NOS3 (nitric oxide synthase 3)

2003-08-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
ECNOS,eNOS
FUSION GENES

Other Information

Locus ID:

NCBI: 4846
MIM: 163729
HGNC: 7876
Ensembl: ENSG00000164867

Variants:

dbSNP: 4846
ClinVar: 4846
TCGA: ENSG00000164867
COSMIC: NOS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164867ENST00000297494P29474
ENSG00000164867ENST00000461406E7ESA7
ENSG00000164867ENST00000467517P29474
ENSG00000164867ENST00000475017H7C4V4
ENSG00000164867ENST00000484524P29474

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Calcium signaling pathwayKEGGko04020
VEGF signaling pathwayKEGGko04370
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Calcium signaling pathwayKEGGhsa04020
VEGF signaling pathwayKEGGhsa04370
Metabolic pathwaysKEGGhsa01100
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
eNOS activationREACTOMER-HSA-203615
NOSIP mediated eNOS traffickingREACTOMER-HSA-203754
NOSTRIN mediated eNOS traffickingREACTOMER-HSA-203641
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationREACTOMER-HSA-1474151
Insulin resistanceKEGGhsa04931
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD19671875, 25545243, 29938344
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD19671875, 25545243
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD19671875, 25545243
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD22890915
PA151249535diureticsChemicalClinicalAnnotationassociatedPD22543981
PA164712308Ace Inhibitors, PlainChemicalClinicalAnnotationassociatedPD22543981
PA164712372Angiotensin II AntagonistsChemicalClinicalAnnotationassociatedPD22543981
PA164712445AntihypertensivesChemicalClinicalAnnotationassociatedPD
PA164712446Antihypertensives And Diuretics In CombinationChemicalClinicalAnnotationassociatedPD19704415
PA164712535Beta Blocking AgentsChemicalClinicalAnnotationassociatedPD22543981, 22890915
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD19671875, 25545243
PA166128370salvianolic acid bChemicalClinicalAnnotationassociatedPD24827774
PA24684AKT1GenePathwayassociated20124951
PA24685AKT2GenePathwayassociated20124951
PA24686AKT3GenePathwayassociated20124951
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD19671875, 29938344
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD22890915
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD24827774
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD22543981
PA444447Carcinoma, HepatocellularDiseaseClinicalAnnotationassociatedPD27058899
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD22706620
PA444606Erectile DysfunctionDiseaseClinicalAnnotationassociatedPD22064666
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotationassociatedPD24684492
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD19671875, 25545243
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD19671875, 25545243
PA445742Stomach NeoplasmsDiseaseClinicalAnnotationassociatedPD19671875, 25545243
PA448478l-arginineChemicalMultilinkAnnotationassociated26385052
PA448497aspirinChemicalClinicalAnnotationassociatedPD22890915
PA449053clopidogrelChemicalClinicalAnnotationassociatedPD22890915
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD19671875, 25545243, 29938344
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD24684492
PA449319digoxinChemicalClinicalAnnotationassociatedPD22543981
PA449412doxorubicinChemicalClinicalAnnotation, PathwayassociatedPD19671875, 21048526, 25545243, 29938344
PA449456enalaprilChemicalClinicalAnnotationassociatedPD22706620
PA449476epirubicinChemicalClinicalAnnotationassociatedPD19671875, 25545243
PA449957ibuprofenChemicalPathwayassociated25502615
PA450428methotrexateChemicalClinicalAnnotationassociatedPD19671875, 25545243, 29938344
PA451346sildenafilChemicalClinicalAnnotationassociatedPD22064666
PA451483spironolactoneChemicalClinicalAnnotationassociatedPD22543981
PA7000sorafenibChemicalClinicalAnnotationassociatedPD27058899

References

Pubmed IDYearTitleCitations
217010702011Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.154
146567312004Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.133
163688812006Red blood cells express a functional endothelial nitric oxide synthase.130
173274342007Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.125
122349442002Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells.124
194878142009Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.117
201537222010MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity.114
124467672002Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.109
233930102013H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.108
231086562012Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase.106

Citation

Dessen P

NOS3 (nitric oxide synthase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41554/nos3