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NOTUM (NOTUM, palmitoleoyl-protein carboxylesterase)

Identity

Alias_namesnotum pectinacetylesterase homolog (Drosophila)
Other aliashNOTUM
HGNC (Hugo) NOTUM
LocusID (NCBI) 147111
Atlas_Id 50255
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81952507 and ends at 81961181 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PYCR1 (17q25.3) / NOTUM (17q25.3)PYCR1 17q25.3 / NOTUM 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOTUM   27106
Cards
Entrez_Gene (NCBI)NOTUM  147111  NOTUM, palmitoleoyl-protein carboxylesterase
AliaseshNOTUM
GeneCards (Weizmann)NOTUM
Ensembl hg19 (Hinxton)ENSG00000185269 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185269 [Gene_View]  chr17:81952507-81961181 [Contig_View]  NOTUM [Vega]
ICGC DataPortalENSG00000185269
TCGA cBioPortalNOTUM
AceView (NCBI)NOTUM
Genatlas (Paris)NOTUM
WikiGenes147111
SOURCE (Princeton)NOTUM
Genetics Home Reference (NIH)NOTUM
Genomic and cartography
GoldenPath hg38 (UCSC)NOTUM  -     chr17:81952507-81961181 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOTUM  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblNOTUM - 17q25.3 [CytoView hg19]  NOTUM - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBINOTUM [Mapview hg19]  NOTUM [Mapview hg38]
OMIM609847   
Gene and transcription
Genbank (Entrez)AB062438 BC036872 BC060882 BX365997 HQ448542
RefSeq transcript (Entrez)NM_178493
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOTUM
Cluster EST : UnigeneHs.106137 [ NCBI ]
CGAP (NCI)Hs.106137
Alternative Splicing GalleryENSG00000185269
Gene ExpressionNOTUM [ NCBI-GEO ]   NOTUM [ EBI - ARRAY_EXPRESS ]   NOTUM [ SEEK ]   NOTUM [ MEM ]
Gene Expression Viewer (FireBrowse)NOTUM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147111
GTEX Portal (Tissue expression)NOTUM
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P988   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P988
Splice isoforms : SwissVarQ6P988
PhosPhoSitePlusQ6P988
Domains : Interpro (EBI)PAE/NOTUM   
Domain families : Pfam (Sanger)PAE (PF03283)   
Domain families : Pfam (NCBI)pfam03283   
Conserved Domain (NCBI)NOTUM
DMDM Disease mutations147111
Blocks (Seattle)NOTUM
PDB (SRS)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
PDB (PDBSum)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
PDB (IMB)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
PDB (RSDB)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
Structural Biology KnowledgeBase4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
SCOP (Structural Classification of Proteins)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
CATH (Classification of proteins structures)4UYU    4UYW    4UYZ    4UZ1    4UZ5    4UZ6    4UZ7    4UZ9    4UZA    4UZL    4UZQ    4WBH   
SuperfamilyQ6P988
Human Protein AtlasENSG00000185269
Peptide AtlasQ6P988
HPRD14073
IPIIPI00465159   IPI00925728   
Protein Interaction databases
DIP (DOE-UCLA)Q6P988
IntAct (EBI)Q6P988
FunCoupENSG00000185269
BioGRIDNOTUM
STRING (EMBL)NOTUM
ZODIACNOTUM
Ontologies - Pathways
QuickGOQ6P988
Ontology : AmiGOphospholipase C activity  extracellular region  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  protein depalmitoleylation  palmitoleyl hydrolase activity  
Ontology : EGO-EBIphospholipase C activity  extracellular region  Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  protein depalmitoleylation  palmitoleyl hydrolase activity  
NDEx NetworkNOTUM
Atlas of Cancer Signalling NetworkNOTUM
Wikipedia pathwaysNOTUM
Orthology - Evolution
OrthoDB147111
GeneTree (enSembl)ENSG00000185269
Phylogenetic Trees/Animal Genes : TreeFamNOTUM
HOVERGENQ6P988
HOGENOMQ6P988
Homologs : HomoloGeneNOTUM
Homology/Alignments : Family Browser (UCSC)NOTUM
Gene fusions - Rearrangements
Fusion : MitelmanPYCR1/NOTUM [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion: TCGAPYCR1 17q25.3 NOTUM 17q25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOTUM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOTUM
dbVarNOTUM
ClinVarNOTUM
1000_GenomesNOTUM 
Exome Variant ServerNOTUM
ExAC (Exome Aggregation Consortium)NOTUM (select the gene name)
Genetic variants : HAPMAP147111
Genomic Variants (DGV)NOTUM [DGVbeta]
DECIPHERNOTUM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOTUM 
Mutations
ICGC Data PortalNOTUM 
TCGA Data PortalNOTUM 
Broad Tumor PortalNOTUM
OASIS PortalNOTUM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOTUM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOTUM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOTUM
DgiDB (Drug Gene Interaction Database)NOTUM
DoCM (Curated mutations)NOTUM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOTUM (select a term)
intoGenNOTUM
Cancer3DNOTUM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609847   
Orphanet
MedgenNOTUM
Genetic Testing Registry NOTUM
NextProtQ6P988 [Medical]
TSGene147111
GENETestsNOTUM
Target ValidationNOTUM
Huge Navigator NOTUM [HugePedia]
snp3D : Map Gene to Disease147111
BioCentury BCIQNOTUM
ClinGenNOTUM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147111
Chemical/Pharm GKB GenePA142671250
Clinical trialNOTUM
Miscellaneous
canSAR (ICR)NOTUM (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOTUM
EVEXNOTUM
GoPubMedNOTUM
iHOPNOTUM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:09 CEST 2017

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