NOX5 (NADPH oxidase 5)

2008-03-01 Affiliation

Identity

HGNC

NOX5

LOCATION

15q23

LOCUSID

79400

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79400
MIM: 606572
HGNC: 14874
Ensembl: ENSG00000255346

Variants:

dbSNP: 79400
ClinVar: 79400
TCGA: ENSG00000255346
COSMIC: NOX5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000255346	ENST00000260364	Q96PH1
ENSG00000255346	ENST00000388866	Q96PH1
ENSG00000255346	ENST00000448182	Q96PH1
ENSG00000255346	ENST00000455873	Q96PH1
ENSG00000255346	ENST00000525143	A0A0B4J289
ENSG00000255346	ENST00000530406	Q96PH1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685

References

Pubmed ID	Year	Title	Citations
11483596	2001	A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes.	154
14982937	2004	Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).	106
17164239	2007	Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation.	81
18466778	2008	Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells.	63
16707484	2006	cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.	56
20339118	2010	Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.	54
17587483	2007	NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation.	53
22182486	2012	NOX5: from basic biology to signaling and disease.	50
22291013	2012	NOX5 in human spermatozoa: expression, function, and regulation.	39
16339585	2005	Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia.	37

Citation

Dessen P

NOX5 (NADPH oxidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50047/nox5