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NODAL (nodal growth differentiation factor)

Identity

Alias_namesnodal, mouse, homolog
nodal homolog (mouse)
Other aliasHTX5
HGNC (Hugo) NODAL
LocusID (NCBI) 4838
Atlas_Id 47626
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70431936 and ends at 70441709 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC20 (10q22.1) / NODAL (10q22.1)LRRC20 10q22.1 / NODAL 10q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q22;q22) LRRC20/NODAL

External links

Nomenclature
HGNC (Hugo)NODAL   7865
Cards
Entrez_Gene (NCBI)NODAL  4838  nodal growth differentiation factor
AliasesHTX5
GeneCards (Weizmann)NODAL
Ensembl hg19 (Hinxton)ENSG00000156574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156574 [Gene_View]  chr10:70431936-70441709 [Contig_View]  NODAL [Vega]
ICGC DataPortalENSG00000156574
TCGA cBioPortalNODAL
AceView (NCBI)NODAL
Genatlas (Paris)NODAL
WikiGenes4838
SOURCE (Princeton)NODAL
Genetics Home Reference (NIH)NODAL
Genomic and cartography
GoldenPath hg38 (UCSC)NODAL  -     chr10:70431936-70441709 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NODAL  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblNODAL - 10q22.1 [CytoView hg19]  NODAL - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBINODAL [Mapview hg19]  NODAL [Mapview hg38]
OMIM270100   601265   
Gene and transcription
Genbank (Entrez)AI670948 BC033585 BC039861 BC104976 BC112025
RefSeq transcript (Entrez)NM_001329906 NM_018055
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NODAL
Cluster EST : UnigeneHs.370414 [ NCBI ]
CGAP (NCI)Hs.370414
Alternative Splicing GalleryENSG00000156574
Gene ExpressionNODAL [ NCBI-GEO ]   NODAL [ EBI - ARRAY_EXPRESS ]   NODAL [ SEEK ]   NODAL [ MEM ]
Gene Expression Viewer (FireBrowse)NODAL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4838
GTEX Portal (Tissue expression)NODAL
Human Protein AtlasENSG00000156574-NODAL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S42   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S42  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S42
Splice isoforms : SwissVarQ96S42
PhosPhoSitePlusQ96S42
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)NODAL
DMDM Disease mutations4838
Blocks (Seattle)NODAL
PDB (SRS)4N1D   
PDB (PDBSum)4N1D   
PDB (IMB)4N1D   
PDB (RSDB)4N1D   
Structural Biology KnowledgeBase4N1D   
SCOP (Structural Classification of Proteins)4N1D   
CATH (Classification of proteins structures)4N1D   
SuperfamilyQ96S42
Human Protein Atlas [tissue]ENSG00000156574-NODAL [tissue]
Peptide AtlasQ96S42
HPRD08370
IPIIPI00045497   IPI00301401   IPI00641371   
Protein Interaction databases
DIP (DOE-UCLA)Q96S42
IntAct (EBI)Q96S42
FunCoupENSG00000156574
BioGRIDNODAL
STRING (EMBL)NODAL
ZODIACNODAL
Ontologies - Pathways
QuickGOQ96S42
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  trophectodermal cellular morphogenesis  neural fold formation  liver development  placenta development  embryonic placenta development  maternal placenta development  vasculature development  heart looping  inhibition of neuroepithelial cell differentiation  cytokine activity  transforming growth factor beta receptor binding  extracellular space  brain development  growth factor activity  embryonic pattern specification  polarity specification of proximal/distal axis  regulation of receptor activity  regulation of gastrulation  positive regulation of vascular endothelial growth factor production  negative regulation of cell development  positive regulation of pathway-restricted SMAD protein phosphorylation  morphogen activity  stem cell population maintenance  positive regulation of cell-cell adhesion  BMP signaling pathway  positive regulation of activin receptor signaling pathway  floor plate morphogenesis  endodermal cell differentiation  cell migration involved in gastrulation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of angiogenesis  positive regulation of transcription by RNA polymerase II  axial mesodermal cell fate specification  mesendoderm development  cell development  digestive tract morphogenesis  embryonic cranial skeleton morphogenesis  formation of anatomical boundary  positive regulation of epithelial cell proliferation  positive regulation of DNA binding transcription factor activity  embryonic process involved in female pregnancy  maternal process involved in parturition  positive regulation of SMAD protein import into nucleus  SMAD protein signal transduction  left lung morphogenesis  negative regulation of androgen receptor signaling pathway  epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  positive regulation of ERK1 and