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NOTCH4 (notch 4)

Identity

Other namesINT3
HGNC (Hugo) NOTCH4
LocusID (NCBI) 4855
Location 6p21.32
Location_base_pair Starts at 32162620 and ends at 32191844 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NOTCH4   7884
Cards
Entrez_Gene (NCBI)NOTCH4  4855  notch 4
GeneCards (Weizmann)NOTCH4
Ensembl (Hinxton)ENSG00000204301 [Gene_View]  chr6:32162620-32191844 [Contig_View]  NOTCH4 [Vega]
ICGC DataPortalENSG00000204301
cBioPortalNOTCH4
AceView (NCBI)NOTCH4
Genatlas (Paris)NOTCH4
WikiGenes4855
SOURCE (Princeton)NM_004557
Genomic and cartography
GoldenPath (UCSC)NOTCH4  -  6p21.32   chr6:32162620-32191844 -  6p21.32   [Description]    (hg19-Feb_2009)
EnsemblNOTCH4 - 6p21.32 [CytoView]
Mapping of homologs : NCBINOTCH4 [Mapview]
OMIM164951   
Gene and transcription
Genbank (Entrez)AK131314 AK290785 AK293692 AK294161 AL705928
RefSeq transcript (Entrez)NM_004557
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_028190 NT_007592 NT_113891 NT_167244 NT_167246 NT_167247 NT_167248 NT_167249 NW_001838980 NW_004929326
Consensus coding sequences : CCDS (NCBI)NOTCH4
Cluster EST : UnigeneHs.436100 [ NCBI ]
CGAP (NCI)Hs.436100
Alternative Splicing : Fast-db (Paris)GSHG0033517
Alternative Splicing GalleryENSG00000204301
Gene ExpressionNOTCH4 [ NCBI-GEO ]     NOTCH4 [ SEEK ]   NOTCH4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99466 (Uniprot)
NextProtQ99466  [Medical]
With graphics : InterProQ99466
Splice isoforms : SwissVarQ99466 (Swissvar)
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LNR (PS50258)   
Domains : Interpro (EBI)Ankyrin_rpt [organisation]   Ankyrin_rpt-contain_dom [organisation]   EG-like_dom [organisation]   EGF-like_Ca-bd_dom [organisation]   EGF-like_CS [organisation]   EGF-type_Asp/Asn_hydroxyl_site [organisation]   EGF_Ca-bd_CS [organisation]   Growth_fac_rcpt_N_dom [organisation]   Notch [organisation]   Notch_4 [organisation]   Notch_dom [organisation]   Notch_NODP_dom [organisation]  
Related proteins : CluSTrQ99466
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    EGF (PF00008)    EGF_CA (PF07645)    hEGF (PF12661)    NODP (PF07684)    Notch (PF00066)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam00008    pfam07645    pfam12661    pfam07684    pfam00066   
Domain families : Smart (EMBL)ANK (SM00248)  EGF (SM00181)  EGF_CA (SM00179)  NL (SM00004)  
DMDM Disease mutations4855
Blocks (Seattle)Q99466
Human Protein AtlasENSG00000204301 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ99466
HPRD01290
IPIIPI00829649   IPI00785109   IPI00942401   IPI00911053   IPI00909881   IPI00792257   IPI00829858   IPI00893634   
Protein Interaction databases
DIP (DOE-UCLA)Q99466
IntAct (EBI)Q99466
FunCoupENSG00000204301
BioGRIDNOTCH4
InParanoidQ99466
Interologous Interaction database Q99466
IntegromeDBNOTCH4
STRING (EMBL)NOTCH4
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  patterning of blood vessels  cell fate determination  morphogenesis of a branching structure  endothelial cell morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  integral component of plasma membrane  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  Notch receptor processing  positive regulation of transcription of Notch receptor target  embryo development  cell surface  gene expression  hemopoiesis  cell differentiation  mammary gland development  negative regulation of cell differentiation  negative regulation of endothelial cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  
Ontology : EGO-EBIGolgi membrane  patterning of blood vessels  cell fate determination  morphogenesis of a branching structure  endothelial cell morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  integral component of plasma membrane  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  Notch receptor processing  positive regulation of transcription of Notch receptor target  embryo development  cell surface  gene expression  hemopoiesis  cell differentiation  mammary gland development  negative regulation of cell differentiation  negative regulation of endothelial cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  
Pathways : KEGGDorso-ventral axis formation    Notch signaling pathway    Thyroid hormone signaling pathway    MicroRNAs in cancer   
Protein Interaction DatabaseNOTCH4
Wikipedia pathwaysNOTCH4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NOTCH4
snp3D : Map Gene to Disease4855
SNP (GeneSNP Utah)NOTCH4
SNP : HGBaseNOTCH4
Genetic variants : HAPMAPNOTCH4
Exome VariantNOTCH4
1000_GenomesNOTCH4 
ICGC programENSG00000204301 
Somatic Mutations in Cancer : COSMICNOTCH4 
CONAN: Copy Number AnalysisNOTCH4 
Mutations and Diseases : HGMDNOTCH4
Mutations and Diseases : intOGenNOTCH4
Genomic VariantsNOTCH4  NOTCH4 [DGVbeta]
dbVarNOTCH4
ClinVarNOTCH4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM164951   
MedgenNOTCH4
GENETestsNOTCH4
Disease Genetic AssociationNOTCH4
Huge Navigator NOTCH4 [HugePedia]  NOTCH4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneNOTCH4
Homology/Alignments : Family Browser (UCSC)NOTCH4
Phylogenetic Trees/Animal Genes : TreeFamNOTCH4
Chemical/Protein Interactions : CTD4855
Chemical/Pharm GKB GenePA31686
Clinical trialNOTCH4
Cancer Resource (Charite)ENSG00000204301
Other databases
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
CoreMineNOTCH4
iHOPNOTCH4
OncoSearchNOTCH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:57:56 CEST 2014

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