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NOV (nephroblastoma overexpressed)

Identity

Alias_namesnephroblastoma overexpressed gene
Alias_symbol (synonym)IGFBP9
CCN3
Other aliasIBP-9
IGFBP-9
NOVh
HGNC (Hugo) NOV
LocusID (NCBI) 4856
Atlas_Id 41559
Location 8q24.12  [Link to chromosome band 8q24]
Location_base_pair Starts at 119416312 and ends at 119424438 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NOV (8q24.12) / UTY (Yq11.221)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOV   7885
Cards
Entrez_Gene (NCBI)NOV  4856  nephroblastoma overexpressed
AliasesCCN3; IBP-9; IGFBP-9; IGFBP9; 
NOVh
GeneCards (Weizmann)NOV
Ensembl hg19 (Hinxton)ENSG00000136999 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136999 [Gene_View]  chr8:119416312-119424438 [Contig_View]  NOV [Vega]
ICGC DataPortalENSG00000136999
TCGA cBioPortalNOV
AceView (NCBI)NOV
Genatlas (Paris)NOV
WikiGenes4856
SOURCE (Princeton)NOV
Genetics Home Reference (NIH)NOV
Genomic and cartography
GoldenPath hg38 (UCSC)NOV  -     chr8:119416312-119424438 +  8q24.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOV  -     8q24.12   [Description]    (hg19-Feb_2009)
EnsemblNOV - 8q24.12 [CytoView hg19]  NOV - 8q24.12 [CytoView hg38]
Mapping of homologs : NCBINOV [Mapview hg19]  NOV [Mapview hg38]
OMIM164958   
Gene and transcription
Genbank (Entrez)AK294289 AK312355 AY082381 BC015028 CR457432
RefSeq transcript (Entrez)NM_002514
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOV
Cluster EST : UnigeneHs.235935 [ NCBI ]
CGAP (NCI)Hs.235935
Alternative Splicing GalleryENSG00000136999
Gene ExpressionNOV [ NCBI-GEO ]   NOV [ EBI - ARRAY_EXPRESS ]   NOV [ SEEK ]   NOV [ MEM ]
Gene Expression Viewer (FireBrowse)NOV [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4856
GTEX Portal (Tissue expression)NOV
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48745   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48745  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48745
Splice isoforms : SwissVarP48745
PhosPhoSitePlusP48745
Domaine pattern : Prosite (Expaxy)CTCK_1 (PS01185)    CTCK_2 (PS01225)    IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    TSP1 (PS50092)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)Cys_knot_C    Glyco_hormone_CN    Growth_fac_rcpt_    IGFBP-like    IGFBP_CNN    Insulin_GF-bd_Cys-rich_CS    TSP1_rpt    VWF_dom   
Domain families : Pfam (Sanger)Cys_knot (PF00007)    IGFBP (PF00219)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam00007    pfam00219    pfam00093   
Domain families : Smart (EMBL)CT (SM00041)  IB (SM00121)  TSP1 (SM00209)  VWC (SM00214)  
Conserved Domain (NCBI)NOV
DMDM Disease mutations4856
Blocks (Seattle)NOV
SuperfamilyP48745
Human Protein AtlasENSG00000136999
Peptide AtlasP48745
HPRD01291
IPIIPI00011140   
Protein Interaction databases
DIP (DOE-UCLA)P48745
IntAct (EBI)P48745
FunCoupENSG00000136999
BioGRIDNOV
STRING (EMBL)NOV
ZODIACNOV
Ontologies - Pathways
QuickGOP48745
Ontology : AmiGOangiogenesis  chondrocyte differentiation  Notch binding  integrin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  cytoplasm  cytoplasm  gap junction  gap junction  growth factor activity  regulation of gene expression  fibroblast migration  negative regulation of myotube differentiation  smooth muscle cell migration  negative regulation of cell growth  axon  dendrite  extracellular matrix  cell adhesion mediated by integrin  endothelial cell chemotaxis  negative regulation of NF-kappaB import into nucleus  neuronal cell body  intracellular membrane-bounded organelle  type B pancreatic cell proliferation  positive regulation of Notch signaling pathway  negative regulation of insulin secretion  smooth muscle cell proliferation  negative regulation of inflammatory response  cell chemotaxis  negative regulation of SMAD protein import into nucleus  hematopoietic stem cell homeostasis  endothelial cell-cell adhesion  negative regulation of monocyte chemotaxis  negative regulation of chondrocyte proliferation  negative regulation of sensory perception of pain  bone regeneration  
Ontology : EGO-EBIangiogenesis  chondrocyte differentiation  Notch binding  integrin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular space  cytoplasm  cytoplasm  gap junction  gap junction  growth factor activity  regulation of gene expression  fibroblast migration  negative regulation of myotube differentiation  smooth muscle cell migration  negative regulation of cell growth  axon  dendrite  extracellular matrix  cell adhesion mediated by integrin  endothelial cell chemotaxis  negative regulation of NF-kappaB import into nucleus  neuronal cell body  intracellular membrane-bounded organelle  type B pancreatic cell proliferation  positive regulation of Notch signaling pathway  negative regulation of insulin secretion  smooth muscle cell proliferation  negative regulation of inflammatory response  cell chemotaxis  negative regulation of SMAD protein import into nucleus  hematopoietic stem cell homeostasis  endothelial cell-cell adhesion  negative regulation of monocyte chemotaxis  negative regulation of chondrocyte proliferation  negative regulation of sensory perception of pain  bone regeneration  
NDEx NetworkNOV
Atlas of Cancer Signalling NetworkNOV
Wikipedia pathwaysNOV
Orthology - Evolution
OrthoDB4856
GeneTree (enSembl)ENSG00000136999
Phylogenetic Trees/Animal Genes : TreeFamNOV
HOVERGENP48745
HOGENOMP48745
Homologs : HomoloGeneNOV
Homology/Alignments : Family Browser (UCSC)NOV
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOV [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOV
dbVarNOV
ClinVarNOV
1000_GenomesNOV 
Exome Variant ServerNOV
ExAC (Exome Aggregation Consortium)NOV (select the gene name)
Genetic variants : HAPMAP4856
Genomic Variants (DGV)NOV [DGVbeta]
DECIPHERNOV [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOV 
Mutations
ICGC Data PortalNOV 
TCGA Data PortalNOV 
Broad Tumor PortalNOV
OASIS PortalNOV [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOV  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOV
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOV
DgiDB (Drug Gene Interaction Database)NOV
DoCM (Curated mutations)NOV (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOV (select a term)
intoGenNOV
Cancer3DNOV(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164958   
Orphanet
MedgenNOV
Genetic Testing Registry NOV
NextProtP48745 [Medical]
TSGene4856
GENETestsNOV
Target ValidationNOV
Huge Navigator NOV [HugePedia]
snp3D : Map Gene to Disease4856
BioCentury BCIQNOV
ClinGenNOV
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4856
Chemical/Pharm GKB GenePA31687
Clinical trialNOV
Miscellaneous
canSAR (ICR)NOV (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOV
EVEXNOV
GoPubMedNOV
iHOPNOV
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:01:50 CEST 2017

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