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NOTCH2NLC (notch 2 N-terminal like C)

Identity

Alias (NCBI)N2N
NIID
NOTCH2NL
NOTCH2NLA
HGNC (Hugo) NOTCH2NLC
LocusID (NCBI) 100996717
Atlas_Id 80366
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 149390638 and ends at 149465302 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)NOTCH2NLC   53924
Cards
Entrez_Gene (NCBI)NOTCH2NLC  100996717  notch 2 N-terminal like C
AliasesN2N; NIID; NOTCH2NL; NOTCH2NLA
GeneCards (Weizmann)NOTCH2NLC
Ensembl hg19 (Hinxton)ENSG00000286219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000286219 [Gene_View]  ENSG00000286219 [Sequence]  chr1:149390638-149465302 [Contig_View]  NOTCH2NLC [Vega]
ICGC DataPortalENSG00000286219
TCGA cBioPortalNOTCH2NLC
AceView (NCBI)NOTCH2NLC
Genatlas (Paris)NOTCH2NLC
WikiGenes100996717
SOURCE (Princeton)NOTCH2NLC
Genetics Home Reference (NIH)NOTCH2NLC
Genomic and cartography
GoldenPath hg38 (UCSC)NOTCH2NLC  -     chr1:149390638-149465302 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOTCH2NLC  -     1q21.2   [Description]    (hg19-Feb_2009)
GoldenPathNOTCH2NLC - 1q21.2 [CytoView hg19]  NOTCH2NLC - 1q21.2 [CytoView hg38]
ImmunoBaseENSG00000286219
genome Data Viewer NCBINOTCH2NLC [Mapview hg19]  
OMIM603472   618025   
Gene and transcription
Genbank (Entrez)MH721900
RefSeq transcript (Entrez)NM_001364012 NM_001364013
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOTCH2NLC
Alternative Splicing GalleryENSG00000286219
Gene ExpressionNOTCH2NLC [ NCBI-GEO ]   NOTCH2NLC [ EBI - ARRAY_EXPRESS ]   NOTCH2NLC [ SEEK ]   NOTCH2NLC [ MEM ]
Gene Expression Viewer (FireBrowse)NOTCH2NLC [ Firebrowse - Broad ]
GenevisibleExpression of NOTCH2NLC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100996717
GTEX Portal (Tissue expression)NOTCH2NLC
Human Protein AtlasENSG00000286219-NOTCH2NLC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DPK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DPK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DPK4
Splice isoforms : SwissVarP0DPK4
PhosPhoSitePlusP0DPK4
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam00008    pfam07645   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)NOTCH2NLC
DMDM Disease mutations100996717
Blocks (Seattle)NOTCH2NLC
SuperfamilyP0DPK4
Human Protein Atlas [tissue]ENSG00000286219-NOTCH2NLC [tissue]
Peptide AtlasP0DPK4
Protein Interaction databases
DIP (DOE-UCLA)P0DPK4
IntAct (EBI)P0DPK4
FunCoupENSG00000286219
BioGRIDNOTCH2NLC
STRING (EMBL)NOTCH2NLC
ZODIACNOTCH2NLC
Ontologies - Pathways
QuickGOP0DPK4
Ontology : AmiGOcalcium ion binding  protein binding  extracellular region  Notch signaling pathway  cerebral cortex development  positive regulation of Notch signaling pathway  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular region  Notch signaling pathway  cerebral cortex development  positive regulation of Notch signaling pathway  
NDEx NetworkNOTCH2NLC
Atlas of Cancer Signalling NetworkNOTCH2NLC
Wikipedia pathwaysNOTCH2NLC
Orthology - Evolution
OrthoDB100996717
GeneTree (enSembl)ENSG00000286219
Phylogenetic Trees/Animal Genes : TreeFamNOTCH2NLC
HOGENOMP0DPK4
Homologs : HomoloGeneNOTCH2NLC
Homology/Alignments : Family Browser (UCSC)NOTCH2NLC
Gene fusions - Rearrangements
Fusion : QuiverNOTCH2NLC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTCH2NLC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH2NLC
dbVarNOTCH2NLC
ClinVarNOTCH2NLC
1000_GenomesNOTCH2NLC 
Exome Variant ServerNOTCH2NLC
GNOMAD BrowserENSG00000286219
Varsome BrowserNOTCH2NLC
Genetic variants : HAPMAP100996717
Genomic Variants (DGV)NOTCH2NLC [DGVbeta]
DECIPHERNOTCH2NLC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOTCH2NLC 
Mutations
ICGC Data PortalNOTCH2NLC 
TCGA Data PortalNOTCH2NLC 
Broad Tumor PortalNOTCH2NLC
OASIS PortalNOTCH2NLC [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNOTCH2NLC
BioMutasearch NOTCH2NLC
DgiDB (Drug Gene Interaction Database)NOTCH2NLC
DoCM (Curated mutations)NOTCH2NLC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOTCH2NLC (select a term)
intoGenNOTCH2NLC
Cancer3DNOTCH2NLC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603472    618025   
Orphanet
DisGeNETNOTCH2NLC
MedgenNOTCH2NLC
Genetic Testing Registry NOTCH2NLC
NextProtP0DPK4 [Medical]
TSGene100996717
GENETestsNOTCH2NLC
Target ValidationNOTCH2NLC
Huge Navigator NOTCH2NLC [HugePedia]
snp3D : Map Gene to Disease100996717
BioCentury BCIQNOTCH2NLC
ClinGenNOTCH2NLC
Clinical trials, drugs, therapy
Protein Interactions : CTD100996717
Clinical trialNOTCH2NLC
Miscellaneous
canSAR (ICR)NOTCH2NLC (select the gene name)
HarmonizomeNOTCH2NLC
DataMed IndexNOTCH2NLC
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOTCH2NLC
EVEXNOTCH2NLC
GoPubMedNOTCH2NLC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:19:51 CEST 2020

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