Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NOX1 (NADPH oxidase 1)

Identity

Alias_symbol (synonym)NOH1
NOH-1
MOX1
GP91-2
Other alias
HGNC (Hugo) NOX1
LocusID (NCBI) 27035
Atlas_Id 43856
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 100843324 and ends at 100874345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CACNA1D (3p21.1) / NOX1 (Xq22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOX1   7889
Cards
Entrez_Gene (NCBI)NOX1  27035  NADPH oxidase 1
AliasesGP91-2; MOX1; NOH-1; NOH1
GeneCards (Weizmann)NOX1
Ensembl hg19 (Hinxton)ENSG00000007952 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000007952 [Gene_View]  chrX:100843324-100874345 [Contig_View]  NOX1 [Vega]
ICGC DataPortalENSG00000007952
TCGA cBioPortalNOX1
AceView (NCBI)NOX1
Genatlas (Paris)NOX1
WikiGenes27035
SOURCE (Princeton)NOX1
Genetics Home Reference (NIH)NOX1
Genomic and cartography
GoldenPath hg38 (UCSC)NOX1  -     chrX:100843324-100874345 -  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOX1  -     Xq22.1   [Description]    (hg19-Feb_2009)
EnsemblNOX1 - Xq22.1 [CytoView hg19]  NOX1 - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBINOX1 [Mapview hg19]  NOX1 [Mapview hg38]
OMIM300225   
Gene and transcription
Genbank (Entrez)AF127763 AF166326 AF166327 AF166328 AI285296
RefSeq transcript (Entrez)NM_001271815 NM_007052 NM_013954 NM_013955
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOX1
Cluster EST : UnigeneHs.592227 [ NCBI ]
CGAP (NCI)Hs.592227
Alternative Splicing GalleryENSG00000007952
Gene ExpressionNOX1 [ NCBI-GEO ]   NOX1 [ EBI - ARRAY_EXPRESS ]   NOX1 [ SEEK ]   NOX1 [ MEM ]
Gene Expression Viewer (FireBrowse)NOX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27035
GTEX Portal (Tissue expression)NOX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5S8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5S8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5S8
Splice isoforms : SwissVarQ9Y5S8
Catalytic activity : Enzyme1.-.-.- [ Enzyme-Expasy ]   1.-.-.-1.-.-.- [ IntEnz-EBI ]   1.-.-.- [ BRENDA ]   1.-.-.- [ KEGG ]   
PhosPhoSitePlusQ9Y5S8
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)   
Domains : Interpro (EBI)Cyt_b245_heavy_chain    FAD-bd_8    Fd_Rdtase_FAD-bd    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    NOX1    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam08022    pfam01794    pfam08030   
Conserved Domain (NCBI)NOX1
DMDM Disease mutations27035
Blocks (Seattle)NOX1
SuperfamilyQ9Y5S8
Human Protein AtlasENSG00000007952
Peptide AtlasQ9Y5S8
HPRD02203
IPIIPI00292186   IPI00216593   IPI00747660   IPI00553089   IPI00336126   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5S8
IntAct (EBI)Q9Y5S8
FunCoupENSG00000007952
BioGRIDNOX1
STRING (EMBL)NOX1
ZODIACNOX1
Ontologies - Pathways
QuickGOQ9Y5S8
Ontology : AmiGOangiogenesis  regulation of systemic arterial blood pressure by renin-angiotensin  protein binding  early endosome  plasma membrane  NADP metabolic process  superoxide metabolic process  inflammatory response  signal transduction  regulation of blood pressure  positive regulation of cell proliferation  positive regulation of vascular endothelial growth factor production  proton transport  integral component of membrane  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  cell migration  cell junction  voltage-gated proton channel activity  extracellular matrix organization  regulation of ion transmembrane transport  superoxide anion generation  hydrogen peroxide metabolic process  NADPH oxidase complex  positive regulation of integrin biosynthetic process  respiratory burst  positive regulation of JNK cascade  metal ion binding  Rac GTPase binding  positive regulation of smooth muscle cell proliferation  NADP binding  intracellular pH elevation  oxidation-reduction process  invadopodium membrane  cellular response to hyperoxia  oxygen metabolic process  positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  cellular stress response to acidic pH  
Ontology : EGO-EBIangiogenesis  regulation of systemic arterial blood pressure by renin-angiotensin  protein binding  early endosome  plasma membrane  NADP metabolic process  superoxide metabolic process  inflammatory response  signal transduction  regulation of blood pressure  positive regulation of cell proliferation  positive regulation of vascular endothelial growth factor production  proton transport  integral component of membrane  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  cell migration  cell junction  voltage-gated proton channel activity  extracellular matrix organization  regulation of ion transmembrane transport  superoxide anion generation  hydrogen peroxide metabolic process  NADPH oxidase complex  positive regulation of integrin biosynthetic process  respiratory burst  positive regulation of JNK cascade  metal ion binding  Rac GTPase binding  positive regulation of smooth muscle cell proliferation  NADP binding  intracellular pH elevation  oxidation-reduction process  invadopodium membrane  cellular response to hyperoxia  oxygen metabolic process  positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  cellular stress response to acidic pH  
Pathways : BIOCARTACCR3 signaling in Eosinophils [Genes]    Free Radical Induced Apoptosis [Genes]   
Pathways : KEGGHIF-1 signaling pathway    Phagosome    Osteoclast differentiation    Leukocyte transendothelial migration   
NDEx NetworkNOX1
Atlas of Cancer Signalling NetworkNOX1
Wikipedia pathwaysNOX1
Orthology - Evolution
OrthoDB27035
GeneTree (enSembl)ENSG00000007952
Phylogenetic Trees/Animal Genes : TreeFamNOX1
HOVERGENQ9Y5S8
HOGENOMQ9Y5S8
Homologs : HomoloGeneNOX1
Homology/Alignments : Family Browser (UCSC)NOX1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOX1
dbVarNOX1
ClinVarNOX1
1000_GenomesNOX1 
Exome Variant ServerNOX1
ExAC (Exome Aggregation Consortium)NOX1 (select the gene name)
Genetic variants : HAPMAP27035
Genomic Variants (DGV)NOX1 [DGVbeta]
DECIPHERNOX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOX1 
Mutations
ICGC Data PortalNOX1 
TCGA Data PortalNOX1 
Broad Tumor PortalNOX1
OASIS PortalNOX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch NOX1
DgiDB (Drug Gene Interaction Database)NOX1
DoCM (Curated mutations)NOX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOX1 (select a term)
intoGenNOX1
Cancer3DNOX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300225   
Orphanet
MedgenNOX1
Genetic Testing Registry NOX1
NextProtQ9Y5S8 [Medical]
TSGene27035
GENETestsNOX1
Huge Navigator NOX1 [HugePedia]
snp3D : Map Gene to Disease27035
BioCentury BCIQNOX1
ClinGenNOX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27035
Chemical/Pharm GKB GenePA31690
Clinical trialNOX1
Miscellaneous
canSAR (ICR)NOX1 (select the gene name)
Probes
Litterature
PubMed173 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOX1
EVEXNOX1
GoPubMedNOX1
iHOPNOX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:28:59 CEST 2017

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