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NOTCH2 (Notch homolog 2 (Drosophila))

Written2008-03Anna Bigas, Lluis Espinosa
Instituto de Investigación Biomédica de Bellvitge, IDIBELL, Barcelona, Spain

(Note : for Links provided by Atlas : click)

Identity

Other namesAGS2
hN2
HGNC (Hugo) NOTCH2
LocusID (NCBI) 4853
Atlas_Id 41556
Location 1p12  [Link to chromosome band 1p12]
Location_base_pair Starts at 120477736 and ends at 120612317 bp from pter ( according to hg19-Feb_2009)  [Mapping NOTCH2.png]
Fusion genes
(updated 2016)
ARID5B (10q21.2) / NOTCH2 (1p12)ATP1A1 (1p13.1) / NOTCH2 (1p12)DNAJC11 (1p36.31) / NOTCH2 (1p12)
MAGI3 (1p13.2) / NOTCH2 (1p12)NOTCH2 (1p12) / CD59 (11p13)NOTCH2 (1p12) / CEP128 (14q31.1)
NOTCH2 (1p12) / MNDA (1q23.1)NOTCH2 (1p12) / PSMA5 (1p13.3)NOTCH2 (1p12) / SLC44A1 (9q31.1)
NOTCH2 (1p12) / SPAG17 (1p12)NOTCH2 (1p12) / YWHAZ (8q22.3)PTGFRN (1p13.1) / NOTCH2 (1p12)
SEC22B (1q21.1) / NOTCH2 (1p12)SSR1 (6p24.3) / NOTCH2 (1p12)TMBIM6 (12q13.12) / NOTCH2 (1p12)

DNA/RNA

 
Description 34 exons
Transcription 7860 bp

Protein

 
  A. : 2472 AA, 265.4 KD.
LNR: Lin/Notch repeats (light blue); TM: transmembrane; OPA: glutamine-rich region; PEST sequence
Dark blue: Epidermal Growth Factor repeats
Light red: ankyrin repeats
Dark red: Nuclear localization signal
B. : Notch activation diagram
Description This gene encodes a member of the Notch family. Members of this family are Type1 transmembrane receptors and share structural characteristics represented in the diagram. The conserved domains include 36 EGF repeats and 3 lin/Notch Repeats (LNR) in the extracellular domain, 7 Ankyrin repeats, 2 different nuclear localization domains and 1 OPA/PEST region conform the intracellular domain.
The Notch2 gene is transcribed and translated as a single inactive protein. This protein is cleaved by a furin-like convertase in the trans-golgi network before it reaches the plasma membrane to yield an active form. Cleavage results in a C-terminal fragment and a N-terminal fragment, linked by disulfide bridges. Following ligand binding, it is first cleaved by ADAM17 metallopeptidase to yield a membrane-associated intermediate fragment. This fragment is then cleaved by presenilin dependent gamma-secretase to release a Notch-derived peptide containing the intracellular domain from the membrane (see Notch activation diagram).
Protein modifications:
  • Phosphorylation: Different phosphorylation processes are important for regulating Notch2 activity. Only GSK3beta has been found to phosphorylate Notch2 in 32D-myeloid cells.
  • Glycosylation: fringe glycosyl-transferases modify the extracellular domain of Notch2 by glycosylation.
  • Expression Expressed in the brain, heart, kidney, spleen (hematopoietic cells,T-cells, B-cells and mast cells), lung, intestine, skeletal muscle and liver (hepatic cells and bile duct cells), ameloblasts.
    Localisation Type I membrane protein. Following proteolytical processing it is translocated to the nucleus.
    Function Physiological receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation, Notch intracellular domain forms a transcriptional activator complex with RBP-j kappa and Mastermind proteins and activates genes of the hairy/enhancer of split (hes) family. Notch2 behaves very similar to Notch1 at the biochemical level, and in fact, C-terminal intracellular region of Notch1 can functionally replace that of Notch2 in vivo. However specific functions, specific expression patterns and embryonic lethality of single mutant mice indicate that both proteins are not redundant.
    Biological functions strictly associated to Notch2 are:
  • Development of kidney (proximal nephron structures: podocytes and proximal convoluted tubules).
  • B-cell differentiation: involved in the final stages of B-cell maturation at the marginal zone of the spleen and expression of CD23 in B-CLL (B-Cell Chronic Lymphoblastic leukaemia).
  • T-cell maturation: later stages of T cell development, induction of CD8+ cells.
  • Notch2 is also required for formation of the placental circulatory system.
  • Homology Degree of amino acid identity between Notch1 and Notch2 proteins: overall, 56%; EGF-like repeats, 58%; LNR,58%; CDC10, 76% and PEST, 79%.

