NOSTRIN (nitric oxide synthase trafficking)

2004-04-01  

Identity

HGNC
NOSTRIN
LOCATION
2q24.3
LOCUSID
115677
ALIAS
DaIP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 115677
MIM: 607496
HGNC: 20203
Ensembl: ENSG00000163072

Variants:

dbSNP: 115677
ClinVar: 115677
TCGA: ENSG00000163072
COSMIC: NOSTRIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163072ENST00000317647Q8IVI9
ENSG00000163072ENST00000397206Q8IVI9
ENSG00000163072ENST00000397209Q8IVI9
ENSG00000163072ENST00000427068H7BZA6
ENSG00000163072ENST00000439509F8WCW8
ENSG00000163072ENST00000444448Q8IVI9
ENSG00000163072ENST00000445023Q8IVI9
ENSG00000163072ENST00000447264E9PDM0
ENSG00000163072ENST00000458381Q8IVI9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
NOSTRIN mediated eNOS traffickingREACTOMER-HSA-203641

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
124468462002NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase.37
204427442010Linkage and candidate gene studies of autism spectrum disorders in European populations.24
168073572006Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN.23
162343282005NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.20
274012512016Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer.15
211837352011Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression.14
189806132009NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation.4
245882012015The relation of maternal serum eNOS, NOSTRIN and ADMA levels with aetiopathogenesis of preeclampsia and/or intrauterine fetal growth restriction.3

Citation

Dessen P

NOSTRIN (nitric oxide synthase trafficking)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41555/nostrin