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NOX3 (NADPH oxidase 3)

Identity

Alias (NCBI)GP91-3
MOX-2
HGNC (Hugo) NOX3
HGNC Alias symbGP91-3
LocusID (NCBI) 50508
Atlas_Id 49920
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 155395368 and ends at 155455839 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NOX3   7890
Cards
Entrez_Gene (NCBI)NOX3    NADPH oxidase 3
AliasesGP91-3; MOX-2
GeneCards (Weizmann)NOX3
Ensembl hg19 (Hinxton)ENSG00000074771 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074771 [Gene_View]  ENSG00000074771 [Sequence]  chr6:155395368-155455839 [Contig_View]  NOX3 [Vega]
ICGC DataPortalENSG00000074771
TCGA cBioPortalNOX3
AceView (NCBI)NOX3
Genatlas (Paris)NOX3
SOURCE (Princeton)NOX3
Genetics Home Reference (NIH)NOX3
Genomic and cartography
GoldenPath hg38 (UCSC)NOX3  -     chr6:155395368-155455839 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOX3  -     6q25.3   [Description]    (hg19-Feb_2009)
GoldenPathNOX3 - 6q25.3 [CytoView hg19]  NOX3 - 6q25.3 [CytoView hg38]
ImmunoBaseENSG00000074771
Genome Data Viewer NCBINOX3 [Mapview hg19]  
OMIM607105   
Gene and transcription
Genbank (Entrez)AF190122 AF229177
RefSeq transcript (Entrez)NM_015718
Consensus coding sequences : CCDS (NCBI)NOX3
Gene ExpressionNOX3 [ NCBI-GEO ]   NOX3 [ EBI - ARRAY_EXPRESS ]   NOX3 [ SEEK ]   NOX3 [ MEM ]
Gene Expression Viewer (FireBrowse)NOX3 [ Firebrowse - Broad ]
GenevisibleExpression of NOX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50508
GTEX Portal (Tissue expression)NOX3
Human Protein AtlasENSG00000074771-NOX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBY0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBY0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBY0
Catalytic activity : Enzyme1.6.3.- [ Enzyme-Expasy ]   1.6.3.-1.6.3.- [ IntEnz-EBI ]   1.6.3.- [ BRENDA ]   1.6.3.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9HBY0
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)   
Domains : Interpro (EBI)Cyt_b245_heavy_chain    FAD-bd_8    FAD-bd_FR_type    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    FNR_nucleotide-bd    NOX3    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam08022    pfam01794    pfam08030   
Conserved Domain (NCBI)NOX3
SuperfamilyQ9HBY0
AlphaFold pdb e-kbQ9HBY0   
Human Protein Atlas [tissue]ENSG00000074771-NOX3 [tissue]
HPRD06165
Protein Interaction databases
DIP (DOE-UCLA)Q9HBY0
IntAct (EBI)Q9HBY0
BioGRIDNOX3
STRING (EMBL)NOX3
ZODIACNOX3
Ontologies - Pathways
QuickGOQ9HBY0
Ontology : AmiGOtemperature homeostasis  protein binding  cytoplasm  plasma membrane  plasma membrane  defense response  detection of gravity  superoxide-generating NAD(P)H oxidase activity  superoxide anion generation  NADPH oxidase complex  otolith development  extracellular exosome  
Ontology : EGO-EBItemperature homeostasis  protein binding  cytoplasm  plasma membrane  plasma membrane  defense response  detection of gravity  superoxide-generating NAD(P)H oxidase activity  superoxide anion generation  NADPH oxidase complex  otolith development  extracellular exosome  
Pathways : KEGGHIF-1 signaling pathway    Phagosome    Osteoclast differentiation    Leukocyte transendothelial migration   
NDEx NetworkNOX3
Atlas of Cancer Signalling NetworkNOX3
Wikipedia pathwaysNOX3
Orthology - Evolution
OrthoDB50508
GeneTree (enSembl)ENSG00000074771
Phylogenetic Trees/Animal Genes : TreeFamNOX3
Homologs : HomoloGeneNOX3
Homology/Alignments : Family Browser (UCSC)NOX3
Gene fusions - Rearrangements
Fusion : QuiverNOX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOX3
dbVarNOX3
ClinVarNOX3
MonarchNOX3
1000_GenomesNOX3 
Exome Variant ServerNOX3
GNOMAD BrowserENSG00000074771
Varsome BrowserNOX3
ACMGNOX3 variants
VarityQ9HBY0
Genomic Variants (DGV)NOX3 [DGVbeta]
DECIPHERNOX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOX3 
Mutations
ICGC Data PortalNOX3 
TCGA Data PortalNOX3 
Broad Tumor PortalNOX3
OASIS PortalNOX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOX3
Mutations and Diseases : HGMDNOX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNOX3
DgiDB (Drug Gene Interaction Database)NOX3
DoCM (Curated mutations)NOX3
CIViC (Clinical Interpretations of Variants in Cancer)NOX3
Cancer3DNOX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607105   
Orphanet
DisGeNETNOX3
MedgenNOX3
Genetic Testing Registry NOX3
NextProtQ9HBY0 [Medical]
GENETestsNOX3
Target ValidationNOX3
Huge Navigator NOX3 [HugePedia]
ClinGenNOX3
Clinical trials, drugs, therapy
MyCancerGenomeNOX3
Protein Interactions : CTDNOX3
Pharm GKB GenePA31691
PharosQ9HBY0
Clinical trialNOX3
Miscellaneous
canSAR (ICR)NOX3
HarmonizomeNOX3
DataMed IndexNOX3
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNOX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:05 CEST 2021

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