NOX4 (NADPH oxidase 4)

2003-05-01 Affiliation

Identity

HGNC

NOX4

LOCATION

11q14.3

LOCUSID

50507

ALIAS

KOX,KOX-1,RENOX

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50507
MIM: 605261
HGNC: 7891
Ensembl: ENSG00000086991

Variants:

dbSNP: 50507
ClinVar: 50507
TCGA: ENSG00000086991
COSMIC: NOX4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000086991	ENST00000263317	Q9NPH5
ENSG00000086991	ENST00000343727	Q9NPH5
ENSG00000086991	ENST00000375979	Q9NPH5
ENSG00000086991	ENST00000393282	Q9NPH5
ENSG00000086991	ENST00000424319	Q9NPH5
ENSG00000086991	ENST00000525196	E9PI95
ENSG00000086991	ENST00000527626	E9PR43
ENSG00000086991	ENST00000527956	Q9NPH5
ENSG00000086991	ENST00000528341	E9PPP2
ENSG00000086991	ENST00000529343	Q9NPH5
ENSG00000086991	ENST00000531342	Q9NPH5
ENSG00000086991	ENST00000532825	Q9NPH5
ENSG00000086991	ENST00000534731	Q9NPH5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685

References

Pubmed ID	Year	Title	Citations
19701206	2009	NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.	301
15927447	2006	Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.	290
17501721	2007	NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.	248
14670934	2004	Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.	220
22456182	2012	Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.	205
24718857	2014	Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance.	195
15356101	2004	Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.	193
18573911	2008	Regulation of ROS signal transduction by NADPH oxidase 4 localization.	190
19574552	2009	Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.	190
15322091	2004	Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.	181

Citation

Dessen P

NOX4 (NADPH oxidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41562/nox4