    Mutations

    Germinal Two different mutations segregating in two families affected by Alagille syndrome: One mutation results in partial deletion of the intracellular domain including 4 ankyrin repeats, the second mutation affects EGF repeat 11.

    Implicated in

    Note
    Entity Alagille syndrome (AGS)
    Disease Alagille syndrome (AGS) is a dominant multisystem disorder defined clinically by bile duct paucity and cholestasis in association with cardiac, skeletal and ophthalmologic manifestations with less-frequent clinical involvement of renal and vascular systems. 94% of affected individuals have mutations in the Jagged1 gene.
    Oncogenesis Notch2 intracellular domain (active Notch2) has neoplastic transformation capacities.
      
    Entity B-Cell Chronic Lymphoblastic Leukemia (B-CLL).
    Oncogenesis Function: upregulation of CD23, which has been correlated with high cell viability and inhibition of apoptosis in B-CLL.
      
    Entity Embryonal brain tumors, medulloblastoma
    Prognosis Target gene hes1 expression correlates with shorter patient survival.
    Oncogenesis Loss of heterozygosity of Notch2 results in positive survival of Oligodendrioma and glioblastoma.
    Amplification in 15% of 40 analyzed embryonal brain tumors.
      
    Entity Melanoma
    Oncogenesis Amplification of 1p12 in melanoma cell lines
      
    Entity Lung carcinoma
    Oncogenesis Amplification in 9 of 12 samples of squamous lung carcinoma.
      
    Entity Breast carcinoma
    Oncogenesis Putative role of Notch2 as tumor suppressor since upregulation of its expression is associated with survival, and activated Notch2 induces apoptosis in breast cancer xenografts.
      

    Bibliography

    Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines.
    Bigas A, Martin DI, Milner LA.
    Mol Cell Biol. 1998 Apr;18(4):2324-33.
    PMID 9528802
     
    Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors.
    Boulay JL, Miserez AR, Zweifel C, Sivasankaran B, Kana V, Ghaffari A, Luyken C, Sabel M, Zerrouqi A, Wasner M, Van Meir E, Tolnay M, Reifenberger G, Merlo A.
    PLoS ONE. 2007 Jun 27;2(6):e576.
    PMID 17593975
     
    Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.
    Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM.
    Mol Cell Biol. 1997 Nov;17(11):6265-73.
    PMID 9343387
     
    Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.
    Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R.
    Development. 2007 Feb;134(4):801-11.
    PMID 17229764
     
    Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways.
    Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A.
    J Biol Chem. 2003 Aug 22;278(34):32227-35.
    PMID 12794074
     
    Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
    Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, Brat DJ, Perry A, Eberhart CG.
    Cancer Res. 2004 Nov 1;64(21):7787-93.
    PMID 15520184
     
    Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis.
    Garnis C, Campbell J, Davies JJ, Macaulay C, Lam S, Lam WL.
    Hum Mol Genet. 2005 Feb 15;14(4):475-82.
    PMID 15615770
     
    Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta.
    Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman JR, Tanaka S.
    Differentiation. 2007 Mar;75(3):268-78.
    PMID 17359302
     
    Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.
    Hamada Y, Kadokawa Y, Okabe M, Ikawa M, Coleman JR, Tsujimoto Y.
    Development. 1999 Aug;126(15):3415-24.
    PMID 10393120
     
    Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia.
    Hubmann R, Schwarzmeier JD, Shehata M, Hilgarth M, Duechler M, Dettke M, Berger R.
    Blood. 2002 May 15;99(10):3742-7.
    PMID 11986231
     
    Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.
    Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S.
    J Immunol. 2007 Jul 1;179(1):195-200.
    PMID 17579038
     
    Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth.
    O’Neill CF, Urs S, Cinelli C, Lincoln A, Nadeau RJ, León R, Toher J, Mouta-Bellum C, Friesel RE, Liaw L.
    Am J Pathol. 2007 Sep;171(3):1023-36.
    PMID 17675579
     
    Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.
    Pan Y, Liu Z, Shen J, Kopan R.
    Dev Biol. 2005 Oct 15;286(2):472-82.
    PMID 16169548
     
    The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer.
    Parr C, Watkins G, Jiang WG.
    Int J Mol Med. 2004 Nov;14(5):779-86.
    PMID 15492845
     
    Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
    Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H.
    Immunity. 2003 May;18(5):675-85.
    PMID 12753744
     
    Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
    Saxena MT, Schroeter EH, Mumm JS, Kopan R.
    J Biol Chem. 2001 Oct 26;276(43):40268-73.
    PMID 11518718
     
    Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.
    Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H.
    J Biol Chem. 2001 Jul 13;276(28):25753-8.
    PMID 11346656
     
    Notch2: a second mammalian Notch gene.
    Weinmaster G, Roberts VJ, Lemke G.
    Development. 1992 Dec;116(4):931-41.
    PMID 1295745
     
    Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.
    Witt CM, Hurez V, Swindle CS, Hamada Y, Klug CA.
    Mol Cell Biol. 2003 Dec;23(23):8637-50.
    PMID 14612407
     
    The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
    Wu L, Maillard I, Nakamura M, Pear WS, Griffin JD.
    Blood. 2007 Nov 15;110(10):3618-23.
    PMID 17699740
     

    Citation

    This paper should be referenced as such :
    Bigas, A ; Espinosa, L
    NOTCH2 (Notch homolog 2 (Drosophila))
    Atlas Genet Cytogenet Oncol Haematol. 2009;13(1):20-23.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/NOTCH2ID41556ch1p12.html


    Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
      Alagille syndrome (AGS)

