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NOTCH2NL (notch 2 N-terminal like)

Identity

Alias_namesNotch homolog 2 (Drosophila) N-terminal like
Alias_symbol (synonym)N2N
Other alias
HGNC (Hugo) NOTCH2NL
LocusID (NCBI) 388677
Atlas_Id 54507
Location 1q21.1  [Link to chromosome band 1q21]
Location_base_pair Starts at 146151908 and ends at 146229032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NOTCH2NL (1q21.1) / NBPF10 (1q21.1)NOTCH2NL (1q21.1) / UBE2H (7q32.2)TXNIP (1q21.1) / NOTCH2NL (1q21.1)
NOTCH2NL 1q21.1 / UBE2H 7q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q21;q21) NOTCH2NL/NBPF10


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  Lung: Translocations in Small Cell Carcinoma
t(1;1)(q21;q21) NOTCH2NL/NBPF10
t(1;1)(q21;q21) NOTCH2NL/NBPF10
t(1;1)(q21;q21) NOTCH2NL/NBPF10
t(1;1)(q21;q21) NOTCH2NL/NBPF10
t(1;1)(q21;q21) NOTCH2NL/NBPF10
t(1;1)(q21;q21) TXNIP/NOTCH2NL
t(1;7)(q21;q32) NOTCH2NL/UBE2H


External links

Nomenclature
HGNC (Hugo)NOTCH2NL   31862
Cards
Entrez_Gene (NCBI)NOTCH2NL  388677  notch 2 N-terminal like
AliasesN2N
GeneCards (Weizmann)NOTCH2NL
Ensembl hg19 (Hinxton)ENSG00000264343 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264343 [Gene_View]  ENSG00000264343 [Sequence]  chr1:146151908-146229032 [Contig_View]  NOTCH2NL [Vega]
ICGC DataPortalENSG00000264343
TCGA cBioPortalNOTCH2NL
AceView (NCBI)NOTCH2NL
Genatlas (Paris)NOTCH2NL
WikiGenes388677
SOURCE (Princeton)NOTCH2NL
Genetics Home Reference (NIH)NOTCH2NL
Genomic and cartography
GoldenPath hg38 (UCSC)NOTCH2NL  -     chr1:146151908-146229032 -  1q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOTCH2NL  -     1q21.1   [Description]    (hg19-Feb_2009)
EnsemblNOTCH2NL - 1q21.1 [CytoView hg19]  NOTCH2NL - 1q21.1 [CytoView hg38]
Mapping of homologs : NCBINOTCH2NL [Mapview hg19]  NOTCH2NL [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK000887 AK022008 AK075065 AL833369 BC010154
RefSeq transcript (Entrez)NM_203458
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOTCH2NL
Cluster EST : UnigeneHs.728902 [ NCBI ]
CGAP (NCI)Hs.728902
Alternative Splicing GalleryENSG00000264343
Gene ExpressionNOTCH2NL [ NCBI-GEO ]   NOTCH2NL [ EBI - ARRAY_EXPRESS ]   NOTCH2NL [ SEEK ]   NOTCH2NL [ MEM ]
Gene Expression Viewer (FireBrowse)NOTCH2NL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388677
GTEX Portal (Tissue expression)NOTCH2NL
Human Protein AtlasENSG00000264343-NOTCH2NL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3S9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3S9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3S9
Splice isoforms : SwissVarQ7Z3S9
PhosPhoSitePlusQ7Z3S9
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam00008    pfam07645   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)NOTCH2NL
DMDM Disease mutations388677
Blocks (Seattle)NOTCH2NL
SuperfamilyQ7Z3S9
Human Protein Atlas [tissue]ENSG00000264343-NOTCH2NL [tissue]
Peptide AtlasQ7Z3S9
HPRD14833
IPIIPI00515007   IPI00843817   IPI00335544   IPI00983804   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3S9
IntAct (EBI)Q7Z3S9
FunCoupENSG00000264343
BioGRIDNOTCH2NL
STRING (EMBL)NOTCH2NL
ZODIACNOTCH2NL
Ontologies - Pathways
QuickGOQ7Z3S9
Ontology : AmiGOcalcium ion binding  protein binding  extracellular region  cytoplasm  Notch signaling pathway  multicellular organism development  cell differentiation  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular region  cytoplasm  Notch signaling pathway  multicellular organism development  cell differentiation  
NDEx NetworkNOTCH2NL
Atlas of Cancer Signalling NetworkNOTCH2NL
Wikipedia pathwaysNOTCH2NL
Orthology - Evolution
OrthoDB388677
GeneTree (enSembl)ENSG00000264343
Phylogenetic Trees/Animal Genes : TreeFamNOTCH2NL
HOVERGENQ7Z3S9
HOGENOMQ7Z3S9
Homologs : HomoloGeneNOTCH2NL
Homology/Alignments : Family Browser (UCSC)NOTCH2NL
Gene fusions - Rearrangements
Fusion : MitelmanNOTCH2NL/UBE2H [1q21.1/7q32.2]  
Fusion : MitelmanTXNIP/NOTCH2NL [1q21.1/1q21.1]  [t(1;1)(q21;q21)]  
Fusion PortalNOTCH2NL 1q21.1 UBE2H 7q32.2 OV
Fusion : QuiverNOTCH2NL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTCH2NL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH2NL
dbVarNOTCH2NL
ClinVarNOTCH2NL
1000_GenomesNOTCH2NL 
Exome Variant ServerNOTCH2NL
ExAC (Exome Aggregation Consortium)ENSG00000264343
GNOMAD BrowserENSG00000264343
Genetic variants : HAPMAP388677
Genomic Variants (DGV)NOTCH2NL [DGVbeta]
DECIPHERNOTCH2NL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOTCH2NL 
Mutations
ICGC Data PortalNOTCH2NL 
TCGA Data PortalNOTCH2NL 
Broad Tumor PortalNOTCH2NL
OASIS PortalNOTCH2NL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOTCH2NL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOTCH2NL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOTCH2NL
DgiDB (Drug Gene Interaction Database)NOTCH2NL
DoCM (Curated mutations)NOTCH2NL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOTCH2NL (select a term)
intoGenNOTCH2NL
Cancer3DNOTCH2NL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETNOTCH2NL
MedgenNOTCH2NL
Genetic Testing Registry NOTCH2NL
NextProtQ7Z3S9 [Medical]
TSGene388677
GENETestsNOTCH2NL
Target ValidationNOTCH2NL
Huge Navigator NOTCH2NL [HugePedia]
snp3D : Map Gene to Disease388677
BioCentury BCIQNOTCH2NL
ClinGenNOTCH2NL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD388677
Chemical/Pharm GKB GenePA134983899
Clinical trialNOTCH2NL
Miscellaneous
canSAR (ICR)NOTCH2NL (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOTCH2NL
EVEXNOTCH2NL
GoPubMedNOTCH2NL
iHOPNOTCH2NL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:40:31 CEST 2018

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