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NOTCH2NLA (notch 2 N-terminal like A)

Identity

Alias (NCBI)N2N
NOTCH2NL
HGNC (Hugo) NOTCH2NLA
LocusID (NCBI) 388677
Atlas_Id 80439
Location 1q21.1  [Link to chromosome band 1q21]
Location_base_pair Starts at 146151908 and ends at 146229032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)NOTCH2NLA   31862
Cards
Entrez_Gene (NCBI)NOTCH2NLA    notch 2 N-terminal like A
AliasesN2N; NOTCH2NL
GeneCards (Weizmann)NOTCH2NLA
Ensembl hg19 (Hinxton)ENSG00000264343 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000264343 [Gene_View]  ENSG00000264343 [Sequence]  chr1:146151908-146229032 [Contig_View]  NOTCH2NLA [Vega]
ICGC DataPortalENSG00000264343
TCGA cBioPortalNOTCH2NLA
AceView (NCBI)NOTCH2NLA
Genatlas (Paris)NOTCH2NLA
SOURCE (Princeton)NOTCH2NLA
Genetics Home Reference (NIH)NOTCH2NLA
Genomic and cartography
GoldenPath hg38 (UCSC)NOTCH2NLA  -     chr1:146151908-146229032 -  1q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOTCH2NLA  -     1q21.1   [Description]    (hg19-Feb_2009)
GoldenPathNOTCH2NLA - 1q21.1 [CytoView hg19]  NOTCH2NLA - 1q21.1 [CytoView hg38]
ImmunoBaseENSG00000264343
Genome Data Viewer NCBINOTCH2NLA [Mapview hg19]  
OMIM618023   
Gene and transcription
Genbank (Entrez)AK000887 AK022008 AK075065 AL833369 BC010154
RefSeq transcript (Entrez)NM_001364006 NM_203458
Consensus coding sequences : CCDS (NCBI)NOTCH2NLA
Gene ExpressionNOTCH2NLA [ NCBI-GEO ]   NOTCH2NLA [ EBI - ARRAY_EXPRESS ]   NOTCH2NLA [ SEEK ]   NOTCH2NLA [ MEM ]
Gene Expression Viewer (FireBrowse)NOTCH2NLA [ Firebrowse - Broad ]
GenevisibleExpression of NOTCH2NLA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388677
GTEX Portal (Tissue expression)NOTCH2NLA
Human Protein AtlasENSG00000264343-NOTCH2NLA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3S9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3S9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3S9
PhosPhoSitePlusQ7Z3S9
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam00008    pfam07645   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)NOTCH2NLA
SuperfamilyQ7Z3S9
AlphaFold pdb e-kbQ7Z3S9   
Human Protein Atlas [tissue]ENSG00000264343-NOTCH2NLA [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3S9
IntAct (EBI)Q7Z3S9
BioGRIDNOTCH2NLA
STRING (EMBL)NOTCH2NLA
ZODIACNOTCH2NLA
Ontologies - Pathways
QuickGOQ7Z3S9
Ontology : AmiGONotch binding  Notch binding  calcium ion binding  protein binding  extracellular region  cytoplasm  Notch signaling pathway  cerebral cortex development  cell differentiation  positive regulation of Notch signaling pathway  
Ontology : EGO-EBINotch binding  Notch binding  calcium ion binding  protein binding  extracellular region  cytoplasm  Notch signaling pathway  cerebral cortex development  cell differentiation  positive regulation of Notch signaling pathway  
NDEx NetworkNOTCH2NLA
Atlas of Cancer Signalling NetworkNOTCH2NLA
Wikipedia pathwaysNOTCH2NLA
Orthology - Evolution
OrthoDB388677
GeneTree (enSembl)ENSG00000264343
Phylogenetic Trees/Animal Genes : TreeFamNOTCH2NLA
Homologs : HomoloGeneNOTCH2NLA
Homology/Alignments : Family Browser (UCSC)NOTCH2NLA
Gene fusions - Rearrangements
Fusion : QuiverNOTCH2NLA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTCH2NLA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH2NLA
dbVarNOTCH2NLA
ClinVarNOTCH2NLA
MonarchNOTCH2NLA
1000_GenomesNOTCH2NLA 
Exome Variant ServerNOTCH2NLA
GNOMAD BrowserENSG00000264343
Varsome BrowserNOTCH2NLA
ACMGNOTCH2NLA variants
VarityQ7Z3S9
Genomic Variants (DGV)NOTCH2NLA [DGVbeta]
DECIPHERNOTCH2NLA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOTCH2NLA 
Mutations
ICGC Data PortalNOTCH2NLA 
TCGA Data PortalNOTCH2NLA 
Broad Tumor PortalNOTCH2NLA
OASIS PortalNOTCH2NLA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOTCH2NLA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOTCH2NLA
Mutations and Diseases : HGMDNOTCH2NLA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNOTCH2NLA
DgiDB (Drug Gene Interaction Database)NOTCH2NLA
DoCM (Curated mutations)NOTCH2NLA
CIViC (Clinical Interpretations of Variants in Cancer)NOTCH2NLA
Cancer3DNOTCH2NLA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618023   
Orphanet
DisGeNETNOTCH2NLA
MedgenNOTCH2NLA
Genetic Testing Registry NOTCH2NLA
NextProtQ7Z3S9 [Medical]
GENETestsNOTCH2NLA
Target ValidationNOTCH2NLA
Huge Navigator NOTCH2NLA [HugePedia]
ClinGenNOTCH2NLA
Clinical trials, drugs, therapy
MyCancerGenomeNOTCH2NLA
Protein Interactions : CTDNOTCH2NLA
Pharm GKB GenePA134983899
PharosQ7Z3S9
Clinical trialNOTCH2NLA
Miscellaneous
canSAR (ICR)NOTCH2NLA
HarmonizomeNOTCH2NLA
DataMed IndexNOTCH2NLA
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNOTCH2NLA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:56 CEST 2021

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