    External links

    Nomenclature
    HGNC (Hugo)NOTCH2   7882
    Cards
    AtlasNOTCH2ID41556ch1p12
    Entrez_Gene (NCBI)NOTCH2  4853  notch 2
    AliasesAGS2; HJCYS; hN2
    GeneCards (Weizmann)NOTCH2
    Ensembl hg19 (Hinxton)ENSG00000134250 [Gene_View]  chr1:120477736-120612317 [Contig_View]  NOTCH2 [Vega]
    Ensembl hg38 (Hinxton)ENSG00000134250 [Gene_View]  chr1:120477736-120612317 [Contig_View]  NOTCH2 [Vega]
    ICGC DataPortalENSG00000134250
    TCGA cBioPortalNOTCH2
    AceView (NCBI)NOTCH2
    Genatlas (Paris)NOTCH2
    WikiGenes4853
    SOURCE (Princeton)NOTCH2
    Genomic and cartography
    GoldenPath hg19 (UCSC)NOTCH2  -     chr1:120477736-120612317 -  1p13-p11   [Description]    (hg19-Feb_2009)
    GoldenPath hg38 (UCSC)NOTCH2  -     1p13-p11   [Description]    (hg38-Dec_2013)
    EnsemblNOTCH2 - 1p13-p11 [CytoView hg19]  NOTCH2 - 1p13-p11 [CytoView hg38]
    Mapping of homologs : NCBINOTCH2 [Mapview hg19]  NOTCH2 [Mapview hg38]
    OMIM102500   600275   610205   
    Gene and transcription
    Genbank (Entrez)AF308601 AF315356 AK027869 AK307843 AL049386
    RefSeq transcript (Entrez)NM_001200001 NM_024408
    RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008163 NT_032977 NW_004929290
    Consensus coding sequences : CCDS (NCBI)NOTCH2
    Cluster EST : UnigeneHs.487360 [ NCBI ]
    CGAP (NCI)Hs.487360
    Alternative Splicing GalleryENSG00000134250
    Gene ExpressionNOTCH2 [ NCBI-GEO ]   NOTCH2 [ EBI - ARRAY_EXPRESS ]   NOTCH2 [ SEEK ]   NOTCH2 [ MEM ]
    Gene Expression Viewer (FireBrowse)NOTCH2 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)4853
    GTEX Portal (Tissue expression)NOTCH2
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ04721 (Uniprot)
    NextProtQ04721  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProQ04721
    Splice isoforms : SwissVarQ04721 (Swissvar)
    PhosPhoSitePlusQ04721
    Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LNR (PS50258)   
    Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    DUF3454_notch    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    Notch    Notch_2    Notch_dom    Notch_NOD_dom    Notch_NODP_dom   
    Domain families : Pfam (Sanger)Ank_2 (PF12796)    DUF3454 (PF11936)    EGF (PF00008)    EGF_CA (PF07645)    NOD (PF06816)    NODP (PF07684)    Notch (PF00066)   
    Domain families : Pfam (NCBI)pfam12796    pfam11936    pfam00008    pfam07645    pfam06816    pfam07684    pfam00066   
    Domain families : Smart (EMBL)ANK (SM00248)  EGF (SM00181)  EGF_CA (SM00179)  NL (SM00004)  
    DMDM Disease mutations4853
    Blocks (Seattle)NOTCH2
    PDB (SRS)2OO4   
    PDB (PDBSum)2OO4   
    PDB (IMB)2OO4   
    PDB (RSDB)2OO4   
    Structural Biology KnowledgeBase2OO4   
    SCOP (Structural Classification of Proteins)2OO4   
    CATH (Classification of proteins structures)2OO4   
    SuperfamilyQ04721
    Human Protein AtlasENSG00000134250
    Peptide AtlasQ04721
    HPRD02606
    IPIIPI00297655   IPI00955451   IPI00941212   IPI00167217   IPI01015776   IPI00981408   
    Protein Interaction databases
    DIP (DOE-UCLA)Q04721
    IntAct (EBI)Q04721
    FunCoupENSG00000134250
    BioGRIDNOTCH2
    STRING (EMBL)NOTCH2
    ZODIACNOTCH2
    Ontologies - Pathways
    QuickGOQ04721
    Ontology : AmiGOGolgi membrane  cell fate determination  marginal zone B cell differentiation  pulmonary valve morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  nucleoplasm  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  apoptotic process  cell cycle arrest  Notch signaling pathway  Notch signaling pathway  multicellular organism development  nervous system development  negative regulation of cell proliferation  organ morphogenesis  cell surface  membrane  cell growth  stem cell population maintenance  hemopoiesis  intracellular receptor signaling pathway  transcription factor activity, ligand-activated RNA polymerase II transcription factor binding  tissue regeneration  negative regulation of apoptotic process  receptor complex  positive regulation of Ras protein signal transduction  bone remodeling  regulation of developmental process  atrial septum morphogenesis  Notch signaling involved in heart development  
