Identity
HGNC
LOCATION
11q14.3
LOCUSID
ALIAS
KOX,KOX-1,RENOX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 50507
MIM: 605261
HGNC: 7891
Ensembl: ENSG00000086991
Variants:
dbSNP: 50507
ClinVar: 50507
TCGA: ENSG00000086991
COSMIC: NOX4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cellular responses to stress | REACTOME | R-HSA-2262752 |
| Detoxification of Reactive Oxygen Species | REACTOME | R-HSA-3299685 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37368156 | 2024 | DKK3 promotes oxidative stress injury and fibrosis in HK-2 cells by activating NOX4 via β-catenin/TCF4 signaling. | 0 |
| 37989920 | 2024 | NADPH oxidase 4-mediating oxidative stress contributes to endometriosis. | 0 |
| 38092301 | 2024 | NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis. | 0 |
| 38340945 | 2024 | CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1. | 0 |
| 38348042 | 2024 | Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis. | 0 |
| 38379095 | 2024 | Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans. | 0 |
| 38387281 | 2024 | Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis. | 0 |
| 38593505 | 2024 | NOX4 regulates gastric cancer cell invasion and proliferation by increasing ferroptosis sensitivity through regulating ROS. | 0 |
| 38663913 | 2024 | Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration. | 0 |
| 38690939 | 2024 | NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration. | 0 |
| 37368156 | 2024 | DKK3 promotes oxidative stress injury and fibrosis in HK-2 cells by activating NOX4 via β-catenin/TCF4 signaling. | 0 |
| 37989920 | 2024 | NADPH oxidase 4-mediating oxidative stress contributes to endometriosis. | 0 |
| 38092301 | 2024 | NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis. | 0 |
| 38340945 | 2024 | CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1. | 0 |
| 38348042 | 2024 | Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis. | 0 |
Citation
Dessen P
NOX4 (NADPH oxidase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41562/nox4
