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NOP2 (NOP2 nucleolar protein)

Identity

Alias_namesmember 1
NOL1
Alias_symbol (synonym)NOP120
NSUN1
p120
Other alias
HGNC (Hugo) NOP2
LocusID (NCBI) 4839
Atlas_Id 53027
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6666036 and ends at 6677498 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHD4 (12p13.31) / NOP2 (12p13.31)MARS (12q13.3) / NOP2 (12p13.31)NOP2 (12p13.31) / SNRPN (15q11.2)
NOP2 (12p13.31) / TCF3 (19p13.3)NOP2 (12p13.31) / TCF7L1 (2p11.2)TCF3 (19p13.3) / NOP2 (12p13.31)
MARS 12q13.3 / NOP2 12p13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOP2   7867
Cards
Entrez_Gene (NCBI)NOP2  4839  NOP2 nucleolar protein
AliasesNOL1; NOP120; NSUN1; p120
GeneCards (Weizmann)NOP2
Ensembl hg19 (Hinxton)ENSG00000111641 [Gene_View]  chr12:6666036-6677498 [Contig_View]  NOP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111641 [Gene_View]  chr12:6666036-6677498 [Contig_View]  NOP2 [Vega]
ICGC DataPortalENSG00000111641
TCGA cBioPortalNOP2
AceView (NCBI)NOP2
Genatlas (Paris)NOP2
WikiGenes4839
SOURCE (Princeton)NOP2
Genetics Home Reference (NIH)NOP2
Genomic and cartography
GoldenPath hg19 (UCSC)NOP2  -     chr12:6666036-6677498 -  12p13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NOP2  -     12p13.31   [Description]    (hg38-Dec_2013)
EnsemblNOP2 - 12p13.31 [CytoView hg19]  NOP2 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBINOP2 [Mapview hg19]  NOP2 [Mapview hg38]
OMIM164031   
Gene and transcription
Genbank (Entrez)AK056208 AK129852 AK307582 AU131299 BC000656
RefSeq transcript (Entrez)NM_001033714 NM_001258308 NM_001258309 NM_001258310 NM_006170
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)NOP2
Cluster EST : UnigeneHs.534334 [ NCBI ]
CGAP (NCI)Hs.534334
Alternative Splicing GalleryENSG00000111641
Gene ExpressionNOP2 [ NCBI-GEO ]   NOP2 [ EBI - ARRAY_EXPRESS ]   NOP2 [ SEEK ]   NOP2 [ MEM ]
Gene Expression Viewer (FireBrowse)NOP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4839
GTEX Portal (Tissue expression)NOP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46087   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46087  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46087
Splice isoforms : SwissVarP46087
PhosPhoSitePlusP46087
Domaine pattern : Prosite (Expaxy)NOL1_NOP2_SUN (PS01153)    SAM_MT_RSMB_NOP (PS51686)   
Domains : Interpro (EBI)Fmu/NOL1/Nop2p_CS    Methyltr_RsmF_N    MeTrfase_RsmB/NOP2    Nop2p    P120R_rpt    RCMT    RCMT_NOP2    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltr_RsmF_N (PF17125)    Nol1_Nop2_Fmu (PF01189)    P120R (PF08062)   
Domain families : Pfam (NCBI)pfam17125    pfam01189    pfam08062   
Conserved Domain (NCBI)NOP2
DMDM Disease mutations4839
Blocks (Seattle)NOP2
SuperfamilyP46087
Human Protein AtlasENSG00000111641
Peptide AtlasP46087
HPRD01244
IPIIPI00294891   IPI00872909   IPI00654555   IPI00797590   IPI01011199   IPI01009814   IPI01010255   IPI01009533   IPI01009991   IPI01015572   
Protein Interaction databases
DIP (DOE-UCLA)P46087
IntAct (EBI)P46087
FunCoupENSG00000111641
BioGRIDNOP2
STRING (EMBL)NOP2
ZODIACNOP2
Ontologies - Pathways
QuickGOP46087
Ontology : AmiGOprotein binding  nucleolus  rRNA processing  positive regulation of cell proliferation  S-adenosylmethionine-dependent methyltransferase activity  methylation  poly(A) RNA binding  
Ontology : EGO-EBIprotein binding  nucleolus  rRNA processing  positive regulation of cell proliferation  S-adenosylmethionine-dependent methyltransferase activity  methylation  poly(A) RNA binding  
NDEx NetworkNOP2
Atlas of Cancer Signalling NetworkNOP2
Wikipedia pathwaysNOP2
Orthology - Evolution
OrthoDB4839
GeneTree (enSembl)ENSG00000111641
Phylogenetic Trees/Animal Genes : TreeFamNOP2
HOVERGENP46087
HOGENOMP46087
Homologs : HomoloGeneNOP2
Homology/Alignments : Family Browser (UCSC)NOP2
Gene fusions - Rearrangements
Fusion : MitelmanMARS/NOP2 [12q13.3/12p13.31]  [t(12;12)(p13;q13)]  
Fusion : MitelmanNOP2/TCF3 [12p13.31/19p13.3]  [t(12;19)(p13;p13)]  
Fusion: TCGAMARS 12q13.3 NOP2 12p13.31 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOP2
dbVarNOP2
ClinVarNOP2
1000_GenomesNOP2 
Exome Variant ServerNOP2
ExAC (Exome Aggregation Consortium)NOP2 (select the gene name)
Genetic variants : HAPMAP4839
Genomic Variants (DGV)NOP2 [DGVbeta]
DECIPHER (Syndromes)12:6666036-6677498  ENSG00000111641
CONAN: Copy Number AnalysisNOP2 
Mutations
ICGC Data PortalNOP2 
TCGA Data PortalNOP2 
Broad Tumor PortalNOP2
OASIS PortalNOP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOP2
DgiDB (Drug Gene Interaction Database)NOP2
DoCM (Curated mutations)NOP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOP2 (select a term)
intoGenNOP2
Cancer3DNOP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164031   
Orphanet
MedgenNOP2
Genetic Testing Registry NOP2
NextProtP46087 [Medical]
TSGene4839
GENETestsNOP2
Huge Navigator NOP2 [HugePedia]
snp3D : Map Gene to Disease4839
BioCentury BCIQNOP2
ClinGenNOP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4839
Chemical/Pharm GKB GenePA164724026
Clinical trialNOP2
Miscellaneous
canSAR (ICR)NOP2 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOP2
EVEXNOP2
GoPubMedNOP2
iHOPNOP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:29 CEST 2017

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