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NOX3 (NADPH oxidase 3)

Identity

Alias_symbol (synonym)GP91-3
Other aliasMOX-2
HGNC (Hugo) NOX3
LocusID (NCBI) 50508
Atlas_Id 49920
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 155395368 and ends at 155455903 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOX3   7890
Cards
Entrez_Gene (NCBI)NOX3  50508  NADPH oxidase 3
AliasesGP91-3; MOX-2
GeneCards (Weizmann)NOX3
Ensembl hg19 (Hinxton)ENSG00000074771 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074771 [Gene_View]  ENSG00000074771 [Sequence]  chr6:155395368-155455903 [Contig_View]  NOX3 [Vega]
ICGC DataPortalENSG00000074771
TCGA cBioPortalNOX3
AceView (NCBI)NOX3
Genatlas (Paris)NOX3
WikiGenes50508
SOURCE (Princeton)NOX3
Genetics Home Reference (NIH)NOX3
Genomic and cartography
GoldenPath hg38 (UCSC)NOX3  -     chr6:155395368-155455903 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOX3  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblNOX3 - 6q25.3 [CytoView hg19]  NOX3 - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBINOX3 [Mapview hg19]  NOX3 [Mapview hg38]
OMIM607105   
Gene and transcription
Genbank (Entrez)AF190122 AF229177
RefSeq transcript (Entrez)NM_015718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOX3
Cluster EST : UnigeneHs.247776 [ NCBI ]
CGAP (NCI)Hs.247776
Alternative Splicing GalleryENSG00000074771
Gene ExpressionNOX3 [ NCBI-GEO ]   NOX3 [ EBI - ARRAY_EXPRESS ]   NOX3 [ SEEK ]   NOX3 [ MEM ]
Gene Expression Viewer (FireBrowse)NOX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50508
GTEX Portal (Tissue expression)NOX3
Human Protein AtlasENSG00000074771-NOX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBY0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBY0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBY0
Splice isoforms : SwissVarQ9HBY0
Catalytic activity : Enzyme1.6.3.- [ Enzyme-Expasy ]   1.6.3.-1.6.3.- [ IntEnz-EBI ]   1.6.3.- [ BRENDA ]   1.6.3.- [ KEGG ]   
PhosPhoSitePlusQ9HBY0
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)   
Domains : Interpro (EBI)Cyt_b245_heavy_chain    FAD-bd_8    Fd_Rdtase_FAD-bd    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    NOX3    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam08022    pfam01794    pfam08030   
Conserved Domain (NCBI)NOX3
DMDM Disease mutations50508
Blocks (Seattle)NOX3
SuperfamilyQ9HBY0
Human Protein Atlas [tissue]ENSG00000074771-NOX3 [tissue]
Peptide AtlasQ9HBY0
HPRD06165
IPIIPI00024581   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBY0
IntAct (EBI)Q9HBY0
FunCoupENSG00000074771
BioGRIDNOX3
STRING (EMBL)NOX3
ZODIACNOX3
Ontologies - Pathways
QuickGOQ9HBY0
Ontology : AmiGOtemperature homeostasis  cytoplasm  plasma membrane  detection of gravity  superoxide-generating NADPH oxidase activity  superoxide anion generation  NADPH oxidase complex  otolith development  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBItemperature homeostasis  cytoplasm  plasma membrane  detection of gravity  superoxide-generating NADPH oxidase activity  superoxide anion generation  NADPH oxidase complex  otolith development  oxidation-reduction process  extracellular exosome  
Pathways : KEGGHIF-1 signaling pathway    Phagosome    Osteoclast differentiation    Leukocyte transendothelial migration   
NDEx NetworkNOX3
Atlas of Cancer Signalling NetworkNOX3
Wikipedia pathwaysNOX3
Orthology - Evolution
OrthoDB50508
GeneTree (enSembl)ENSG00000074771
Phylogenetic Trees/Animal Genes : TreeFamNOX3
HOVERGENQ9HBY0
HOGENOMQ9HBY0
Homologs : HomoloGeneNOX3
Homology/Alignments : Family Browser (UCSC)NOX3
Gene fusions - Rearrangements
Fusion : QuiverNOX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOX3
dbVarNOX3
ClinVarNOX3
1000_GenomesNOX3 
Exome Variant ServerNOX3
ExAC (Exome Aggregation Consortium)ENSG00000074771
GNOMAD BrowserENSG00000074771
Varsome BrowserNOX3
Genetic variants : HAPMAP50508
Genomic Variants (DGV)NOX3 [DGVbeta]
DECIPHERNOX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOX3 
Mutations
ICGC Data PortalNOX3 
TCGA Data PortalNOX3 
Broad Tumor PortalNOX3
OASIS PortalNOX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch NOX3
DgiDB (Drug Gene Interaction Database)NOX3
DoCM (Curated mutations)NOX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOX3 (select a term)
intoGenNOX3
Cancer3DNOX3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607105   
Orphanet
DisGeNETNOX3
MedgenNOX3
Genetic Testing Registry NOX3
NextProtQ9HBY0 [Medical]
TSGene50508
GENETestsNOX3
Target ValidationNOX3
Huge Navigator NOX3 [HugePedia]
snp3D : Map Gene to Disease50508
BioCentury BCIQNOX3
ClinGenNOX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50508
Chemical/Pharm GKB GenePA31691
Clinical trialNOX3
Miscellaneous
canSAR (ICR)NOX3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOX3
EVEXNOX3
GoPubMedNOX3
iHOPNOX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:26:40 CET 2018

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