Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NOX4 (NADPH oxidase 4)

Identity

Alias (NCBI)KOX
KOX-1
RENOX
HGNC (Hugo) NOX4
HGNC Alias symbKOX-1
KOX
LocusID (NCBI) 50507
Atlas_Id 41562
Location 11q14.3  [Link to chromosome band 11q14]
Location_base_pair Starts at 89324354 and ends at 89491375 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRP5 (11q13.2) / NOX4 (11q14.3)NFRKB (11q24.3) / NOX4 (11q14.3)ZFP91 (11q12.1) / NOX4 (11q14.3)
LRP5 11q13.2 / NOX4 11q14.3NFRKB 11q24.3 / NOX4 11q14.3ZFP91 11q12.1 / NOX4 11q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;11)(q12;q14) ZFP91/NOX4
t(11;11)(q13;q14) LRP5/NOX4
t(11;11)(q14;q24) NFRKB/NOX4

External links

Nomenclature
HGNC (Hugo)NOX4   7891
Cards
Entrez_Gene (NCBI)NOX4    NADPH oxidase 4
AliasesKOX; KOX-1; RENOX
GeneCards (Weizmann)NOX4
Ensembl hg19 (Hinxton)ENSG00000086991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086991 [Gene_View]  ENSG00000086991 [Sequence]  chr11:89324354-89491375 [Contig_View]  NOX4 [Vega]
ICGC DataPortalENSG00000086991
TCGA cBioPortalNOX4
AceView (NCBI)NOX4
Genatlas (Paris)NOX4
SOURCE (Princeton)NOX4
Genetics Home Reference (NIH)NOX4
Genomic and cartography
GoldenPath hg38 (UCSC)NOX4  -     chr11:89324354-89491375 -  11q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOX4  -     11q14.3   [Description]    (hg19-Feb_2009)
GoldenPathNOX4 - 11q14.3 [CytoView hg19]  NOX4 - 11q14.3 [CytoView hg38]
ImmunoBaseENSG00000086991
genome Data Viewer NCBINOX4 [Mapview hg19]  
OMIM605261   
Gene and transcription
Genbank (Entrez)AB041035 AF254621 AF261943 AJ704725 AJ704726
RefSeq transcript (Entrez)NM_001143836 NM_001143837 NM_001291926 NM_001291927 NM_001291929 NM_001300995 NM_016931
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOX4
Alternative Splicing GalleryENSG00000086991
Gene ExpressionNOX4 [ NCBI-GEO ]   NOX4 [ EBI - ARRAY_EXPRESS ]   NOX4 [ SEEK ]   NOX4 [ MEM ]
Gene Expression Viewer (FireBrowse)NOX4 [ Firebrowse - Broad ]
GenevisibleExpression of NOX4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50507
GTEX Portal (Tissue expression)NOX4
Human Protein AtlasENSG00000086991-NOX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPH5
Splice isoforms : SwissVarQ9NPH5
Catalytic activity : Enzyme1.6.3.- [ Enzyme-Expasy ]   1.6.3.-1.6.3.- [ IntEnz-EBI ]   1.6.3.- [ BRENDA ]   1.6.3.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NPH5
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)   
Domains : Interpro (EBI)Cyt_b245_heavy_chain    FAD-bd_8    FAD-bd_FR_type    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    FNR_nucleotide-bd    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam08022    pfam01794    pfam08030   
Conserved Domain (NCBI)NOX4
Blocks (Seattle)NOX4
SuperfamilyQ9NPH5
Human Protein Atlas [tissue]ENSG00000086991-NOX4 [tissue]
Peptide AtlasQ9NPH5
HPRD09243
IPIIPI01016002   IPI00552918   IPI00553065   IPI00759558   IPI00385546   IPI00759550   IPI00759781   IPI00976646   IPI00977032   IPI00979439   IPI00922686   IPI00978411   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPH5
IntAct (EBI)Q9NPH5
BioGRIDNOX4
STRING (EMBL)NOX4
ZODIACNOX4
Ontologies - Pathways
QuickGOQ9NPH5
Ontology : AmiGOnucleotide binding  cell morphogenesis  response to hypoxia  stress fiber  heart process  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  endoplasmic reticulum membrane  plasma membrane  focal adhesion  superoxide metabolic process  defense response  inflammatory response  cell aging  negative regulation of cell proliferation  electron transfer activity  gene expression  positive regulation of smooth muscle cell migration  integral component of membrane  NAD(P)H oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  oxygen sensor activity  heme binding  electron transport chain  cellular response to oxidative stress  superoxide anion generation  superoxide anion generation  NADPH oxidase complex  positive regulation of apoptotic process  positive regulation of MAP kinase activity  bone resorption  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  homocysteine metabolic process  positive regulation of stress fiber assembly  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  oxidation-reduction process  oxidation-reduction process  positive regulation of protein tyrosine kinase activity  positive regulation of ERK1 and ERK2 cascade  cellular response to cAMP  cellular response to glucose stimulus  cellular response to gamma radiation  cellular response to transforming growth factor beta stimulus  modified amino acid binding  reactive oxygen species metabolic process  perinuclear endoplasmic reticulum  reactive oxygen species biosynthetic process  protein tyrosine kinase binding  positive regulation of reactive oxygen species metabolic process  positive regulation of DNA biosynthetic process  