ERK2 cascade  type I activin receptor binding  transforming growth factor beta receptor signaling pathway involved in primitive streak formation  nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of trophoblast cell migration  negative regulation of chorionic trophoblast cell proliferation  regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  trophectodermal cellular morphogenesis  neural fold formation  liver development  placenta development  embryonic placenta development  maternal placenta development  vasculature development  heart looping  inhibition of neuroepithelial cell differentiation  cytokine activity  transforming growth factor beta receptor binding  extracellular space  brain development  growth factor activity  embryonic pattern specification  polarity specification of proximal/distal axis  regulation of receptor activity  regulation of gastrulation  positive regulation of vascular endothelial growth factor production  negative regulation of cell development  positive regulation of pathway-restricted SMAD protein phosphorylation  morphogen activity  stem cell population maintenance  positive regulation of cell-cell adhesion  BMP signaling pathway  positive regulation of activin receptor signaling pathway  floor plate morphogenesis  endodermal cell differentiation  cell migration involved in gastrulation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of angiogenesis  positive regulation of transcription by RNA polymerase II  axial mesodermal cell fate specification  mesendoderm development  cell development  digestive tract morphogenesis  embryonic cranial skeleton morphogenesis  formation of anatomical boundary  positive regulation of epithelial cell proliferation  positive regulation of DNA binding transcription factor activity  embryonic process involved in female pregnancy  maternal process involved in parturition  positive regulation of SMAD protein import into nucleus  SMAD protein signal transduction  left lung morphogenesis  negative regulation of androgen receptor signaling pathway  epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  positive regulation of ERK1 and ERK2 cascade  type I activin receptor binding  transforming growth factor beta receptor signaling pathway involved in primitive streak formation  nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of trophoblast cell migration  negative regulation of chorionic trophoblast cell proliferation  regulation of stem cell population maintenance  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkNODAL
Atlas of Cancer Signalling NetworkNODAL
Wikipedia pathwaysNODAL
Orthology - Evolution
OrthoDB4838
GeneTree (enSembl)ENSG00000156574
Phylogenetic Trees/Animal Genes : TreeFamNODAL
HOVERGENQ96S42
HOGENOMQ96S42
Homologs : HomoloGeneNODAL
Homology/Alignments : Family Browser (UCSC)NODAL
Gene fusions - Rearrangements
Fusion : MitelmanLRRC20/NODAL [10q22.1/10q22.1]  [t(10;10)(q22;q22)]  
Fusion: TCGA_MDACCLRRC20 10q22.1 NODAL 10q22.1 BRCA
Fusion PortalLRRC20 10q22.1 NODAL 10q22.1 BRCA
Fusion : QuiverNODAL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNODAL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NODAL
dbVarNODAL
ClinVarNODAL
1000_GenomesNODAL 
Exome Variant ServerNODAL
ExAC (Exome Aggregation Consortium)ENSG00000156574
GNOMAD BrowserENSG00000156574
Genetic variants : HAPMAP4838
Genomic Variants (DGV)NODAL [DGVbeta]
DECIPHERNODAL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNODAL 
Mutations
ICGC Data PortalNODAL 
TCGA Data PortalNODAL 
Broad Tumor PortalNODAL
OASIS PortalNODAL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNODAL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNODAL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NODAL
DgiDB (Drug Gene Interaction Database)NODAL
DoCM (Curated mutations)NODAL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NODAL (select a term)
intoGenNODAL
Cancer3DNODAL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM270100    601265   
Orphanet17142    20436    20435    18904    12486    12484    12485    14774   
DisGeNETNODAL
MedgenNODAL
Genetic Testing Registry NODAL
NextProtQ96S42 [Medical]
TSGene4838
GENETestsNODAL
Target ValidationNODAL
Huge Navigator NODAL [HugePedia]
snp3D : Map Gene to Disease4838
BioCentury BCIQNODAL
ClinGenNODAL (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4838
Chemical/Pharm GKB GenePA31669
Clinical trialNODAL
Miscellaneous
canSAR (ICR)NODAL (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNODAL
EVEXNODAL
GoPubMedNODAL
iHOPNODAL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:28:02 CET 2018
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