoloGeneNODAL
Homology/Alignments : Family Browser (UCSC)NODAL
Gene fusions - Rearrangements
Fusion : MitelmanLRRC20/NODAL [10q22.1/10q22.1]  
Fusion : QuiverNODAL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNODAL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NODAL
dbVarNODAL
ClinVarNODAL
MonarchNODAL
1000_GenomesNODAL 
Exome Variant ServerNODAL
GNOMAD BrowserENSG00000156574
Varsome BrowserNODAL
ACMGNODAL variants
VarityQ96S42
Genomic Variants (DGV)NODAL [DGVbeta]
DECIPHERNODAL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNODAL 
Mutations
ICGC Data PortalNODAL 
TCGA Data PortalNODAL 
Broad Tumor PortalNODAL
OASIS PortalNODAL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNODAL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNODAL
Mutations and Diseases : HGMDNODAL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNODAL
DgiDB (Drug Gene Interaction Database)NODAL
DoCM (Curated mutations)NODAL
CIViC (Clinical Interpretations of Variants in Cancer)NODAL
Cancer3DNODAL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM270100    601265   
Orphanet17142    20436    20435    18904    12486    12484    12485    14774   
DisGeNETNODAL
MedgenNODAL
Genetic Testing Registry NODAL
NextProtQ96S42 [Medical]
GENETestsNODAL
Target ValidationNODAL
Huge Navigator NODAL [HugePedia]
ClinGenNODAL (curated)
Clinical trials, drugs, therapy
MyCancerGenomeNODAL
Protein Interactions : CTDNODAL
Pharm GKB GenePA31669
PharosQ96S42
Clinical trialNODAL
Miscellaneous
canSAR (ICR)NODAL
HarmonizomeNODAL
DataMed IndexNODAL
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNODAL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:01 CEST 2021
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