Ontology : EGO-EBInucleotide binding  cell morphogenesis  response to hypoxia  stress fiber  heart process  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  endoplasmic reticulum membrane  plasma membrane  focal adhesion  superoxide metabolic process  defense response  inflammatory response  cell aging  negative regulation of cell proliferation  electron transfer activity  gene expression  positive regulation of smooth muscle cell migration  integral component of membrane  NAD(P)H oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  oxygen sensor activity  heme binding  electron transport chain  cellular response to oxidative stress  superoxide anion generation  superoxide anion generation  NADPH oxidase complex  positive regulation of apoptotic process  positive regulation of MAP kinase activity  bone resorption  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  homocysteine metabolic process  positive regulation of stress fiber assembly  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  oxidation-reduction process  oxidation-reduction process  positive regulation of protein tyrosine kinase activity  positive regulation of ERK1 and ERK2 cascade  cellular response to cAMP  cellular response to glucose stimulus  cellular response to gamma radiation  cellular response to transforming growth factor beta stimulus  modified amino acid binding  reactive oxygen species metabolic process  perinuclear endoplasmic reticulum  reactive oxygen species biosynthetic process  protein tyrosine kinase binding  positive regulation of reactive oxygen species metabolic process  positive regulation of DNA biosynthetic process  
NDEx NetworkNOX4
Atlas of Cancer Signalling NetworkNOX4
Wikipedia pathwaysNOX4
Orthology - Evolution
OrthoDB50507
GeneTree (enSembl)ENSG00000086991
Phylogenetic Trees/Animal Genes : TreeFamNOX4
HOGENOMQ9NPH5
Homologs : HomoloGeneNOX4
Homology/Alignments : Family Browser (UCSC)NOX4
Gene fusions - Rearrangements
Fusion : MitelmanLRP5/NOX4 [11q13.2/11q14.3]  
Fusion : MitelmanNFRKB/NOX4 [11q24.3/11q14.3]  
Fusion : MitelmanZFP91/NOX4 [11q12.1/11q14.3]  
Fusion PortalLRP5 11q13.2 NOX4 11q14.3 BRCA
Fusion PortalNFRKB 11q24.3 NOX4 11q14.3 BRCA
Fusion PortalZFP91 11q12.1 NOX4 11q14.3 BRCA
Fusion : QuiverNOX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOX4 [hg38]
dbVarNOX4
ClinVarNOX4
MonarchNOX4
1000_GenomesNOX4 
Exome Variant ServerNOX4
GNOMAD BrowserENSG00000086991
Varsome BrowserNOX4
Genomic Variants (DGV)NOX4 [DGVbeta]
DECIPHERNOX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOX4 
Mutations
ICGC Data PortalNOX4 
TCGA Data PortalNOX4 
Broad Tumor PortalNOX4
OASIS PortalNOX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOX4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOX4
Mutations and Diseases : HGMDNOX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NOX4
DgiDB (Drug Gene Interaction Database)NOX4
DoCM (Curated mutations)NOX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOX4 (select a term)
intoGenNOX4
Cancer3DNOX4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605261   
Orphanet
DisGeNETNOX4
MedgenNOX4
Genetic Testing Registry NOX4
NextProtQ9NPH5 [Medical]
GENETestsNOX4
Target ValidationNOX4
Huge Navigator NOX4 [HugePedia]
ClinGenNOX4
Clinical trials, drugs, therapy
MyCancerGenomeNOX4
Protein Interactions : CTD
Pharm GKB GenePA31692
PharosQ9NPH5
Clinical trialNOX4
Miscellaneous
canSAR (ICR)NOX4 (select the gene name)
HarmonizomeNOX4
DataMed IndexNOX4
Probes
Litterature
PubMed316 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNOX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:29:14 CET 2021
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