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NOTCH4 (notch 4)

Identity

Alias_namesINT3
Notch (Drosophila) homolog 4
Notch homolog 4 (Drosophila)
HGNC (Hugo) NOTCH4
LocusID (NCBI) 4855
Atlas_Id 41558
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32162620 and ends at 32191844 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CNNM2 (10q24.32) / NOTCH4 (6p21.32)CNNM2 10q24.32 / NOTCH4 6p21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOTCH4   7884
Cards
Entrez_Gene (NCBI)NOTCH4  4855  notch 4
AliasesINT3
GeneCards (Weizmann)NOTCH4
Ensembl hg19 (Hinxton)ENSG00000204301 [Gene_View]  chr6:32162620-32191844 [Contig_View]  NOTCH4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204301 [Gene_View]  chr6:32162620-32191844 [Contig_View]  NOTCH4 [Vega]
ICGC DataPortalENSG00000204301
TCGA cBioPortalNOTCH4
AceView (NCBI)NOTCH4
Genatlas (Paris)NOTCH4
WikiGenes4855
SOURCE (Princeton)NOTCH4
Genetics Home Reference (NIH)NOTCH4
Genomic and cartography
GoldenPath hg19 (UCSC)NOTCH4  -     chr6:32162620-32191844 -  6p21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NOTCH4  -     6p21.32   [Description]    (hg38-Dec_2013)
EnsemblNOTCH4 - 6p21.32 [CytoView hg19]  NOTCH4 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBINOTCH4 [Mapview hg19]  NOTCH4 [Mapview hg38]
OMIM164951   
Gene and transcription
Genbank (Entrez)AK131314 AK290785 AK293692 AK294161 AL705928
RefSeq transcript (Entrez)NM_004557
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_028190 NT_007592 NT_113891 NT_167244 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)NOTCH4
Cluster EST : UnigeneHs.436100 [ NCBI ]
CGAP (NCI)Hs.436100
Alternative Splicing GalleryENSG00000204301
Gene ExpressionNOTCH4 [ NCBI-GEO ]   NOTCH4 [ EBI - ARRAY_EXPRESS ]   NOTCH4 [ SEEK ]   NOTCH4 [ MEM ]
Gene Expression Viewer (FireBrowse)NOTCH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4855
GTEX Portal (Tissue expression)NOTCH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99466   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99466  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99466
Splice isoforms : SwissVarQ99466
PhosPhoSitePlusQ99466
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LNR (PS50258)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    Notch_4    Notch_dom    Notch_NOD_dom    Notch_NODP_dom   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)    hEGF (PF12661)    NOD (PF06816)    NODP (PF07684)    Notch (PF00066)   
Domain families : Pfam (NCBI)pfam00008    pfam07645    pfam12661    pfam06816    pfam07684    pfam00066   
Domain families : Smart (EMBL)ANK (SM00248)  EGF (SM00181)  EGF_CA (SM00179)  NL (SM00004)  
Conserved Domain (NCBI)NOTCH4
DMDM Disease mutations4855
Blocks (Seattle)NOTCH4
SuperfamilyQ99466
Human Protein AtlasENSG00000204301
Peptide AtlasQ99466
HPRD01290
IPIIPI00829649   IPI00785109   IPI00942401   IPI00911053   IPI00909881   IPI00792257   IPI00829858   IPI00893634   
Protein Interaction databases
DIP (DOE-UCLA)Q99466
IntAct (EBI)Q99466
FunCoupENSG00000204301
BioGRIDNOTCH4
STRING (EMBL)NOTCH4
ZODIACNOTCH4
Ontologies - Pathways
QuickGOQ99466
Ontology : AmiGOGolgi membrane  patterning of blood vessels  cell fate determination  morphogenesis of a branching structure  endothelial cell morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  integral component of plasma membrane  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  Notch receptor processing  positive regulation of transcription of Notch receptor target  embryo development  cell surface  hemopoiesis  cell differentiation  mammary gland development  negative regulation of cell differentiation  negative regulation of endothelial cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  
Ontology : EGO-EBIGolgi membrane  patterning of blood vessels  cell fate determination  morphogenesis of a branching structure  endothelial cell morphogenesis  receptor activity  calcium ion binding  protein binding  extracellular region  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  integral component of plasma membrane  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  Notch receptor processing  positive regulation of transcription of Notch receptor target  embryo development  cell surface  hemopoiesis  cell differentiation  mammary gland development  negative regulation of cell differentiation  negative regulation of endothelial cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  
Pathways : KEGGDorso-ventral axis formation    Notch signaling pathway    Thyroid hormone signaling pathway    MicroRNAs in cancer   
NDEx NetworkNOTCH4
Atlas of Cancer Signalling NetworkNOTCH4
Wikipedia pathwaysNOTCH4
Orthology - Evolution
OrthoDB4855
GeneTree (enSembl)ENSG00000204301
Phylogenetic Trees/Animal Genes : TreeFamNOTCH4
HOVERGENQ99466
HOGENOMQ99466
Homologs : HomoloGeneNOTCH4
Homology/Alignments : Family Browser (UCSC)NOTCH4
Gene fusions - Rearrangements
Fusion : MitelmanCNNM2/NOTCH4 [10q24.32/6p21.32]  [t(6;10)(p21;q24)]  
Fusion: TCGACNNM2 10q24.32 NOTCH4 6p21.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTCH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTCH4
dbVarNOTCH4
ClinVarNOTCH4
1000_GenomesNOTCH4 
Exome Variant ServerNOTCH4
ExAC (Exome Aggregation Consortium)NOTCH4 (select the gene name)
Genetic variants : HAPMAP4855
Genomic Variants (DGV)NOTCH4 [DGVbeta]
DECIPHER (Syndromes)6:32162620-32191844  ENSG00000204301
CONAN: Copy Number AnalysisNOTCH4 
Mutations
ICGC Data PortalNOTCH4 
TCGA Data PortalNOTCH4 
Broad Tumor PortalNOTCH4
OASIS PortalNOTCH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOTCH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOTCH4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOTCH4
DgiDB (Drug Gene Interaction Database)NOTCH4
DoCM (Curated mutations)NOTCH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOTCH4 (select a term)
intoGenNOTCH4
Cancer3DNOTCH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164951   
Orphanet
MedgenNOTCH4
Genetic Testing Registry NOTCH4
NextProtQ99466 [Medical]
TSGene4855
GENETestsNOTCH4
Huge Navigator NOTCH4 [HugePedia]
snp3D : Map Gene to Disease4855
BioCentury BCIQNOTCH4
ClinGenNOTCH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4855
Chemical/Pharm GKB GenePA31686
Clinical trialNOTCH4
Miscellaneous
canSAR (ICR)NOTCH4 (select the gene name)
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOTCH4
EVEXNOTCH4
GoPubMedNOTCH4
iHOPNOTCH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:46:03 CET 2016

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