    Ontology : EGO-EBIGolgi membrane  cell fate determination  marginal zone B cell differentiation  pulmonary valve morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  nucleoplasm  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  apoptotic process  cell cycle arrest  Notch signaling pathway  Notch signaling pathway  multicellular organism development  nervous system development  negative regulation of cell proliferation  organ morphogenesis  cell surface  membrane  cell growth  stem cell population maintenance  hemopoiesis  intracellular receptor signaling pathway  transcription factor activity, ligand-activated RNA polymerase II transcription factor binding  tissue regeneration  negative regulation of apoptotic process  receptor complex  positive regulation of Ras protein signal transduction  bone remodeling  regulation of developmental process  atrial septum morphogenesis  Notch signaling involved in heart development  
    Pathways : BIOCARTASegmentation Clock [Genes]   
    Pathways : KEGGDorso-ventral axis formation    Notch signaling pathway    Thyroid hormone signaling pathway    MicroRNAs in cancer   
    REACTOMEQ04721 [protein]
    REACTOME PathwaysR-HSA-350054 Notch-HLH transcription pathway [pathway]
    REACTOME PathwaysR-HSA-1912420 Pre-NOTCH Processing in Golgi [pathway]
    REACTOME PathwaysR-HSA-1912408 Pre-NOTCH Transcription and Translation [pathway]
    REACTOME PathwaysR-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum [pathway]
    REACTOME PathwaysR-HSA-2197563 NOTCH2 intracellular domain regulates transcription [pathway]
    REACTOME PathwaysR-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus [pathway]
    NDEx NetworkNOTCH2
    Atlas of Cancer Signalling NetworkNOTCH2
    Wikipedia pathwaysNOTCH2
    Orthology - Evolution
    OrthoDB4853
    GeneTree (enSembl)ENSG00000134250
    Phylogenetic Trees/Animal Genes : TreeFamNOTCH2
    Homologs : HomoloGeneNOTCH2
    Homology/Alignments : Family Browser (UCSC)NOTCH2
    Gene fusions - Rearrangements
    Fusion : MitelmanATP1A1/NOTCH2 [1p13.1/1p12]  [t(1;1)(p12;p13)]  
    Fusion : MitelmanDNAJC11/NOTCH2 [1p36.31/1p12]  [t(1;1)(p12;p36)]  
    Fusion : MitelmanMAGI3/NOTCH2 [1p13.2/1p12]  [t(1;1)(p12;p13)]  
    Fusion : MitelmanNOTCH2/CEP128 [1p12/14q31.1]  [t(1;14)(p12;q31)]  
    Fusion : MitelmanNOTCH2/MNDA [1p12/1q23.1]  [t(1;1)(p12;q23)]  
    Fusion : MitelmanNOTCH2/PSMA5 [1p12/1p13.3]  [t(1;1)(p12;p13)]  
    Fusion : MitelmanPTGFRN/NOTCH2 [1p13.1/1p12]  [t(1;1)(p12;p13)]  
    Fusion : MitelmanSEC22B/NOTCH2 [1q21.1/1p12]  [t(1;1)(p12;q21)]  
    Fusion: TCGAATP1A1 1p13.1 NOTCH2 1p12 BRCA
    Fusion: TCGAMAGI3 1p13.2 NOTCH2 1p12 BRCA
    Fusion: TCGANOTCH2 1p12 MNDA 1q23.1 OV
    Fusion: TCGANOTCH2 1p12 PSMA5 1p13.3 OV
    Fusion: TCGANOTCH2 1p12 SPAG17 1p12 HNSC
    Fusion: TCGAPTGFRN 1p13.1 NOTCH2 1p12 BRCA
    Fusion Cancer (Beijing)PTGFRN [1p13.1]  -  NOTCH2 [1p12]  [FUSC001899]
    Polymorphisms : SNP, variants
    NCBI Variation ViewerNOTCH2 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH2
    dbVarNOTCH2
    ClinVarNOTCH2
    1000_GenomesNOTCH2 
    Exome Variant ServerNOTCH2
    ExAC (Exome Aggregation Consortium)NOTCH2 (select the gene name)
    Genetic variants : HAPMAP4853
    Genomic Variants (DGV)NOTCH2 [DGVbeta]
    Mutations
    ICGC Data PortalNOTCH2 
    TCGA Data PortalNOTCH2 
    Broad Tumor PortalNOTCH2
    OASIS PortalNOTCH2 [ Somatic mutations - Copy number]
    Cancer Gene: CensusNOTCH2 
    Somatic Mutations in Cancer : COSMICNOTCH2 
    intOGen PortalNOTCH2
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    LOVD (Leiden Open Variation Database)Mendelian genes
    LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
    BioMutasearch NOTCH2
    DgiDB (Drug Gene Interaction Database)NOTCH2
    DoCM (Curated mutations)NOTCH2 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)NOTCH2 (select a term)
    intoGenNOTCH2
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
    Diseases
    DECIPHER (Syndromes)1:120477736-120612317  ENSG00000134250
    CONAN: Copy Number AnalysisNOTCH2 
    Mutations and Diseases : HGMDNOTCH2
    OMIM102500    600275    610205   
    MedgenNOTCH2
    Genetic Testing Registry NOTCH2
    NextProtQ04721 [Medical]
    TSGene4853
    GENETestsNOTCH2
    Huge Navigator NOTCH2 [HugePedia]
    snp3D : Map Gene to Disease4853
    BioCentury BCIQNOTCH2
    ClinGenNOTCH2 (curated)
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD4853
    Chemical/Pharm GKB GenePA31684
    Clinical trialNOTCH2
    Miscellaneous
    canSAR (ICR)NOTCH2 (select the gene name)
    Probes
    Litterature
    PubMed186 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineNOTCH2
    EVEXNOTCH2
    GoPubMedNOTCH2
    iHOPNOTCH2
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Wed Sep 28 16:03:53 CEST 2016

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