NOX3 (NADPH oxidase 3)

2007-12-01 Affiliation

Identity

HGNC

NOX3

LOCATION

6q25.3

LOCUSID

50508

ALIAS

GP91-3,MOX-2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50508
MIM: 607105
HGNC: 7890
Ensembl: ENSG00000074771

Variants:

dbSNP: 50508
ClinVar: 50508
TCGA: ENSG00000074771
COSMIC: NOX3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000074771	ENST00000159060	Q9HBY0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Leukocyte transendothelial migration	KEGG	ko04670
Leukocyte transendothelial migration	KEGG	hsa04670
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
HIF-1 signaling pathway	KEGG	hsa04066
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate NADPH Oxidases	REACTOME	R-HSA-5668599
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20647313	2010	The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.	82
16507994	2006	Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.	79
15824103	2005	The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.	61
15181005	2004	Nox3 regulation by NOXO1, p47phox, and p67phox.	44
21901141	2011	Impaired OXPHOS complex III in breast cancer.	34
17140397	2007	Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3.	32
17336700	2007	A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.	22
20102709	2010	NOX3-derived reactive oxygen species promote TNF-alpha-induced reductions in hepatocyte glycogen levels via a JNK pathway.	17
16949073	2006	Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3.	16

Citation

Dessen P

NOX3 (NADPH oxidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49920/nox3